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VEL-0230

a cathepsin K antagonist

Also Known As:

NC-2300; monosodium 3-((1-isobutoxymethyl-3-methylbutyl)carbamoyl)oxirane-2-carboxylate

Networked: 4 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ethers: 242
  - Cyclic Ethers: 12
    - Epoxy Compounds: 689
      - VEL-0230: 4

Experts

1.	Azab, Mohamed: 1 article (01/2017)
2.	Bertone, Alicia L: 1 article (01/2017)
3.	Boyaka, Prosper: 1 article (01/2017)
4.	Dulin, Jennifer: 1 article (01/2017)
5.	Hussein, Hayam: 1 article (01/2017)
6.	Russell, Duncan: 1 article (01/2017)
7.	Smanik, Lauren: 1 article (01/2017)
8.	Kawashima, Nobuyuki: 1 article (09/2015)
9.	Suzuki, Noriyuki: 1 article (09/2015)
10.	Takimoto, Koyo: 1 article (09/2015)

Related Diseases

1.	Arthritis (Polyarthritis) 05/01/2013 - "A CTS inhibitor, NC-2300, not only suppresses bone erosion by inhibition of cathepsin K (CTSK), but also ameliorates paw swelling at inflamed joints in adjuvant-induced arthritis in rats. " 09/01/2015 - "NC-2300 is an artificially designed cathepsin K inhibitor, and its application to experimentally induced arthritis induces down-regulation of bone destruction. "
2.	Inflammation (Inflammations) 09/01/2015 - "In this study, we evaluated the effects of NC-2300 on inflammation and bone destruction in experimentally induced rat periapical lesions. " 05/01/2013 - "It has been demonstrated that the amelioration of joint inflammation by NC-2300 is mediated by the downregulation of cytokine expression in dendritic cells, which are essential for Th17 activation. "
3.	Bone Resorption 12/01/2014 - "Weekly administration of VEL-0230 may provide effective inhibition of bone resorption in young exercising horses that returns to baseline within 7 days after drug withdrawal even after multiple doses." 01/01/2017 - "VEL-0230 is a highly selective inhibitor of CatK that significantly decreased bone resorption and increased bone formation biomarkers. "
4.	Psoriasis (Pustulosis Palmaris et Plantaris) 05/01/2013 - "Topical treatment with NC-2300 significantly ameliorated 12-O-tetradecanoylphorbol-13-acetate-induced psoriasis-like lesions in K5.Stat3C mice, and downregulated the expression of IL-12, IL-23, and Th17 cytokines. "

Related Drugs and Biologics

1.	Cathepsin K
2.	Interleukin-23 (Interleukin 23)
3.	Interleukin-12 (IL 12)
4.	Cytokines
5.	Biomarkers (Surrogate Marker)