Mitsuaki Yamazaki Selected Research

((3- methoxythiophen- 2- yl)methyl)((2- (9- (pyridin- 2- yl)- 6- oxaspiro(4.5)decan- 9- yl)ethyl))amine

1/2021	Further investigation of the rapid-onset and short-duration action of the G protein-biased μ-ligand oliceridine.
1/2017	Usefulness for the combination of G-protein- and β-arrestin-biased ligands of μ-opioid receptors: Prevention of antinociceptive tolerance.

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Mitsuaki Yamazaki Research Topics

Disease

12	Neuralgia (Stump Neuralgia) 01/2023 - 01/2004
12	Pain (Aches) 01/2022 - 07/2004
7	Hyperalgesia 01/2021 - 07/2004
6	Chronic Pain 01/2023 - 04/2004
5	Sepsis (Septicemia) 01/2018 - 05/2012
4	Inflammation (Inflammations) 01/2018 - 04/2014
2	Hemorrhage 08/2022 - 07/2011
2	Glucose Intolerance 08/2019 - 11/2016
2	Postoperative Pain 01/2018 - 11/2009
2	Neoplasms (Cancer) 08/2017 - 07/2014
2	Body Weight (Weight, Body) 11/2016 - 07/2014
2	Pneumonia (Pneumonitis) 04/2014 - 07/2012
1	Heart Failure 01/2023
1	Ischemic Stroke 01/2023
1	Retrograde Amnesia 12/2022
1	Amnesia (Dissociative Amnesia) 12/2022
1	Thrombosis (Thrombus) 08/2022
1	Sleep Wake Disorders 01/2022
1	Breakthrough Pain 01/2021
1	Hypotension (Low Blood Pressure) 01/2021
1	Aortic Valve Stenosis (Aortic Stenosis) 01/2021
1	Postherpetic Neuralgia 06/2020
1	Tetanus 10/2019
1	Sleep Initiation and Maintenance Disorders (Insomnia) 08/2019
1	Lung Neoplasms (Lung Cancer) 01/2018
1	Sepsis-Associated Encephalopathy 01/2018
1	Intervertebral Disc Degeneration 12/2017
1	Peripheral Nervous System Diseases (PNS Diseases) 08/2017
1	Diabetes Mellitus 08/2017
1	Dyslipidemias (Dyslipidemia) 08/2017
1	Lung Injury 12/2016
1	Insulin Resistance 11/2016
1	Type 2 Diabetes Mellitus (MODY) 11/2016
1	Acute Kidney Injury (Acute Renal Failure) 03/2016
1	Muscular Atrophy (Muscle Atrophy) 07/2014
1	Fatigue 07/2014

Drug/Important Bio-Agent (IBA)

3	Morphine (MS Contin)FDA LinkGeneric 12/2004 - 01/2004
2	Dynorphins (Dynorphin)IBA 01/2023 - 02/2010
2	Antidepressive Agents (Antidepressants)IBA 01/2022 - 07/2008
2	suvorexantIBA 01/2022 - 11/2016
2	((3- methoxythiophen- 2- yl)methyl)((2- (9- (pyridin- 2- yl)- 6- oxaspiro(4.5)decan- 9- yl)ethyl))amineIBA 01/2021 - 01/2017
2	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2021 - 07/2008
2	Opioid Receptors (Opioid Receptor)IBA 01/2021 - 01/2017
2	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)IBA 01/2020 - 07/2008
2	Anesthetics (Anesthetic Agents)IBA 10/2019 - 04/2008
2	OrexinsIBA 08/2019 - 11/2016
2	Fentanyl (Sublimaze)FDA LinkGeneric 01/2017 - 11/2009
2	CytokinesIBA 12/2016 - 04/2014
2	Messenger RNA (mRNA)IBA 11/2016 - 07/2014
2	Serotonin (5 Hydroxytryptamine)IBA 12/2013 - 07/2008
2	Freund's AdjuvantIBA 02/2010 - 04/2006
2	Phorbol 12,13-DibutyrateIBA 12/2004 - 07/2004
2	Protein Kinase CIBA 12/2004 - 07/2004
1	norbinaltorphimineIBA 01/2023
1	omega-Chloroacetophenone (Mace)IBA 01/2023
1	kappa Opioid Receptors (kappa Opioid Receptor)IBA 01/2023
1	LigandsIBA 01/2023
1	Sevoflurane (Ultane)FDA LinkGeneric 12/2022
1	Vitamin K FDA Link 08/2022
1	Warfarin (Coumadin)FDA LinkGeneric 08/2022
1	Mirtazapine (Rexer)FDA LinkGeneric 01/2022
1	GTP-Binding Proteins (G-Protein)IBA 01/2021
1	Dopamine (Intropin)FDA LinkGeneric 01/2021
1	remimazolamIBA 01/2021
1	volinanserinIBA 01/2020
1	5-HT2A Serotonin Receptor (5 HT2A Receptor)IBA 01/2020
1	Amitriptyline (Elavil)FDA LinkGeneric 01/2020
1	Orexin Receptor AntagonistsIBA 08/2019
1	Streptozocin (Streptozotocin)FDA Link 08/2019
1	CCR10 ReceptorsIBA 01/2018
1	G-Protein-Coupled Receptor Kinase 2IBA 01/2018
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2018
1	3- (5- (4- (cyclopentyloxy)- 2- hydroxybenzoyl)- 2- ((3- hydroxy- 1,2- benzisoxazol- 6- yl)methoxy)phenyl)propionic acidIBA 12/2017
1	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 12/2017
1	Clopidogrel (Plavix)FDA Link 08/2017
1	Paclitaxel (Taxol)FDA LinkGeneric 08/2017
1	Histamine (Histamine Dihydrochloride)FDA Link 12/2016
1	Triglycerides (Triacylglycerol)IBA 11/2016
1	Glucagon (Glukagon)FDA Link 11/2016
1	Insulin (Novolin)FDA Link 11/2016
1	MicroRNAs (MicroRNA)IBA 01/2016
1	Cisplatin (Platino)FDA LinkGeneric 07/2014
1	Proteins (Proteins, Gene)FDA Link 07/2014
1	MyostatinIBA 07/2014
1	PlatinumIBA 07/2014
1	Histone Deacetylases (Histone Deacetylase)IBA 04/2014
1	Histone Deacetylase InhibitorsIBA 04/2014

Therapy/Procedure

17	Ligation 01/2023 - 01/2004
5	Punctures 01/2018 - 10/2007
2	Anesthesia 12/2022 - 04/2008
2	Spinal Injections 02/2010 - 07/2004
1	General Anesthesia 12/2022
1	Heart-Assist Devices 08/2022
1	Analgesia 06/2020
1	Thoracotomy 01/2018
1	Knee Replacement Arthroplasty (Total Knee Replacement) 01/2018
1	Oral Administration 12/2017
1	Off-Pump Coronary Artery Bypass (Coronary Artery Bypass, Off Pump) 03/2016
1	Drug Therapy (Chemotherapy) 07/2014
1	Diet Therapy (Therapy, Diet) 07/2014