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2,7- dioxo- 2,7- dihydro- 3H- naphtho(1,2,3- de)quinoline- 1- carboxylate

inhibits apoptosis signal-regulating kinase 1; structure in first source

Also Known As:

NQDI 1; NQDI-1

Networked: 7 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Benzylisoquinolines: 151
    - Aporphines: 10
      - 2,7-dioxo-2,7-dihydro-3H-naphtho(1,2,3-de)quinoline-1-carboxylate: 7
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - 2,7-dioxo-2,7-dihydro-3H-naphtho(1,2,3-de)quinoline-1-carboxylate: 7
    - Isoquinolines: 34
      - Benzylisoquinolines: 151
        Aporphines: 10
        2,7-dioxo-2,7-dihydro-3H-naphtho(1,2,3-de)quinoline-1-carboxylate: 7
  - 4 or More Rings Heterocyclic Compounds
    - Aporphines: 10
      - 2,7-dioxo-2,7-dihydro-3H-naphtho(1,2,3-de)quinoline-1-carboxylate: 7

Experts

1.	Chen, Weiwei: 1 article (11/2019)
2.	Ding, Yanbing: 1 article (11/2019)
3.	Gong, Weijuan: 1 article (11/2019)
4.	Li, Weiqin: 1 article (11/2019)
5.	Lu, Guotao: 1 article (11/2019)
6.	Ma, Nan: 1 article (11/2019)
7.	Xiao, Weiming: 1 article (11/2019)
8.	Xie, Xiaochun: 1 article (11/2019)
9.	Xu, Zhenglei: 1 article (11/2019)
10.	Yin, Ling: 1 article (11/2019)

Related Diseases

1.	Renal Insufficiency (Renal Failure) 09/01/2013 - "The present study evaluated the renal protective effects of NQDI 1, an inhibitor of ASK1, in an animal model of acute ischemic renal failure. "
2.	Reperfusion Injury 09/01/2013 - "The administration of NQDI 1 attenuated renal dysfunction and histological changes characteristic for renal ischemia/reperfusion injury (IRI). " 09/12/2019 - "The aim is to explore the mechanism of the apoptosis signal-regulating kinase-1 (ASK-1) signaling pathway and the involvement of the thioredoxin (Trx) system during testicular ischemia reperfusion injury (tIRI) by using ASK-1 specific inhibitor, NQDI-1. "
3.	Acute Necrotizing Pancreatitis 11/26/2019 - "Taken together, these findings showed that NQDI-1 could reduce the acinar cells necrosis and alleviate the severity of AP, which may afford a new therapeutic target on pancreatic necrosis in AP clinically."
4.	Pancreatitis 11/26/2019 - "However, the role of NQDI-1 in acute pancreatitis (AP) has not been reported. " 11/26/2019 - "NQDI-1 protects against acinar cell necrosis in three experimental mouse models of acute pancreatitis."
5.	Postoperative Pain 02/03/2023 - "MMP-9 knockout and the ASK1 inhibitor, NQDI-1, attenuated postoperative pain. "

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