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CCT245737

a CHK1 inhibitor; structure in first source

Also Known As:

5-((4-((morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrazines: 150
    - CCT245737: 1
  - Pyridines: 88
    - Aminopyridines: 77
      - 4-Aminopyridine: 703
        CCT245737: 1
Organic Chemicals: 133
- Amines: 4871
  - Aminopyridines: 77
    - 4-Aminopyridine: 703
      - CCT245737: 1

Experts

1.	Aherne, G Wynne: 1 article (01/2016)
2.	Box, Gary: 1 article (01/2016)
3.	Boxall, Kathy J: 1 article (01/2016)
4.	Collins, Ian: 1 article (01/2016)
5.	De Haven Brandon, Alexis K: 1 article (01/2016)
6.	Eccles, Suzanne A: 1 article (01/2016)
7.	Eve, Paul D: 1 article (01/2016)
8.	Garrett, Michelle D: 1 article (01/2016)
9.	Hayes, Angela: 1 article (01/2016)
10.	Henley, Alan T: 1 article (01/2016)

Related Diseases

1.	B-Cell Lymphoma (Lymphoma, B Cell) 01/19/2016 - "Finally, CCT245737 also showed significant single-agent activity against a MYC-driven mouse model of B-cell lymphoma. " 01/19/2016 - "The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eµ-MYC driven B-cell lymphoma."
2.	Neoplasms (Cancer) 01/19/2016 - "Furthermore, development of a novel ELISA assay for pS296 CHK1 autophosphorylation, allowed the quantitative measurement of target inhibition in a RAS mutant human tumor xenograft of NSCLC at efficacious doses of CCT245737. " 01/19/2016 - "Genotoxic-induced CHK1 activity (pS296 CHK1) and cell cycle arrest (pY15 CDK1) were inhibited both in vitro and in human tumor xenografts by CCT245737, causing increased DNA damage and apoptosis. " 01/19/2016 - "CCT245737 potently inhibited cellular CHK1 activity (IC50 30-220 nM) and enhanced gemcitabine and SN38 cytotoxicity in multiple human tumor cell lines and human tumor xenograft models. "

Related Drugs and Biologics

1.	Gemcitabine