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tazarotenic acid

active metabolite of tazarotene; structure in first source

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 207
- 1-Ring Heterocyclic Compounds
  - Pyridines: 91
    - Nicotinic Acids: 13
      - tazarotenic acid: 5
- Heterocyclic Acids
  - Nicotinic Acids: 13
    - tazarotenic acid: 5

Experts

1.	Sefton, John: 2 articles (01/2003 - 11/2002)
2.	Hamzehpour, Helena: 1 article (12/2023)
3.	Jónsdóttir, Fjóla: 1 article (12/2023)
4.	Jónsson, Helgi: 1 article (12/2023)
5.	Sigurjónsson, Ólafur E: 1 article (12/2023)
6.	Snorradottir, Bergthora S: 1 article (12/2023)
7.	Óskarsdóttir, Ástrós: 1 article (12/2023)
8.	Allenby, Kent: 1 article (09/2019)
9.	Gautam, Anirudh: 1 article (09/2019)
10.	Okumu, Franklin: 1 article (09/2019)

Related Diseases

1.	Acne Vulgaris 01/01/2003 - "At standard application rates in patients with acne vulgaris, the maximum average C(max) and AUC values of tazarotenic acid were 0.10 +/- 0.06 microg/L (n = 8) and 1.54 +/- 1.01 microg. " 01/01/2003 - "At exaggerated application rates in patients with acne vulgaris, the maximum average peak concentration (C(max)) and 24-hour area under the concentration-time curve (AUC) values of tazarotenic acid were (mean +/- SD) 1.20 +/- 0.41 microg/L (n = 10) and 17.0 +/- 6.1 microg. " 09/01/2019 - "Objective: Two clinical studies were conducted to 1) assess the pharmacokinetic (PK) properties of tazarotene and tazarotenic acid in DFD-03 lotion (a 1-minute, short-contact formulation for the topical treatment of acne vulgaris) and tazarotene cream 0.1% and 2) to evaluate transepidermal water loss (TEWL) with DFD-03 lotion, tazarotene gel (0.1%), or vehicle. "
2.	Osteoarthritis 12/31/2023 - "The detection of tazarotene and tazarotenic acid in both the in vitro permeation studies and the pilot study on porcine joints validate the drug's potential therapeutic use for hand osteoarthritis. "
3.	Actinic Keratosis 11/01/2002 - "Also, lentigines, elastosis, pore size, irregular depigmentation, tactile roughness, coarse wrinkling, telangiectasia, actinic keratoses, overall integrated assessment of photodamage, global response to treatment, patients' overall assessment of photodamage, and plasma levels of tazarotenic acid. "
4.	Telangiectasis (Telangiectasia) 11/01/2002 - "Also, lentigines, elastosis, pore size, irregular depigmentation, tactile roughness, coarse wrinkling, telangiectasia, actinic keratoses, overall integrated assessment of photodamage, global response to treatment, patients' overall assessment of photodamage, and plasma levels of tazarotenic acid. "
5.	Lentigo (Lentiginosis) 11/01/2002 - "Also, lentigines, elastosis, pore size, irregular depigmentation, tactile roughness, coarse wrinkling, telangiectasia, actinic keratoses, overall integrated assessment of photodamage, global response to treatment, patients' overall assessment of photodamage, and plasma levels of tazarotenic acid. "

Related Drugs and Biologics

1.	tazarotene (Tazorac)
2.	Therapeutic Uses
3.	diformyl dapsone (DFD)
4.	Prodrugs