Zj6413

a poly(ADP-ribose) polymerase inhibitor with antineoplastic activity; structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

1.	Triple Negative Breast Neoplasms 05/01/2016 - "As expected, the Zj6413 showed notable anti-tumor activity against breast cancer gene (BRCA) deficient triple negative breast cancers (TNBCs). "
2.	Neoplasms (Cancer) 05/01/2016 - "Zj6413 also induced G2/M arrest and cell death in the MX-1, MDA-MB-453 BC cells, exerted chemo-sensitizing effect on BRCA proficient cancer cells and potentiated Temozolomide (TMZ)'s cytotoxicity in MX-1 xenograft tumors mice. " 05/01/2016 - "As expected, the Zj6413 showed notable anti-tumor activity against breast cancer gene (BRCA) deficient triple negative breast cancers (TNBCs). " 05/01/2016 - "Zj6413 treated breast cancers (BCs) showed an elevated level of DNA damage evidenced by the accumulation of γ-H2AX foci and DNA damaged related proteins. "
3.	Breast Neoplasms (Breast Cancer) 05/01/2016 - "Poly (ADP-ribose) polymerases inhibitor, Zj6413, as a potential therapeutic agent against breast cancer." 05/01/2016 - "As expected, the Zj6413 showed notable anti-tumor activity against breast cancer gene (BRCA) deficient triple negative breast cancers (TNBCs). "

1.	Proteins (Proteins, Gene)
2.	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
3.	DNA (Deoxyribonucleic Acid)
4.	Temozolomide (Temodar)