platyphylloside

from the bark of black alder, inhibits the growth of sensitive and multi-drug resistant non-small cell lung carcinoma cells; structure in first source

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cho, Namki: 3 articles (08/2019 - 11/2012)
2.	Sung, Sang Hyun: 3 articles (10/2016 - 11/2012)
3.	Kim, Tae Bum: 2 articles (05/2016 - 11/2012)
4.	Lee, Jina: 1 article (08/2019)
5.	Lee, Joo-Eun: 1 article (08/2019)
6.	Thuy, Nguyen Thi Thanh: 1 article (08/2019)
7.	Yoo, Hee Min: 1 article (08/2019)
8.	Lee, Mina: 1 article (10/2016)
9.	Beutler, John A: 1 article (05/2016)
10.	Kim, Hyun Woo: 1 article (05/2016)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2014 - "Diarylheptanoids with a p-coumaroyl group, 14 and 18, platyphylloside (1), platyphyllonol-5-O-β-D-xylopyranoside (2), alnuside B (4) and hirsutenone (9) exhibited strong anti-cancer activity, considerably higher than diarylheptanoid curcumin, which served as a positive control. " 10/01/2008 - "The diarylheptanoids (1-10) 1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-O-beta-D-glucopyranosyl(1-->3)-beta-D-xylopyranoside (1), 1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-O-beta-D-apiofuranosyl(1-->6)-beta-D-glucopyranoside (2), 1,7-bis-(3,4-dihydroxyphenyl)-heptane-5-O-beta-D-glucopyranoside (3), 1,7-bis-(3,4-dihydroxyphenyl)-5-hydroxyheptane (4), 1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-one-5-O-beta-D-glucopyranoside (5), oregonin (6), hirsutanonol (7), hirsutenone (8), 1,7-bis-(3,4-dihydroxyphenyl)-5-hydroxyheptane-3-O-beta-D-xylopyranoside (9), and platyphylloside (10), isolated from the bark of Alnus japonica, were analyzed for their cytotoxic activities on various human and mouse cancer cell lines. "
2.	Colonic Neoplasms (Colon Cancer) 08/15/2019 - "Platyphylloside Isolated from Betula platyphylla is Antiproliferative and Induces Apoptosis in Colon Cancer and Leukemic Cells." 05/28/2016 - "A simple and rapid method using high-speed counter-current chromatography (HSCCC), along with bioassay-guided fractionation based on the anti-proliferative activity against renal and colon cancer cells, has been developed for the preparative separation of aceroside VIII (1) and platyphylloside (2) from Betula platyphylla. "
3.	Osteosarcoma (Osteogenic Sarcoma) 05/28/2016 - "Among these isolated diarylheptanoids, platyphylloside (2) showed anti-proliferative activity in the COLO205 and KM12 colon cells and renal cancer cell lines A498, U031, as well as in MG63 and MG 63.3 osteosarcoma cells. "
4.	Obesity 10/01/2016 - "Taken together, the results reveal that platyphylloside has anti-adipogenic activity and highlight its potential in the prevention and treatment of obesity. "
5.	Memory Disorders (Memory Loss) 11/15/2012 - "platyphylla bark and platyphylloside may ameliorate memory deficits by activating the CREB-BDNF pathway and prevent a neurodegeneration by inhibiting neuronal cell death."

Related Drugs and Biologics

1.	Diarylheptanoids
2.	hirsutenone
3.	aceroside VIII
4.	Brain-Derived Neurotrophic Factor (BDNF)
5.	Scopolamine (Hyoscine)
6.	Heptanes
7.	Curcumin
8.	hirsutanonol
9.	oregonin
10.	alnuside B