Ulrich M Zanger Selected Research

Hepatocellular Carcinoma (Hepatoma)

12/2020	Polycyclic Aromatic Hydrocarbons Activate the Aryl Hydrocarbon Receptor and the Constitutive Androstane Receptor to Regulate Xenobiotic Metabolism in Human Liver Cells.
11/2015	Comparative Analysis and Functional Characterization of HC-AFW1 Hepatocarcinoma Cells: Cytochrome P450 Expression and Induction by Nuclear Receptor Agonists.
11/2015	Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms.
12/2011	DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma.
10/2006	A silent mutation (2939G>A, exon 6; CYP2D6*59) leading to impaired expression and function of CYP2D6.

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Ulrich M Zanger Research Topics

Disease

7	Inflammation (Inflammations) 01/2020 - 01/2010
7	Neoplasms (Cancer) 01/2020 - 05/2013
5	Hepatocellular Carcinoma (Hepatoma) 12/2020 - 10/2006
5	Cholestasis 01/2020 - 10/2009
4	Breast Neoplasms (Breast Cancer) 01/2021 - 11/2007
4	Non-alcoholic Fatty Liver Disease 01/2018 - 01/2013
3	Acute-Phase Reaction 01/2020 - 02/2015
2	Carcinogenesis 01/2020 - 01/2017
2	Liver Diseases (Liver Disease) 01/2020 - 01/2016
2	Colorectal Neoplasms (Colorectal Cancer) 04/2014 - 03/2008
2	Acquired Immunodeficiency Syndrome (AIDS) 05/2013 - 09/2010
2	Drug-Related Side Effects and Adverse Reactions 07/2007 - 08/2002
2	Body Weight (Weight, Body) 07/2006 - 08/2005
2	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 03/2005 - 01/2005
1	Alcoholic Fatty Liver 01/2020
1	Kernicterus 01/2018
1	Fibrosis (Cirrhosis) 01/2018
1	Hyperbilirubinemia 01/2018
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2018
1	Thyroid Neoplasms (Thyroid Cancer) 12/2016
1	Thyroid Diseases (Thyroid Disease) 12/2016
1	Feminization 01/2016
1	Dihydropyrimidine Dehydrogenase Deficiency 12/2015
1	Disease Progression 11/2015
1	Fatty Liver 11/2015
1	Ovarian Neoplasms (Ovarian Cancer) 06/2015
1	Carcinoma (Carcinomatosis) 01/2015
1	Tuberculosis (Tuberculoses) 07/2014
1	Infections 01/2014
1	Muscular Diseases (Myopathy) 01/2013
1	Insulin Resistance 01/2013
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2013
1	Coronary Artery Disease (Coronary Atherosclerosis) 01/2011
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2011

Drug/Important Bio-Agent (IBA)

7	Proteins (Proteins, Gene)FDA Link 12/2020 - 10/2006
6	EnzymesIBA 01/2020 - 03/2005
5	LipidsIBA 01/2021 - 01/2011
5	Cytochrome P-450 CYP2B6 (CYP2B6)IBA 12/2020 - 07/2006
4	BilirubinIBA 01/2018 - 01/2011
3	C-Reactive ProteinIBA 01/2020 - 01/2011
3	MicroRNAs (MicroRNA)IBA 01/2020 - 01/2014
3	Hormones (Hormone)IBA 01/2020 - 12/2016
3	XenobioticsIBA 01/2018 - 10/2002
3	Messenger RNA (mRNA)IBA 11/2015 - 10/2006
3	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 06/2015 - 11/2007
3	Fluorouracil (Carac)FDA LinkGeneric 01/2015 - 05/2008
3	Cytochrome P-450 CYP3AIBA 09/2010 - 08/2005
3	Cytochrome P-450 CYP2D6 (CYP2D6)IBA 11/2007 - 10/2006
2	Progesterone Receptors (Progesterone Receptor)IBA 01/2021 - 01/2020
2	CholesterolIBA 01/2020 - 01/2017
2	Tamoxifen FDA LinkGeneric 03/2018 - 11/2007
2	Estrogens (Estrogen)FDA Link 03/2018 - 01/2016
2	Interleukin-6 (Interleukin 6)IBA 01/2018 - 01/2016
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2018 - 03/2013
2	Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)IBA 12/2015 - 05/2008
2	efavirenz (Sustiva)FDA Link 07/2014 - 09/2010
2	DNA (Deoxyribonucleic Acid)IBA 09/2013 - 03/2008
2	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 03/2013 - 01/2013
2	CationsIBA 12/2011 - 10/2009
2	Cytochrome P-450 CYP2C19IBA 11/2007 - 07/2007
2	thiopurine methyltransferase (thiopurine S-methyltransferase)IBA 03/2005 - 08/2002
2	Mercaptopurine (6 Mercaptopurine)FDA LinkGeneric 03/2005 - 08/2002
2	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2003 - 10/2002
1	Cytochrome P-450 CYP1A1 (CYP1A1)IBA 12/2020
1	Transforming Growth Factor beta (TGF-beta)IBA 01/2020
1	CytochromesIBA 01/2020
1	Heme-Binding ProteinsIBA 01/2020
1	Monoclonal AntibodiesIBA 01/2019
1	Estrogen ReceptorsIBA 03/2018
1	Bile Acids and Salts (Bile Acids)IBA 01/2018
1	Constitutive Androstane ReceptorIBA 01/2018
1	DefensinsIBA 01/2018
1	Triglycerides (Triacylglycerol)IBA 01/2018
1	Glucuronosyltransferase (UDP Glucuronosyltransferase)IBA 01/2018
1	UridineIBA 01/2018
1	IronIBA 01/2017
1	Heme (Haem)IBA 01/2017
1	Progesterone FDA LinkGeneric 01/2017
1	SteroidsIBA 01/2017
1	Cytochrome P-450 CYP2E1 (CYP2E1)IBA 12/2016
1	Sulfates (Sulfates, Inorganic)IBA 01/2016
1	Steryl-Sulfatase (Steroid Sulfatase)IBA 01/2016
1	Biomarkers (Surrogate Marker)IBA 11/2015
1	Metalloproteases (Metalloproteinases)IBA 11/2015
1	pirinixic acidIBA 06/2015
1	Cytochrome P-450 CYP2C9IBA 06/2015
1	Protein Isoforms (Isoforms)IBA 01/2015
1	Sterol Regulatory Element Binding ProteinsIBA 01/2015
1	Capecitabine (Xeloda)FDA Link 04/2014
1	NucleosidesIBA 05/2013
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 03/2013
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2013
1	Pantoprazole (Protonix)FDA LinkGeneric 01/2011
1	ChromatinIBA 01/2011
1	LactonesIBA 01/2011
1	Omeprazole (Prilosec)FDA LinkGeneric 01/2011

Therapy/Procedure

4	Therapeutics 01/2020 - 08/2002
4	Drug Therapy (Chemotherapy) 11/2015 - 03/2005
2	Aftercare (After-Treatment) 07/2006 - 03/2005
1	Ligation 11/2015