Osamu Yamaguchi Selected Research

Deamino Arginine Vasopressin (Desmopressin)

1/2021	Achieving clinically meaningful quality of life benefits in nocturia takes time: Results from a long-term, multicenter phase 3 study of desmopressin in Japanese patients.
1/2020	Efficacy and safety of 25 and 50 μg desmopressin orally disintegrating tablets in Japanese patients with nocturia due to nocturnal polyuria: Results from two phase 3 studies of a multicenter randomized double-blind placebo-controlled parallel-group development program.
3/2013	Gender difference in efficacy and dose response in Japanese patients with nocturia treated with four different doses of desmopressin orally disintegrating tablet in a randomized, placebo-controlled trial.

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Osamu Yamaguchi Research Topics

Disease

29	Overactive Urinary Bladder (Overactive Bladder) 11/2022 - 05/2002
25	Heart Failure 02/2024 - 06/2004
15	Ischemia 01/2019 - 02/2003
10	Cardiomegaly (Heart Hypertrophy) 06/2015 - 01/2002
9	Urinary Bladder Neck Obstruction (Bladder Neck Obstruction) 03/2016 - 08/2003
8	Nocturia 01/2021 - 09/2007
7	Neoplasms (Cancer) 04/2023 - 01/2002
7	Inflammation (Inflammations) 01/2023 - 05/2012
7	Hypertrophy 04/2013 - 01/2002
6	Infections 01/2017 - 01/2002
5	Atherosclerosis 01/2023 - 01/2012
5	Coronary Artery Disease (Coronary Atherosclerosis) 03/2022 - 04/2009
5	Lower Urinary Tract Symptoms 01/2021 - 07/2011
5	Fibrosis (Cirrhosis) 06/2020 - 05/2005
4	Thrombosis (Thrombus) 04/2023 - 12/2020
4	Aneurysm (Aneurysms) 01/2023 - 11/2007
4	Atrial Fibrillation 01/2023 - 10/2015
4	Myocardial Infarction 02/2017 - 01/2007
4	Constipation 09/2016 - 05/2003
3	Tachycardia (Tachyarrhythmias) 10/2023 - 05/2002
3	Myocardial Ischemia (Ischemic Heart Diseases) 01/2023 - 01/2019
3	Respiratory Insufficiency (Respiratory Failure) 12/2021 - 01/2013
3	Hemorrhage 02/2017 - 01/2007
3	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 05/2012 - 10/2004
3	Carcinoma (Carcinomatosis) 09/2011 - 08/2006
3	Reinfection 01/2011 - 07/2007
2	Frailty 04/2024 - 04/2024
2	Cardiac Arrhythmias (Arrythmia) 10/2023 - 05/2009
2	Myocarditis (Carditis) 10/2023 - 05/2012
2	Shock 09/2023 - 03/2017
2	Rupture 05/2023 - 01/2023
2	Abdominal Aortic Aneurysm 01/2023 - 10/2019
2	Atherosclerotic Plaque (Atheroma) 01/2023 - 10/2019
2	Underactive Urinary Bladder 11/2022 - 01/2022
2	Dyspnea (Shortness of Breath) 12/2021 - 03/2017
2	Cardiomyopathies (Cardiomyopathy) 12/2021 - 05/2012
2	Pathologic Constriction (Stenosis) 01/2021 - 10/2020
2	Polyuria 01/2020 - 09/2013
2	Infarction (Infarctions) 01/2019 - 12/2016
2	Pulmonary Hypertension 07/2018 - 01/2017
2	Left Ventricular Dysfunction 03/2017 - 01/2007
2	Cardiogenic Shock 03/2017 - 01/2007

Drug/Important Bio-Agent (IBA)

