Valosin Containing Protein

A highly-conserved AAA ATPase that functions in the biogenesis of the transitional ENDOPLASMIC RETICULUM and fragmentation and reassembly of the GOLGI APPARATUS during MITOSIS. It also functions in a complex with UFD1L and NPLOC4 proteins to export misfolded ubiquitinated proteins from the endoplasmic reticulum and outer mitochondrial membrane to the cytoplasm for degradation by the PROTEASOME and also plays a role in AUTOPHAGY of ubiquitinated proteins. It occurs in neuronal INCLUSION BODIES from patients with AMYOTROPHIC LATERAL SCLEROSIS and LEWY BODIES from PARKINSON DISEASE patients.

Also Known As:

CDC48 Protein; Cell Cycle Protein CDC48; Cell Cycle Protein CDC48p; Valosin-Containing Protein; Valosine-Containing Protein; p97 Valosin-Containing Protein; Valosin-Containing Protein, p97; Valosine Containing Protein; p97 Valosin Containing Protein

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Acid Anhydride Hydrolases
      - Adenosine Triphosphatases: 8623
        ATPases Associated with Diverse Cellular Activities: 163
        Valosin Containing Protein: 318
      - AAA Proteins: 25
        ATPases Associated with Diverse Cellular Activities: 163
        Valosin Containing Protein: 318
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - AAA Proteins: 25
      - ATPases Associated with Diverse Cellular Activities: 163
        Valosin Containing Protein: 318
  - Cell Cycle Proteins: 807
    - Valosin Containing Protein: 318

S cerevisiae CDC48 protein

Bio-Agent Context: Research Results