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SAR405

a Vps34 inhibitor with antineoplastic activity; structure in first source

Networked: 9 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - SAR405: 9
  - Pyridines: 88
    - SAR405: 9

Experts

1.	Pasquier, Benoit: 2 articles (04/2015 - 12/2014)
2.	Carraro, Fabio: 1 article (01/2022)
3.	Coppola, Federica: 1 article (01/2022)
4.	Filippi, Irene: 1 article (01/2022)
5.	Giuntini, Gaia: 1 article (01/2022)
6.	Marotta, Giuseppe: 1 article (01/2022)
7.	Monaci, Sara: 1 article (01/2022)
8.	Naldini, Antonella: 1 article (01/2022)
9.	Rossi, Daniela: 1 article (01/2022)
10.	Sozzani, Silvano: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 04/03/2015 - "SAR405, a PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells." 04/03/2015 - "Finally our results show that combining SAR405 with everolimus, the FDA-approved MTOR inhibitor, results in a significant synergy on the reduction of cell proliferation using renal tumor cells. " 12/01/2014 - "Moreover, we show that the concomitant inhibition of Vps34 and mTOR, with SAR405 and the US Food and Drug Administration-approved mTOR inhibitor everolimus, results in synergistic antiproliferative activity in renal tumor cell lines, indicating a potential clinical application in cancer." 01/01/2020 - "We showed that genetic or pharmacological inhibition of Vps34 kinase activity using SB02024 or SAR405 (Vps34i) decreased the tumor growth and improved mice survival in multiple tumor models by inducing an infiltration of NK, CD8+, and CD4+ T effector cells in melanoma and CRC tumors. "
2.	Melanoma (Melanoma, Malignant) 01/01/2020 - "We showed that genetic or pharmacological inhibition of Vps34 kinase activity using SB02024 or SAR405 (Vps34i) decreased the tumor growth and improved mice survival in multiple tumor models by inducing an infiltration of NK, CD8+, and CD4+ T effector cells in melanoma and CRC tumors. "
3.	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/01/2019 - "The present study suggests that SAR405 can prevent the memory consolidation via intervening autophagy and GABAAR trafficking and has a potential therapeutic value for disorders characterized by exaggerated fear memories, such as posttraumatic stress disorder."
4.	Cardiotoxicity 12/01/2023 - "Intriguingly, the combination of DEX and SAR405 protected cells against DOX-induced cardiotoxicity in vivo. " 12/01/2023 - "Targeting autophagy with SAR405 alleviates doxorubicin-induced cardiotoxicity."
5.	Disease Progression 01/01/2021 - "Further, administration of SAR405, a selective PIK3C3 inhibitor, delayed disease progression. "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Everolimus
3.	Caspase 9
4.	Caspase 3 (Caspase-3)
5.	Sirolimus (Rapamycin)
6.	Cytokines
7.	Proteins (Proteins, Gene)
8.	Doxorubicin (Adriamycin)
9.	1- ((2- ((2- chloropyridin- 4yl)amino)- 4'- (cyclopropylmethyl)- (4,5'- bipyrimidin)- 2'- yl)amino)- 2- methylpropan- 2- ol