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BI 1002494

a spleen tyrosine kinase inhibitor; structure in first source

Also Known As:

4-(1-(7-(3,4,5-trimethoxyphenyl)-(1,6)napthyridin-5-yloxy)ethyl)pyrrolidin-2-one

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 207
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 121
    - Pyrrolidinones: 169
      - BI 1002494: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Naphthyridines: 2
      - BI 1002494: 1

Experts

1.	Christ, Ingrid: 1 article (04/2020)
2.	Colbatzky, Florian: 1 article (04/2020)
3.	Glüxam, Tobias: 1 article (04/2020)
4.	Harrer, Nathalie: 1 article (04/2020)
5.	Lamb, David J: 1 article (04/2020)
6.	Machat, Herwig: 1 article (04/2020)
7.	Osswald, Annika: 1 article (04/2020)
8.	Rudisch, Albin: 1 article (04/2020)
9.	Rust, Aleksander: 1 article (04/2020)
10.	Sommergruber, Wolfgang: 1 article (04/2020)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 04/07/2020 - "The SYK inhibitor, BI 1002494, caused no increase in proliferation in breast cancer cells or primary mammary epithelial cells in 2D or 3D cultures, nor changes in proliferation (CD1/2, CDK4, PCNA, Ki67) or invadopodia markers (MMP14, PARP, phospho-vimentin Ser56). "

Related Drugs and Biologics

1.	Proliferating Cell Nuclear Antigen (PCNA)
2.	Vimentin