HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

1- (4- hydroxyphenylethyl)- 6,7- dihydroxy- 1,2,3,4- tetrahydroisoquinoline

induces expression of HO-1 by stimulating Nrf2-ARE binding activity; structure in first source

Also Known As:

THI-28

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - 1-(4-hydroxyphenylethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline: 1

Experts

1.	Chang, Ki Churl: 1 article (11/2013)
2.	Kim, Hee Sook: 1 article (11/2013)
3.	Kim, Hye Jung: 1 article (11/2013)
4.	Park, Eun Jung: 1 article (11/2013)
5.	Park, Sang Won: 1 article (11/2013)

Related Diseases

1.

Sepsis (Septicemia)

11/01/2013 - "Taken together, these findings suggest that the novel compound THI-28 induces the expression of HO-1 by activating the PI3K and p38 MAPK pathways and suppressed HMGB1 and iNOS production in LPS-treated macrophages and septic mice, which may be useful in treating organ injury due to sepsis. "
11/01/2013 - "We investigated whether THI-28 [1-4-(hydroxyphenylethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline] inhibits release of high mobility group box 1 (HMGB1), a late phase cytokine of sepsis, in lipopolysaccharide (LPS)-stimulated RAW264.7 cells through heme oxygenase (HO)-1 induction so that it shows beneficial effects in the cecal ligation and puncture (CLP)-induced septic mouse model. "

Related Drugs and Biologics

1.	p38 Mitogen-Activated Protein Kinases
2.	HMGB1 Protein (HMG1)
3.	Cytokines
4.	Lipopolysaccharides
5.	Heme Oxygenase (Decyclizing) (Heme Oxygenase)
6.	1,2,3,4-tetrahydroisoquinoline

Related Therapies and Procedures

1.	Punctures
2.	Ligation