apcin

12/01/2021 - "Furthermore, apcin improved glioma sensitivity to TMZ. "
12/01/2021 - "In this study, a series of biochemical assays, such as Cell Counting Kit-8 (CCK-8), wound healing, apoptosis and colony formation assays, were performed to determine the antitumor properties of apcin in glioma cells. "
12/01/2021 - "Increased Bim expression indicated that apcin promotes the apoptosis of glioma cells. "
12/01/2021 - "The results showed that apcin significantly inhibited the proliferation of glioma cells in a time- and dose-dependent manner. "
12/01/2021 - "The purpose of this article was to assess whether apcin inhibits tumor growth in glioma cell lines and increases the sensitivity of GBM to TMZ. "

04/30/2022 - "Preclinical findings showed that selective CDC20 and APC/CCDC20/APC/CCDH1 inhibitors, namely Apcin and proTAME, are effective against lymphoma and multiple myeloma cells, resulting in mitotic arrest and apoptosis and synergizing with clinically-relevant drugs. "

04/30/2022 - "Preclinical findings showed that selective CDC20 and APC/CCDC20/APC/CCDH1 inhibitors, namely Apcin and proTAME, are effective against lymphoma and multiple myeloma cells, resulting in mitotic arrest and apoptosis and synergizing with clinically-relevant drugs. "

03/07/2023 - "Administration of nutlin-3a/apcin alone or in combination confirmed their efficacy and safety in tumor-bearing mice. "
02/15/2023 - "Discovery of Ureido-Based Apcin Analogues as Cdc20-specific Inhibitors against Cancer."
01/01/2020 - "Among these derivatives, compound 9f was much more efficient than the positive compound apcin in inhibiting cancer cell growth, but it had approximately the same binding affinity with apcin in SPR assays. "
01/01/2019 - "Small-molecule inhibition of the APC/C reduced viability of both CSCs and nonstem tumor cells (NSTCs), with the combination of proTAME and apcin having the biggest impact. "
12/01/2021 - "The purpose of this article was to assess whether apcin inhibits tumor growth in glioma cell lines and increases the sensitivity of GBM to TMZ. "

02/10/2022 - "When evaluated in MDA-MB-231 and MDA-MB-468 triple negative breast cancer cell lines, several analogs showed 5-10-fold improvement over apcin with IC50 values at ∼10 μM in cell viability assays. "