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Kenzo Yamanaka Selected Research

Neoplasms (Cancer)

2/2021Sustained high expression of NRF2 and its target genes induces dysregulation of cellular proliferation and apoptosis is associated with arsenite-induced malignant transformation of human bronchial epithelial cells.
9/2020Long-term arsenite exposure decreases autophagy by increased release of Nrf2 in transformed human keratinocytes.
12/2015Hypermethylation of the Keap1 gene inactivates its function, promotes Nrf2 nuclear accumulation, and is involved in arsenite-induced human keratinocyte transformation.
12/2015Continuous activation of Nrf2 and its target antioxidant enzymes leads to arsenite-induced malignant transformation of human bronchial epithelial cells.
4/2015Proposal for novel metabolic pathway of highly toxic dimethylated arsenics accompanied by enzymatic sulfuration, desulfuration and oxidation.
6/2009Methylamine dichloramine may play a role in the process of colorectal disease through architectural and oxidative changes in crypts in mice.
4/2009Dimethylarsine likely acts as a mouse-pulmonary tumor initiator via the production of dimethylarsine radical and/or its peroxy radical.
4/2009Dimethylarsine likely acts as a mouse-pulmonary tumor initiator via the production of dimethylarsine radical and/or its peroxy radical.
12/2005Specific induction of oxidative stress in terminal bronchiolar Clara cells during dimethylarsenic-induced lung tumor promoting process in mice.
8/2005The role of trivalent dimethylated arsenic in dimethylarsinic acid-promoted skin and lung tumorigenesis in mice: tumor-promoting action through the induction of oxidative stress.
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Kenzo Yamanaka Research Topics

Disease

12Neoplasms (Cancer)
02/2021 - 08/2004
9Carcinogenesis
02/2021 - 01/2002
4Skin Neoplasms (Skin Cancer)
09/2020 - 10/2004
4Poisoning
01/2015 - 06/2008
3Lung Neoplasms (Lung Cancer)
12/2020 - 12/2015
2Hemolysis
04/2014 - 06/2009
1Leukemia
12/2021
1Insulin Resistance
07/2019
1Type 2 Diabetes Mellitus (MODY)
07/2019
1Glaucoma
01/2016
1Hemoglobinuria
01/2015
1Colitis
06/2009
1Brain Diseases (Brain Disorder)
06/2008
1Neurologic Manifestations (Neurological Manifestations)
06/2008
1Sneezing
11/2007
1Vomiting
11/2007
1Keratosis
10/2004

Drug/Important Bio-Agent (IBA)

8ArsenicIBA
02/2021 - 07/2003
5arsineIBA
01/2015 - 04/2009
4arseniteIBA
09/2020 - 01/2002
4Cacodylic Acid (Cacodylate)IBA
04/2015 - 08/2004
2CarcinogensIBA
05/2020 - 08/2005
2DNA AdductsIBA
04/2009 - 04/2009
28-Hydroxy-2'-DeoxyguanosineIBA
08/2005 - 10/2004
1Sulfides (Thioethers)IBA
12/2021
1Vitamin K 3 (Menadione)FDA Link
12/2021
1thiazolyl blueIBA
12/2021
1NF-E2-Related Factor 2IBA
12/2020
1Glucose (Dextrose)FDA LinkGeneric
07/2019
1Fibroins (Fibroin)IBA
07/2019
1Peptides (Polypeptides)IBA
07/2019
1Transcription Factors (Transcription Factor)IBA
12/2015
1AntioxidantsIBA
12/2015
1Reactive Oxygen Species (Oxygen Radicals)IBA
04/2015
1dimethylarsinous acidIBA
04/2015
1hydroxide ionIBA
04/2015
1Biomarkers (Surrogate Marker)IBA
01/2015
1Indicators and Reagents (Reagents)IBA
04/2014
1Arsenicals (Arsenic Compounds)IBA
01/2011
1ChloraminesIBA
06/2009
1Hemoglobins (Hemoglobin)IBA
06/2009
1methylamine dichloramineIBA
06/2009
1methylamine (methylammonium)IBA
06/2009
1SuspensionsIBA
06/2009
1TinIBA
06/2008
1diphenylarsinic acidIBA
11/2007
1Drinking WaterIBA
11/2007
14-hydroxy-2-nonenal (4-hydroxynonenal)IBA
12/2005
1epigallocatechin gallate (epigallocatechin-3-gallate)IBA
08/2005
1dimethylarsineIBA
08/2004
1Oxygen (Dioxygen)IBA
08/2004
1Free RadicalsIBA
08/2004
1PeroxidesIBA
08/2004

Therapy/Procedure

2Drug Therapy (Chemotherapy)
12/2015 - 12/2015
2Oral Administration
04/2009 - 04/2009
1Telescopes
01/2016