Normal and abnormal pulmonary ventilation: visualization at hyperpolarized He-3 MR imaging.

Abstract

To assess the feasibility of helium-3 magnetic resonance (MR) imaging with a three-dimensional fast low-angle shot (FLASH) sequence, He-3 gas (volume, 300 mL; pressure, 3 x 10(5) Pa; polarized up to 45% by means of optimal pumping) was inhaled by five healthy volunteers and five patients with pulmonary diseases. All breath-hold examinations (22-42 seconds) were completed successfully. Normal ventilation was depicted with homogeneous high signal intensity, lesions were depicted as causing defects, and obstructive lung disease was depicted with severely inhomogeneous signal intensity.

• Authors: H U Kauczor, D Hofmann, K F Kreitner, H Nilgens, R Surkau, W Heil, A Potthast, M V Knopp, E W Otten, M Thelen
• Journal: Radiology (Radiology) Vol. 201 Issue 2 Pg. 564-8 (Nov 1996) ISSN: 0033-8419 [Print] United States
• PMID: 8888259 (Publication Type: Journal Article)

Chemical References

• Isotopes
• Helium

Topics

• Administration, Inhalation
• Adult
• Bronchi (anatomy & histology, pathology)
• Helium
• Humans
• Isotopes
• Lung (anatomy & histology, pathology, physiology)
• Lung Diseases (diagnosis, physiopathology)
• Magnetic Resonance Imaging (methods)
• Middle Aged
• Respiration
• Trachea (anatomy & histology, pathology)