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NMS-873

an inhibitor of VCP, a ubiquitin-dependent segregase, with antiviral activity

Networked: 6 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chou, Tsui-Fen: 2 articles (03/2022 - 03/2021)
2.	Li, Shan: 2 articles (03/2022 - 03/2021)
3.	Wang, Feng: 2 articles (03/2022 - 03/2021)
4.	Zhang, Gang: 2 articles (03/2022 - 03/2021)
5.	Deshaies, Raymond J: 1 article (03/2021)
6.	Goldberg, Alexander F G: 1 article (03/2021)
7.	Jones, Amanda C: 1 article (03/2021)
8.	Lin, Benjamin: 1 article (03/2021)
9.	Stoltz, Brian M: 1 article (03/2021)
10.	Virgil, Scott: 1 article (03/2021)

Related Diseases

1.	Infections 05/01/2017 - "Finally, we show that NMS-873, a small molecule inhibitor of VCP, is a potent HCMV antiviral with potential as a novel host targeting therapeutic for HCMV infection."
2.	Human Influenza (Influenza) 05/15/2019 - "In this study, we discovered NMS-873, an allosteric and specific p97 inhibitor, as a broad-spectrum influenza antiviral through forward chemical genomics screening. " 05/15/2019 - "Identification of NMS-873, an allosteric and specific p97 inhibitor, as a broad antiviral against both influenza A and B viruses." 05/15/2019 - "NMS-873 shows potent antiviral activity with low-nanomolar EC50s against multiple human influenza A and B viruses, including adamantine-, oseltamivir-, or double resistant strains. "
3.	Neoplasms (Cancer) 09/01/2013 - "Chemical expansion of this allosteric class identified NMS-873, the most potent and specific VCP inhibitor described to date, which activated the unfolded protein response, interfered with autophagy and induced cancer cell death. " 03/31/2022 - "The polypharmacology of NMS-873 can be advantageous for anti-cancer therapy for colon cancer."
4.	Colorectal Neoplasms (Colorectal Cancer) 03/05/2021 - "A covalent p97/VCP ATPase inhibitor can overcome resistance to CB-5083 and NMS-873 in colorectal cancer cells."
5.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/01/2020 - "Interestingly, NMS-873 was able to reduce disease severity in CD4+ T cell-driven experimental autoimmune encephalomyelitis (EAE). "

Related Drugs and Biologics

1.	Antiviral Agents (Antivirals)
2.	Oseltamivir (Tamiflu)
3.	Adenosine Triphosphatases (ATPase)
4.	CB-5083

Related Therapies and Procedures

1.	Therapeutics