afoxolaner

04/02/2014 - "Treatment with afoxolaner resulted in efficacies of 98.8-100% within 48 h on existing tick infestations, while the efficacy against new tick infestations was >95.7% over five weeks."
12/01/2019 - "The second trial assessed the efficacy of afoxolaner for treating dogs with heavy tick infestations (>500 ticks/dog), including four dogs from two households. "
09/26/2014 - "Afoxolaner starts to kill the pre-existing tick infestations rapidly with an immediate efficacy of 93.4% and 100% respectively at 12 h and 24 h post treatment. "
04/02/2014 - "Afoxolaner rapidly eliminated pre-existing tick infestations (100% ticks killed within 48 h of treatment) and controlled weekly re-infestations (91.9% prophylactic efficacy at Day 30)."
04/02/2014 - "Afoxolaner, administered at an average dose of 2.7 mg/kg bodyweight (range 2.5-2.9 mg/kg), rapidly eliminated the pre-existing tick infestations with over 99% acaricidal efficacy and controlled the weekly re-infestations for up to 30 days post treatment with over 96% efficacy on both tick species. "

07/30/2016 - "The results of these controlled studies demonstrate the high efficacy of the afoxolaner plus milbemycin oxime chewables against a broad range of canine intestinal nematode infections. "
07/30/2016 - "The efficacy of oral afoxolaner plus milbemycin oxime combination chewables against induced gastrointestinal nematode infections in dogs was evaluated in six separate studies. "
07/30/2016 - "Efficacy of oral afoxolaner plus milbemycin oxime chewables against induced gastrointestinal nematode infections in dogs."
01/01/2017 - "Afoxolaner (AFX) plus milbemycin oxime (MO) combination chewable tablets (NexGard Spectra®, Merial) were evaluated for safety and efficacy against naturally acquired nematode infections in domestic dogs in a multi-centre, positive control, blinded field study using a randomized block design based on the order of presentation for allocation. "
02/15/2016 - "The efficacy of oral afoxolaner plus milbemycin oxime combination chewable tablets (NexGard Spectra, Merial) against naturally acquired intestinal nematode infections in dogs was evaluated in six negative control, blinded studies including a total of 114 dogs. "

01/01/2021 - "Efficacy of afoxolaner (NexGard®) on the treatment of myiasis caused by the New World screwworm fly Cochliomyia hominivorax (Diptera: Calliphoridae) in naturally infested dogs."
12/01/2023 - "Efficacy of the combination of milbemycin oxime and afoxolaner for the control of myiasis by Musca domestica in desert tortoises (Gopherus berlandieri)."
01/01/2021 - "hominivorax larvae, were treated with afoxolaner (NexGard®) as per label recommendations, providing at least the minimum dosage of 2.5 mg/kg. Maggot infestations were classified as light (fewer than 10 larvae), mild (from 10 to 20 larvae) or severe (more than 20 larvae), according to the number of larvae found in the wound and/or collected from the ground after treatment. "
05/06/2018 - "The comparative efficacy of afoxolaner, spinosad, milbemycin, spinosad plus milbemycin, and nitenpyram for the treatment of canine cutaneous myiasis."

05/30/2018 - "It was found that afoxolaner was effective in the treatment of otodectic mange the animals presented no adverse reaction to the use of afoxolaner."
05/30/2018 - "The objective of this study was to evaluate the efficacy of afoxolaner in the treatment of otodectic mange in naturally infested cats. "
12/01/2021 - "Efficacy of afoxolaner for the treatment of ear mite infestation under field conditions."
05/30/2018 - "Efficacy of afoxolaner in the treatment of otodectic mange in naturally infested cats."

01/01/2016 - "Three monthly doses of the afoxolaner chewable also eliminated flea infestations in dogs, markedly reduced premises' flea populations and similarly improved dermatology lesions and pruritus."
01/01/2016 - "Evaluation of fluralaner and afoxolaner treatments to control flea populations, reduce pruritus and minimize dermatologic lesions in naturally infested dogs in private residences in west central Florida USA."
07/01/2020 - "The single oral treatment of afoxolaner plus milbemycin oxime resulted in a significant reduction in pruritus of 87.4% at 28 d after treatment (P ≤ 0.05). "