GPR39-C3

a GPR39 agonist with antidepressant activity; structure in first source

Also Known As:

N-(3-chloro-4-(((2-(methylamino)-6-(2-pyridinyl)-4-pyrimidinyl)amino)methyl)phenyl)methanesulfonamide; TC-G 1008

Networked: 10 relevant articles (3 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - GPR39-C3: 10
Organic Chemicals: 133
- Amides: 2428
  - Sulfonamides: 2809
    - GPR39-C3: 10
- Sulfur Compounds: 278
  - Sulfones: 534
    - Sulfonamides: 2809
      - GPR39-C3: 10

Experts

1.	Goto, Megumi: 2 articles (08/2019 - 09/2018)
2.	Kadoshima-Yamaoka, Kumiko: 2 articles (08/2019 - 09/2018)
3.	Muneoka, Satoshi: 2 articles (08/2019 - 09/2018)
4.	Tomimori, Yoshiaki: 2 articles (08/2019 - 09/2018)
5.	Doycheva, Desislava Met: 1 article (10/2021)
6.	Gao, Ling: 1 article (10/2021)
7.	Hu, Xiao: 1 article (10/2021)
8.	Jiang, Xili: 1 article (10/2021)
9.	Jin, Peng: 1 article (10/2021)
10.	Liu, Rui: 1 article (10/2021)

Related Diseases

1.	Neuroinflammatory Diseases 10/16/2023 - "Collectively, TC-G 1008 markedly alleviated NP and neuroinflammation in CCI-treated rats. " 10/13/2021 - "TC-G 1008 attenuated neuroinflammation in part via the SIRT1/PGC-1α/Nrf2 pathway in a neonatal rat model of HIE. " 03/01/2024 - "Intrathecal injection of TC-G 1008, a specific agonist of GPR39, significantly alleviated mechanical allodynia in the rats with spared nerve injury, improved spinal cord mitochondrial biogenesis, and alleviated neuroinflammation. " 10/16/2023 - "G protein-coupled receptor 39 (GPR39) is a trans-membrane protein involved in the activation of cellular transduction pathways, and TC-G 1008, a GPR39 agonist, is believed to have inhibitory effects on neuroinflammation. "
2.	Sepsis (Septicemia) 09/05/2018 - "Moreover, the oral administration of TC-G 1008 significantly improved the survival rate in the LPS-induced murine model of sepsis. " 09/05/2018 - "In addition, the oral administration of TC-G 1008 enhanced serum IL-10 concentrations in an LPS-induced murine model of sepsis. " 09/05/2018 - "The ablation of G protein-coupled receptor 39 significantly reduced IL-10 production by TC-G 1008 in thioglycollate-induced peritoneal macrophages stimulated with LPS and in the LPS-induced murine model of sepsis. "
3.	Inflammation (Inflammations) 12/15/2019 - "The protective effects of the GPR39 agonist TC-G 1008 against TNF-α-induced inflammation in human fibroblast-like synoviocytes (FLSs)."
4.	Hyperalgesia 03/01/2024 - "Intrathecal injection of TC-G 1008, a specific agonist of GPR39, significantly alleviated mechanical allodynia in the rats with spared nerve injury, improved spinal cord mitochondrial biogenesis, and alleviated neuroinflammation. "
5.	Neurodegenerative Diseases (Neurodegenerative Disease) 12/15/2023 - "Since a role for zinc has been postulated in neurodegenerative disorders, in this study we investigated the possibility of a pharmacological rescue of both types of declarative memory with memantine - a noncompetitive NMDAR antagonist used for slowing down dementia; or, a putative GPR39 agonist - TC-G 1008. "

Related Drugs and Biologics

1.	Zinc
2.	Memantine (Namenda)
3.	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)
4.	Sirtuin 1
5.	Matrix Metalloproteinases (MMPs)
6.	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)
7.	Interleukin-10 (Interleukin 10)
8.	Cytokines
9.	Interleukin-6 (Interleukin 6)
10.	Pentylenetetrazole (Metrazol)

Related Therapies and Procedures

1.	Oral Administration
2.	Spinal Injections