N-Myc Proto-Oncogene Protein

A basic helix-loop-helix leucine zipper (bHLHZ) transcription factor and proto-oncogene protein that functions in cell growth and proliferation. In mammals, it is highly expressed in the brain during embryogenesis and is essential for brain development; it is not expressed in adult tissues. Amplification or overexpression of N-Myc occurs in at least 20% of tumors and is associated with a poor prognosis in cases of NEUROBLASTOMA; ALVEOLAR RHABDOMYOSARCOMA; SMALL CELL LUNG CARCINOMA; and neuroendocrine prostate cancer.

Also Known As:

BHLHE37 Protein; Class E Basic Helix-Loop-Helix Protein 37; MYCN Protein; N-Myc Protein; NMYC Protein; Class E Basic Helix Loop Helix Protein 37; N Myc Protein; N Myc Proto Oncogene Protein; Proto-Oncogene Protein, N-Myc

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - Basic Helix-Loop-Helix Transcription Factors: 510
      - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors: 3
        N-Myc Proto-Oncogene Protein: 108
    - Basic-Leucine Zipper Transcription Factors: 187
      - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors: 3
        N-Myc Proto-Oncogene Protein: 108
  - DNA-Binding Proteins: 2009
    - Basic Helix-Loop-Helix Transcription Factors: 510
      - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors: 3
        N-Myc Proto-Oncogene Protein: 108
    - Basic-Leucine Zipper Transcription Factors: 187
      - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors: 3
        N-Myc Proto-Oncogene Protein: 108
  - Neoplasm Proteins: 2
    - Oncogene Proteins: 7793
      - Proto-Oncogene Proteins: 7
        N-Myc Proto-Oncogene Protein: 108

rat Mycn protein

Bio-Agent Context: Research Results