13	mirabegronIBA 01/2021 - 01/2013
10	Muscarinic AntagonistsIBA 01/2020 - 05/2003
7	CytokinesIBA 01/2020 - 01/2011
7	MAP Kinase Kinase Kinase 5IBA 01/2008 - 01/2002
6	Tamsulosin (Flomax)FDA LinkGeneric 01/2021 - 04/2011
6	Messenger RNA (mRNA)IBA 01/2020 - 03/2002
6	Proteins (Proteins, Gene)FDA Link 01/2018 - 05/2006
6	Phosphotransferases (Kinase)IBA 04/2013 - 02/2003
4	Cytidine Triphosphate (CTP)IBA 03/2022 - 01/2020
4	Oxygen (Dioxygen)IBA 12/2020 - 08/2008
4	silodosin FDA Link 01/2016 - 09/2013
4	Solifenacin Succinate FDA Link 10/2015 - 09/2007
4	Biomarkers (Surrogate Marker)IBA 10/2014 - 09/2011
4	propiverineIBA 06/2014 - 09/2007
4	Angiotensin IIIBA 11/2013 - 01/2002
4	imidafenacinIBA 09/2013 - 09/2008
4	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2005 - 01/2002
4	Phenylephrine (Neo-Synephrine)FDA LinkGeneric 02/2005 - 01/2002
4	NF-kappa B (NF-kB)IBA 02/2005 - 01/2002
3	Adenosine Triphosphate (ATP)IBA 10/2023 - 11/2006
3	CollagenIBA 01/2023 - 06/2008
3	AnticoagulantsIBA 01/2022 - 11/2007
3	TabletsIBA 01/2021 - 03/2013
3	Deamino Arginine Vasopressin (Desmopressin)FDA LinkGeneric 01/2021 - 03/2013
3	Toll-Like Receptor 9IBA 06/2019 - 12/2016
3	DNA (Deoxyribonucleic Acid)IBA 06/2019 - 01/2011
3	Mitochondrial DNA (mtDNA)IBA 01/2019 - 05/2012
3	Adrenergic Receptors (Adrenergic Receptor)IBA 01/2017 - 05/2015
3	InterferonsIBA 01/2017 - 01/2011
3	salicylhydroxamic acid (SHAM)IBA 12/2016 - 03/2011
3	oxybutynin (Tavor)FDA LinkGeneric 09/2016 - 06/2014
3	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 01/2015 - 01/2013
3	Tadalafil (Cialis)FDA Link 06/2014 - 01/2013
3	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 06/2014 - 01/2009
3	Atorvastatin (Lipitor)FDA Link 06/2013 - 04/2009
3	CalciumIBA 04/2013 - 01/2003
3	CalpainIBA 10/2012 - 07/2007
3	AntioxidantsIBA 07/2012 - 03/2002
2	Phenobarbital (Luminal)FDA Link 01/2023 - 06/2014
2	Diphosphonates (Bisphosphonates)IBA 07/2021 - 01/2017
2	GlucocorticoidsIBA 07/2021 - 01/2017
2	Vasodilator Agents (Vasodilators)IBA 12/2020 - 07/2018
2	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 06/2020 - 03/2012
2	GadoliniumIBA 06/2020 - 01/2020
2	Phosphates (Orthophosphate)IBA 06/2019 - 08/2006
2	Hemoglobins (Hemoglobin)IBA 01/2019 - 08/2008

Therapy/Procedure

27	Therapeutics 12/2021 - 05/2002
4	Stents 01/2023 - 01/2007
4	Catheter Ablation 01/2023 - 10/2015
3	Percutaneous Coronary Intervention 09/2023 - 01/2022
3	Heart-Assist Devices 01/2022 - 07/2018
3	Artificial Respiration (Mechanical Ventilation) 03/2018 - 01/2013
3	Aftercare (After-Treatment) 03/2017 - 01/2005
3	Transplantation 01/2016 - 10/2008
3	Denervation 01/2016 - 01/2014
3	Kidney Transplantation 01/2011 - 03/2002
2	Catheters 01/2019 - 11/2009
2	Cardiopulmonary Bypass (Heart-Lung Bypass) 01/2018 - 01/2013