Martin E Young Selected Research

Infarction (Infarctions)

11/2023	β-hydroxybutyrate administered at reperfusion reduces infarct size and preserves cardiac function by improving mitochondrial function through autophagy in male mice.
1/2022	Activation of Autophagic Flux Maintains Mitochondrial Homeostasis during Cardiac Ischemia/Reperfusion Injury.
8/2010	The myocardial contractile response to physiological stress improves with high saturated fat feeding in heart failure.
11/2006	Dissociation between gene and protein expression of metabolic enzymes in a rodent model of heart failure.
10/2006	Chronic treatment with trimetazidine reduces the upregulation of atrial natriuretic peptide in heart failure.
5/2006	Effects of chronic activation of peroxisome proliferator-activated receptor-alpha or high-fat feeding in a rat infarct model of heart failure.

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Martin E Young Research Topics

Disease

19	Heart Failure 01/2021 - 01/2002
12	Hypertrophy 01/2022 - 04/2002
10	Obesity 05/2022 - 09/2007
8	Insulin Resistance 07/2023 - 08/2005
7	Cardiomegaly (Heart Hypertrophy) 07/2015 - 07/2004
6	Infarction (Infarctions) 11/2023 - 05/2006
6	Ischemia 01/2022 - 10/2006
6	Cardiomyopathies (Cardiomyopathy) 01/2022 - 10/2006
5	Hypoxia (Hypoxemia) 11/2007 - 02/2004
4	Hypertension (High Blood Pressure) 03/2024 - 12/2006
4	Inflammation (Inflammations) 05/2022 - 12/2015
4	Body Weight (Weight, Body) 05/2022 - 04/2014
4	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2022 - 02/2002
4	Diabetes Mellitus 01/2021 - 07/2008
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 08/2023 - 01/2020
3	Heart Diseases (Heart Disease) 01/2022 - 08/2002
3	Fibrosis (Cirrhosis) 01/2022 - 12/2015
3	Cardiovascular Diseases (Cardiovascular Disease) 11/2021 - 07/2008
3	Left Ventricular Dysfunction 01/2020 - 05/2006
3	Neoplasms (Cancer) 07/2013 - 07/2012
3	Dyslipidemias (Dyslipidemia) 07/2008 - 08/2005
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 06/2017
2	Myocardial Infarction 01/2022 - 11/2006
2	Reperfusion Injury 01/2022 - 06/2014
2	Chronic Disease (Chronic Diseases) 01/2021 - 10/2020
2	Weight Loss (Weight Reduction) 01/2021 - 01/2018
2	Diabetes Complications 01/2021 - 10/2020
2	Cardiotoxicity 07/2013 - 07/2013
2	Arthrogryposis renal dysfunction cholestasis syndrome 07/2008 - 06/2006
2	Type 2 Diabetes Mellitus (MODY) 12/2007 - 08/2005
2	Ventricular Remodeling 12/2006 - 06/2005
2	Atrophy 04/2006 - 04/2002
1	Acromegaly 01/2022
1	Autoimmune Diseases (Autoimmune Disease) 01/2022
1	Glucose Intolerance 01/2020
1	Hyperlipidemias (Hyperlipidemia) 01/2020

Drug/Important Bio-Agent (IBA)

22	Fatty Acids (Saturated Fatty Acids)IBA 01/2018 - 08/2002
16	Proteins (Proteins, Gene)FDA Link 01/2021 - 04/2002
14	Glucose (Dextrose)FDA LinkGeneric 07/2023 - 04/2004
10	Triglycerides (Triacylglycerol)IBA 07/2023 - 05/2006
10	Messenger RNA (mRNA)IBA 01/2022 - 02/2004
9	EnzymesIBA 12/2015 - 04/2004
8	LipidsIBA 05/2022 - 08/2002
7	PPAR alphaIBA 04/2007 - 11/2004
6	Insulin (Novolin)FDA Link 05/2022 - 06/2006
5	salicylhydroxamic acid (SHAM)IBA 03/2017 - 05/2006
5	Atrial Natriuretic Factor (ANF)IBA 04/2011 - 10/2006
4	Acyl-CoA Dehydrogenase (Medium-Chain Acyl-Coenzyme A Dehydrogenase)IBA 07/2008 - 05/2006
3	GlycogenIBA 01/2020 - 12/2007
3	TransferasesIBA 01/2020 - 06/2005
3	Streptozocin (Streptozotocin)FDA Link 01/2020 - 02/2002
3	AMP-Activated Protein KinasesIBA 07/2015 - 07/2004
3	Lipase (Acid Lipase)FDA Link 08/2013 - 05/2013
3	Protein Isoforms (Isoforms)IBA 11/2007 - 06/2006
3	Fenofibrate (CiL)FDA LinkGeneric 04/2007 - 05/2006
2	Mitochondrial DNA (mtDNA)IBA 11/2023 - 01/2022
2	Syndecan-4IBA 08/2023 - 07/2023
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 05/2022 - 08/2007
2	Peptides (Polypeptides)IBA 05/2022 - 01/2022
2	Adenosine Triphosphate (ATP)IBA 01/2022 - 07/2012
2	Biomarkers (Surrogate Marker)IBA 11/2021 - 01/2002
2	Glucagon (Glukagon)FDA Link 01/2021 - 01/2018
2	fibroblast growth factor 21IBA 01/2021 - 01/2018
2	IUB288IBA 01/2021 - 01/2018
2	KetonesIBA 01/2020 - 06/2017
2	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2020 - 05/2006
2	LigandsIBA 01/2020 - 02/2007
2	CarbohydratesIBA 01/2018 - 12/2006
2	Ethanol (Ethyl Alcohol)IBA 06/2015 - 01/2013
2	Proteasome Endopeptidase Complex (Proteasome)IBA 06/2014 - 04/2006
2	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 08/2013 - 11/2006
2	Doxorubicin (Adriamycin)FDA LinkGeneric 07/2013 - 07/2013
2	Dietary Fats (Dietary Fat)IBA 08/2010 - 12/2006
2	Oleic Acid (Oleate)IBA 07/2008 - 06/2006
2	Nonesterified Fatty Acids (NEFA)IBA 04/2007 - 04/2004
2	Carnitine (L-Carnitine)FDA LinkGeneric 01/2007 - 06/2005
2	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 01/2007 - 06/2005
1	Saline SolutionIBA 11/2023
1	Indicators and Reagents (Reagents)IBA 07/2023
1	LeptinIBA 05/2022
1	Beclin-1IBA 01/2022
1	Insulin-Like PeptidesIBA 01/2022
1	Growth Hormone (Somatotropin)IBA 01/2022
1	Glucagon Receptors (Glucagon Receptor)IBA 01/2021
1	Branched-Chain Amino AcidsIBA 01/2021
1	succinyl-coenzyme A (succinyl-CoA)IBA 01/2020
1	hexosaminidase CIBA 01/2020
1	mitoquinoneIBA 01/2020
1	empagliflozinIBA 01/2020
1	AntioxidantsIBA 01/2020
1	Blood Glucose (Blood Sugar)IBA 01/2020
1	CalciumIBA 01/2020
1	Coenzyme A (CoA)IBA 01/2020
1	Hydroxybutyrate Dehydrogenase (3 Hydroxybutyrate Dehydrogenase)IBA 01/2020
1	IonophoresIBA 01/2020

Therapy/Procedure

4	Therapeutics 01/2022 - 01/2020
3	Ligation 07/2008 - 11/2006
2	Chronotherapy 03/2024 - 01/2021
1	Pain Management 03/2024
1	Oral Administration 01/2020