chamigrene

isochamigrene is a side product of trichodiene synthase, a key enzyme in the biosynthesis of trichothecene mycotoxins from Fusarium spp.

Also Known As:

(S)-isochamigrene; isochamigrene; (6R)-5,5,9-trimethyl-1-methylidenespiro(5.5)undec-9-ene

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

1.	Neoplasms (Cancer) 04/01/2018 - "Evaluation of in vitro cytotoxicity against several cancer and non-tumourigenic cells indicated promising activity, especially to HeLa (human cervical carcinoma) with IC50 ranging from 11 ± 3 to 17 ± 3 μg/mL. The obtained volatile oils were pooled and subjected to fractionation to afford pure β-caryophyllene, α-chamigrene and germacrene D, being this last compound the more active against HeLa cells with IC50 of 7 ± 1 μg/mL (34 ± 5 μM). "
2.	Carcinoma (Carcinomatosis) 04/01/2018 - "Evaluation of in vitro cytotoxicity against several cancer and non-tumourigenic cells indicated promising activity, especially to HeLa (human cervical carcinoma) with IC50 ranging from 11 ± 3 to 17 ± 3 μg/mL. The obtained volatile oils were pooled and subjected to fractionation to afford pure β-caryophyllene, α-chamigrene and germacrene D, being this last compound the more active against HeLa cells with IC50 of 7 ± 1 μg/mL (34 ± 5 μM). "

1.	Volatile Oils (Essential Oils)
2.	germacrene D
3.	caryophyllene