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5A peptide

a synthetic apolipoprotein mimetic with atheroprotective activity; also a CD36 scavenger receptor antagonist

Networked: 4 relevant articles (2 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intercellular Signaling Peptides and Proteins: 29768
    - 5A peptide: 4
- Peptides: 82426
  - Intercellular Signaling Peptides and Proteins: 29768
    - 5A peptide: 4
Biological Factors: 2472
- Intercellular Signaling Peptides and Proteins: 29768
  - 5A peptide: 4

Experts

1.	Remaley, Alan T: 3 articles (01/2016 - 02/2010)
2.	Yanagita, Motoko: 1 article (04/2016)
3.	Yokoi, Hideki: 1 article (04/2016)
4.	Becker, Felix: 1 article (01/2016)
5.	Bettenworth, Dominik: 1 article (01/2016)
6.	Eisenblätter, Michel: 1 article (01/2016)
7.	Heidemann, Jan: 1 article (01/2016)
8.	Lügering, Andreas: 1 article (01/2016)
9.	Nofer, Jerzy-Roch: 1 article (01/2016)
10.	Nowacki, Tobias M: 1 article (01/2016)

Related Diseases

1.	Inflammation (Inflammations) 02/01/2010 - "We investigated whether the 5A peptide shares other beneficial features of apoA-I, such as protection against inflammation and oxidation. " 02/01/2010 - "Like apoA-I, the 5A peptide inhibits acute inflammation and oxidative stress in rabbit carotids and HCAECs. " 01/01/2016 - "Daily treatment with 5A peptide potently restricted DSS-induced inflammation, as indicated by improved disease activity indices and colon histology, as well as decreased intestinal tissue myeloperoxidase levels and plasma TNFα and IL-6 concentrations. " 04/01/2016 - "demonstrate that 5A peptide can inhibit CD36 signaling, attenuate chronic kidney disease progression, and ameliorate inflammation and tubulointerstitial fibrosis by reducing the expression of inflammatory cytokines and chemokines, suggesting the therapeutic potential of 5A peptide against CD36-mediated renal injury. "
2.	Chronic Renal Insufficiency 04/01/2016 - "demonstrate that 5A peptide can inhibit CD36 signaling, attenuate chronic kidney disease progression, and ameliorate inflammation and tubulointerstitial fibrosis by reducing the expression of inflammatory cytokines and chemokines, suggesting the therapeutic potential of 5A peptide against CD36-mediated renal injury. "
3.	Fibrosis (Cirrhosis) 04/01/2016 - "demonstrate that 5A peptide can inhibit CD36 signaling, attenuate chronic kidney disease progression, and ameliorate inflammation and tubulointerstitial fibrosis by reducing the expression of inflammatory cytokines and chemokines, suggesting the therapeutic potential of 5A peptide against CD36-mediated renal injury. "
4.	Colitis 01/01/2016 - "The 5A peptide is effective at ameliorating murine colitis by preventing intestinal monocyte infiltration and activation. "
5.	Asthma (Bronchial Asthma) 01/01/2011 - "A 5A peptide, which is a synthetic, bihelical apoA-I mimetic, was administered to wild-type A/J mice via osmotic mini-pump prior to the induction of house dust mite (HDM)-induced asthma. "

Related Drugs and Biologics

1.	Apolipoprotein A-I (Apolipoprotein A1)
2.	Interleukin-6 (Interleukin 6)
3.	Peroxidase (Myeloperoxidase)
4.	Chemokines
5.	Cytokines