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3'-oxomethylisoeugenol

a topoisomerase I inhibitor; a metabolite of methyleugenol; structure in first source

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Esselen, Melanie: 2 articles (10/2017 - 11/2016)
2.	Groh, Isabel Anna Maria: 2 articles (10/2017 - 11/2016)
3.	Gründken, Malte: 1 article (11/2016)
4.	Marko, Doris: 1 article (11/2016)
5.	Rudakovski, Olga: 1 article (11/2016)
6.	Schroeter, Anika: 1 article (11/2016)

Related Diseases

1.	Carcinoma (Carcinomatosis) 10/01/2017 - "In this study, the question addressed was whether methyleugenol and the selected oxidative metabolites, 1'-hydroxymethyleugenol, methyleugenol-2',3'-epoxide and 3'-oxomethylisoeugenol trigger a DNA damage response in the human colon carcinoma HT29 cell line. "
2.	Poisoning 11/01/2016 - "In conclusion, it could be suggested that 3'-oxomethylisoeugenol may also interact with classical or food-borne topoisomerase I poisons, diminishing their poisoning effectiveness." 11/01/2016 - "Methyleugenol-2',3'-epoxide and 3'-oxomethylisoeugenol inhibited the activity of recombinant topoisomerase I. In HT29 cells, neither methyleugenol nor the metabolites affected the level of topoisomerase protein bound to DNA, excluding a topoisomerase poisoning mode of action. "

Related Drugs and Biologics

1.	methyleugenol (methyl eugenol)
2.	methyleugenol-2',3'-epoxide
3.	A-Form DNA (A-DNA)
4.	1'-(hydroxymethyl)eugenol
5.	Proteins (Proteins, Gene)
6.	Poisons
7.	Type I DNA Topoisomerases (Topoisomerase I)
8.	DNA (Deoxyribonucleic Acid)