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G-1 ethanone compound

a G-protein estrogen receptor (GPER) agonist

Also Known As:

1-(4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone; GPR30 agonist G1

Networked: 15 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - G-1 ethanone compound: 15

Experts

1.	Wang, Ruimin: 3 articles (01/2021 - 04/2014)
2.	Brann, Darrell W: 2 articles (05/2014 - 04/2014)
3.	Dong, Yan: 2 articles (05/2014 - 04/2014)
4.	Khan, Mohammad: 2 articles (05/2014 - 04/2014)
5.	Tang, Hui: 2 articles (05/2014 - 04/2014)
6.	Yang, Fang: 2 articles (05/2014 - 04/2014)
7.	Yang, Licai: 2 articles (05/2014 - 04/2014)
8.	Zhang, Quanguang: 2 articles (05/2014 - 04/2014)
9.	Li, Xiao-qiang: 2 articles (04/2012 - 01/2012)
10.	Liu, Shui-bing: 2 articles (04/2012 - 01/2012)

Related Diseases

1.	Brain Ischemia (Cerebral Ischemia) 05/25/2014 - "Studies using exogenous administration of the GPR30 agonist, G1 suggests that GPR30 may have a neuroprotective role in cerebral ischemia. " 04/25/2014 - "Studies using exogenous administration of the GPR30 agonist, G1 suggests that GPR30 may have a neuroprotective role in cerebral ischemia. " 10/01/2019 - "Previous studies showed that the activation of G protein-coupled receptor 30 (GPR30) with GPR30 agonist G1 was anti-apoptotic after experimental trauma brain injury and global cerebral ischemia in male rats or mice. " 01/01/2021 - "Our previous study revealed that G-protein-coupled estrogen receptor-30 (GPR30) agonist G1 serves as a viable alternative neuroprotectant of 17β-estradiol (E2) to attenuate neuroinflammation and improve cognitive function after global cerebral ischemia (GCI). "
2.	Traumatic Brain Injuries (Traumatic Brain Injury) 08/01/2018 - "Effects of estrogen receptor GPR30 agonist G1 on neuronal apoptosis and microglia polarization in traumatic brain injury rats." 10/01/2019 - "Previous studies showed that the activation of G protein-coupled receptor 30 (GPR30) with GPR30 agonist G1 was anti-apoptotic after experimental trauma brain injury and global cerebral ischemia in male rats or mice. " 08/01/2018 - "To investigate the effects of estrogen G protein-coupled receptor 30 (GPR30) agonist G1 on hippocampal neuronal apoptosis and microglial polarization in rat traumatic brain injury (TBI). "
3.	Cognitive Dysfunction 10/01/2023 - "GPR30 agonist G1 combined with HT reduces cognitive impairment and anxiety-like behavior in rats with SAH." 10/01/2023 - "GPR30 agonist G1 combined with hypothermia alleviates cognitive impairment and anxiety-like behavior after subarachnoid hemorrhage in rats." 10/01/2023 - "This study aimed to investigate the treatment effect of G protein-coupled receptor 30 (GPR30) agonist G1 combined with hypothermia (HT) on cognitive impairment and anxiety-like behavior after subarachnoid hemorrhage (SAH) in rats. "
4.	Reperfusion Injury 01/01/2021 - "The current study aims to explore whether GPR30 agonist (G1) can alleviate hepatic ischemia-reperfusion injury HI/R by inhibiting NLRP3. "
5.	Wounds and Injuries (Trauma) 11/01/2016 - "Moreover, our in vitro study showed that both the selective GPR30 agonist G1 and the general ER agonist 17-β-estradiol were able to protect the placenta from hypoxia-reoxygenation injuries, resulting in decreased apoptosis and increased proliferation. "

Related Drugs and Biologics

1.	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)
2.	Estrogens (Estrogen)
3.	GTP-Binding Proteins (G-Protein)
4.	Neuroprotective Agents
5.	Brain Natriuretic Peptide (Natrecor)
6.	Myosin Heavy Chains (Myosin Heavy Chain)
7.	Estrogen Receptors
8.	Atrial Natriuretic Factor (ANF)
9.	Diethylstilbestrol (Stilbestrol)
10.	Dehydroepiandrosterone (DHEA)

Related Therapies and Procedures

1.	Spinal Injections