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Manhui Zhu Selected Research

Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)

3/2024Tocilizumab attenuates choroidal neovascularization by regulating macrophage polarization through the IL-6R/STAT3/VEGF pathway.
1/2021The HIF-1α/p53/miRNA-34a/Klotho axis in retinal pigment epithelial cells promotes subretinal fibrosis and exacerbates choroidal neovascularization.
11/2020Fruquintinib inhibits VEGF/VEGFR2 axis of choroidal endothelial cells and M1-type macrophages to protect against mouse laser-induced choroidal neovascularization.
1/2020Prodrug of epigallocatechin-3-gallate alleviates choroidal neovascularization via down-regulating HIF-1α/VEGF/VEGFR2 pathway and M1 type macrophage/microglia polarization.
12/2018YAP via interacting with STAT3 regulates VEGF-induced angiogenesis in human retinal microvascular endothelial cells.
1/2018Inhibition of TRAF6 alleviates choroidal neovascularization in vivo.
1/2016Inhibition of RACK1 ameliorates choroidal neovascularization formation in vitro and in vivo.
1/2016Tissue factor induces VEGF expression via activation of the Wnt/β-catenin signaling pathway in ARPE-19 cells.
1/2016PKR promotes choroidal neovascularization via upregulating the PI3K/Akt signaling pathway in VEGF expression.

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Manhui Zhu Research Topics

Disease

16Choroidal Neovascularization
03/2024 - 01/2016
12Hypoxia (Hypoxemia)
11/2023 - 01/2016
8Diabetic Retinopathy (Retinopathy, Diabetic)
12/2022 - 01/2019
5Inflammation (Inflammations)
12/2024 - 10/2020
4Neoplasms (Cancer)
10/2020 - 11/2015
3Hyperglycemia
01/2021 - 11/2020
3Gliosis
11/2020 - 01/2019
2Fibrosis (Cirrhosis)
01/2023 - 01/2021
2Pathologic Neovascularization
02/2022 - 12/2018
2Macular Degeneration (Age-Related Maculopathy)
01/2021 - 06/2019
2Blindness (Hysterical Blindness)
10/2020 - 12/2018
2AIDS-Related Complex (ARC)
10/2020 - 01/2018
2Cataract (Cataracts)
10/2020 - 01/2018
2Ganglion Cysts (Ganglion)
01/2020 - 05/2019
2Retinal Degeneration
11/2015 - 06/2015
1Virus Diseases (Viral Diseases)
12/2024
1Diabetes Complications
01/2021
1Toxic Optic Neuropathy
11/2020
1Microaneurysm
10/2020
1Body Weight Changes
10/2020
1Age-Related Nuclear Cataract
01/2018

Drug/Important Bio-Agent (IBA)

12Retinaldehyde (Retinal)IBA
01/2021 - 06/2015
9Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
03/2024 - 01/2016
3Transcription Factors (Transcription Factor)IBA
11/2023 - 08/2020
3EnzymesIBA
05/2021 - 11/2015
3NF-kappa B (NF-kB)IBA
05/2021 - 08/2020
2Long Noncoding RNAIBA
09/2023 - 10/2020
2InflammasomesIBA
02/2022 - 08/2020
2Retinal Pigments (Pigments, Visual)IBA
02/2022 - 01/2021
2MelatoninIBA
05/2021 - 11/2020
2Sirtuin 1IBA
05/2021 - 11/2020
2AntioxidantsIBA
05/2021 - 01/2021
2geniposideIBA
01/2021 - 01/2021
2Proteins (Proteins, Gene)FDA Link
10/2020 - 08/2020
2Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
01/2020 - 01/2020
2cobaltous chloride (cobalt(II)chloride)IBA
01/2016 - 01/2016
1Nucleic AcidsIBA
12/2024
1tocilizumab (atlizumab)FDA Link
03/2024
1LycopeneIBA
01/2023
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
12/2022
1Interleukin-11 (Interleukin 11)IBA
12/2022
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
12/2022
1shikoninIBA
12/2021
16- chloro- 2,3,4,9- tetrahydro- 1H- carbazole- 1- carboxamideIBA
05/2021
1MicroRNAs (MicroRNA)IBA
01/2021
1Mechanistic Target of Rapamycin Complex 1IBA
01/2021
1Heparin-binding EGF-like Growth Factor (HB-EGF)IBA
01/2021
1HMPL-013IBA
11/2020
1Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
11/2020
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
11/2020
1luzindoleIBA
11/2020
1CytokinesIBA
11/2020
1Hormones (Hormone)IBA
11/2020
1Blood Glucose (Blood Sugar)IBA
10/2020
1pevonedistatIBA
10/2020
1Glucose (Dextrose)FDA LinkGeneric
08/2020
1Member 2 Group A Nuclear Receptor Subfamily 4IBA
08/2020
1ProdrugsIBA
01/2020
1TeaIBA
01/2020
1Proto-Oncogene Proteins c-metIBA
01/2020
1Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA
01/2020
1cabozantinibIBA
01/2020
1tyrosine receptor (receptor, tyrosine)IBA
01/2020
1epigallocatechin gallate (epigallocatechin-3-gallate)IBA
01/2020
1Phosphotransferases (Kinase)IBA
01/2020
1Small Interfering RNA (siRNA)IBA
06/2019
1oxalylglycineIBA
12/2018
1Oxygen (Dioxygen)IBA
12/2018
1lanosterol synthaseIBA
01/2018
1LanosterolIBA
01/2018
1Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA
01/2018
1TNF Receptor-Associated Factor 6 (TRAF6)IBA
01/2018
1eIF-2 Kinase (eIF 2 Kinase)IBA
01/2016
1Pyruvate KinaseIBA
11/2015
1Pyruvic Acid (Pyruvate)IBA
11/2015
1Adenosine Triphosphate (ATP)IBA
11/2015
1IsoenzymesIBA
11/2015

Therapy/Procedure

8Lasers (Laser)
11/2023 - 01/2020
2Intravitreal Injections
01/2021 - 11/2020
1Therapeutics
01/2021
1Intraperitoneal Injections
10/2020