Helium-3

08/01/2013 - "We enrolled 38 ex-smokers and 15 subjects with stage I COPD who underwent spirometry, plethysmography, St George's Respiratory Questionnaire (SGRQ), 6 min Walk Test (6MWT), x-ray CT and hyperpolarised helium-3 ((3)He) MRI. "
05/01/2013 - "A chronic obstructive pulmonary disease (COPD) exsmoker underwent pulmonary function tests and hyperpolarized helium-3 ((3) He) magnetic resonance imaging (MRI) serially over 4 years, twice prior to and twice following an acute exacerbation (AE). "
05/01/2013 - "Hyperpolarized helium-3 magnetic resonance imaging of chronic obstructive pulmonary disease exacerbation."
07/01/2011 - "The aim of this pilot study in a small group of chronic obstructive pulmonary disease (COPD) patients was to quantify hyperpolarized helium-3 ((3)He) magnetic resonance imaging (MRI) functional and structural measurements and to explore the potential role for (3)He MRI in detecting the lung structural and functional COPD phenotypes. "
12/01/2007 - "To evaluate the anatomical distribution of apparent diffusion coefficients (ADC) using hyperpolarized helium-3 (3He) MRI in chronic obstructive pulmonary disease (COPD). "

01/01/2010 - "This technique represents the first demonstration of a spatially resolved hyperpolarized helium-3 q-space imaging technique and shows promise for microstructural evaluation of lung disease in three dimensions."
06/01/2003 - "Applications of hyperpolarized helium-3 gas magnetic resonance imaging in pediatric lung disease."
06/01/2003 - "Hyperpolarized helium-3 (HHe3) provides a new technique for magnetic resonance imaging of lung diseases. "
11/01/1996 - "To assess the feasibility of helium-3 magnetic resonance (MR) imaging with a three-dimensional fast low-angle shot (FLASH) sequence, He-3 gas (volume, 300 mL; pressure, 3 x 10(5) Pa; polarized up to 45% by means of optimal pumping) was inhaled by five healthy volunteers and five patients with pulmonary diseases. "
11/01/2018 - "Hyperpolarised helium-3 (3He) ventilation magnetic resonance imaging (MRI) and multiple-breath washout (MBW) are sensitive methods for detecting lung disease in cystic fibrosis (CF). "

10/01/2006 - "Hyperpolarized helium-3 MRI (H(3)HeMR) is a new technique in which the airspaces are visualized, depicting regions with airflow obstruction as "ventilation defects." The objective of this study was to compare the extent of H(3)HeMR ventilation defects with measures of asthma severity and spirometry. "
01/01/2021 - "Measures of ventilation heterogeneity mapped with hyperpolarized helium-3 MRI demonstrate a T2-high phenotype in asthma."
10/01/2020 - "Ventilation defects on hyperpolarized helium-3 MRI in asthma are predictive of 2-year exacerbation frequency."
01/01/2018 - "Regional Heterogeneity of Lobar Ventilation in Asthma Using Hyperpolarized Helium-3 MRI."
12/01/2010 - "Demonstration of the heterogeneous distribution of asthma in the lungs using CT and hyperpolarized helium-3 MRI."

09/01/2006 - "This study investigated the role of changes in calcium levels in bystander responses leading to chromosomal damage in nonirradiated T98G glioma cells and AG01522 fibroblasts that had been either exposed to conditioned medium from irradiated cells or co-cultured with a population where a fraction of cells were individually targeted through the nucleus or cytoplasm with a precise number of microbeam helium-3 particles. "

12/01/2014 - "We assessed repeatability of lung function measurement using HP helium-3 MRI (HP (3)He MRI) in a small cohort of patients with cystic fibrosis (CF). "
08/01/2011 - "To better understand imaging measurement precision and reproducibility and to provide guidance for measurements in individual cystic fibrosis (CF) subjects, we evaluated CF adults on two occasions 7 ± 2 days apart using spirometry, plethysmography, and hyperpolarized helium-3 ((3)He) magnetic resonance imaging (MRI). "
08/01/2011 - "Quantitative evaluation of hyperpolarized helium-3 magnetic resonance imaging of lung function variability in cystic fibrosis."
11/01/2018 - "Hyperpolarised helium-3 (3He) ventilation magnetic resonance imaging (MRI) and multiple-breath washout (MBW) are sensitive methods for detecting lung disease in cystic fibrosis (CF). "
03/01/2017 - "Use of hyperpolarized helium-3 MRI to assess response to ivacaftor treatment in patients with cystic fibrosis."