Hirohito Yamaguchi Selected Research

Neoplasm Metastasis (Metastasis)

3/2024	Unlocking c-MET: A comprehensive journey into targeted therapies for breast cancer.
1/2020	A Potential Role of YAP/TAZ in the Interplay Between Metastasis and Metabolic Alterations.
12/2017	Pneumatically Actuated Soft Micromold Device for Fabricating Collagen and Matrigel Microparticles.
7/2014	Regulation and Role of EZH2 in Cancer.
8/2011	Dual targeting of tumor angiogenesis and chemotherapy by endostatin-cytosine deaminase-uracil phosphoribosyltransferase.
8/2009	EPOX inhibits angiogenesis by degradation of Mcl-1 through ERK inactivation.
10/2008	Interferon-inducible protein IFIXalpha inhibits cell invasion by upregulating the metastasis suppressor maspin.
11/2007	Anoikis, initiated by Mcl-1 degradation and Bim induction, is deregulated during oncogenesis.

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Hirohito Yamaguchi Research Topics

Disease

41	Neoplasms (Cancer) 01/2024 - 01/2002
21	Breast Neoplasms (Breast Cancer) 03/2024 - 01/2002
8	Neoplasm Metastasis (Metastasis) 03/2024 - 11/2007
8	Triple Negative Breast Neoplasms 01/2022 - 01/2015
4	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 03/2024 - 02/2013
4	Colorectal Neoplasms (Colorectal Cancer) 01/2019 - 12/2015
4	Lung Neoplasms (Lung Cancer) 01/2019 - 08/2011
3	Hepatocellular Carcinoma (Hepatoma) 01/2019 - 01/2015
3	Colonic Neoplasms (Colon Cancer) 10/2004 - 04/2003
2	Carcinogenesis 08/2016 - 10/2012
2	Ovarian Neoplasms (Ovarian Cancer) 02/2016 - 08/2009
1	Infections 10/2023
1	Liver Neoplasms (Liver Cancer) 01/2019
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2015
1	Adenocarcinoma 01/2015
1	Hyperammonemia 01/2015

Drug/Important Bio-Agent (IBA)

11	Proteins (Proteins, Gene)FDA Link 10/2023 - 01/2003
7	Poly(ADP-ribose) Polymerase InhibitorsIBA 10/2022 - 02/2016
5	LigandsIBA 03/2024 - 12/2016
4	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 10/2022 - 02/2016
4	Phosphotransferases (Kinase)IBA 10/2022 - 01/2012
4	Biomarkers (Surrogate Marker)IBA 10/2022 - 01/2015
4	Immune Checkpoint InhibitorsIBA 01/2022 - 07/2017
4	Tyrosine Kinase InhibitorsIBA 01/2019 - 02/2013
4	ErbB Receptors (EGF Receptor)IBA 12/2018 - 02/2013
3	Programmed Cell Death 1 ReceptorIBA 01/2022 - 12/2018
3	Cetuximab (Erbitux)FDA Link 01/2019 - 12/2015
3	Epidermal Growth Factor (EGF)IBA 12/2018 - 03/2014
3	Antineoplastic Agents (Antineoplastics)IBA 01/2015 - 09/2004
3	epothilone B (EPO906)IBA 10/2003 - 01/2002
2	capmatinibIBA 03/2024 - 01/2019
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 03/2024 - 01/2021
2	PlatinumIBA 10/2022 - 02/2013
2	AntibodiesIBA 01/2022 - 01/2019
2	Ribonucleases (Ribonuclease)IBA 01/2021 - 01/2019
2	B7-H1 AntigenIBA 01/2021 - 12/2018
2	olaparibIBA 01/2020 - 02/2016
2	human ERBB2 proteinIBA 11/2019 - 01/2016
2	Progesterone Receptors (Progesterone Receptor)IBA 11/2019 - 01/2016
2	Estrogen ReceptorsIBA 11/2019 - 01/2016
2	Monoclonal AntibodiesIBA 01/2018 - 01/2016
2	CytokinesIBA 12/2016 - 03/2012
2	DNA (Deoxyribonucleic Acid)IBA 02/2016 - 03/2014
2	Transcription Factors (Transcription Factor)IBA 07/2014 - 08/2009
2	Bevacizumab (Avastin)FDA Link 10/2012 - 08/2011
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2012 - 08/2011
2	Paclitaxel (Taxol)FDA LinkGeneric 11/2011 - 01/2002
2	Docetaxel (Taxotere)FDA Link 09/2005 - 10/2003
2	Histone Deacetylase InhibitorsIBA 09/2005 - 10/2003
2	Trastuzumab (Herceptin)FDA Link 09/2005 - 10/2003
2	ThapsigarginIBA 10/2004 - 04/2003
2	Caspase 3 (Caspase-3)IBA 10/2004 - 04/2003
1	Proto-Oncogene Proteins c-metIBA 03/2024
1	CrizotinibIBA 03/2024
1	cabozantinibIBA 03/2024
1	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 03/2024
1	tepotinibIBA 03/2024
1	ClaudinsIBA 01/2024
1	Positive Transcriptional Elongation Factor BIBA 10/2022
1	Irinotecan (Camptosar)FDA LinkGeneric 01/2022
1	Immunoconjugates (Immunoconjugate)IBA 01/2022
1	Topoisomerase I InhibitorsIBA 01/2022
1	Surface Antigens (Surface Antigen)IBA 01/2022
1	Hormones (Hormone)IBA 01/2021
1	SteroidsIBA 01/2021
1	RNA (Ribonucleic Acid)IBA 01/2021
1	Progesterone FDA LinkGeneric 01/2021
1	Estrogens (Estrogen)FDA Link 01/2021
1	Ephrin-A4 (Ephrin A4)IBA 01/2021
1	Therapeutic UsesIBA 10/2020
1	tyrosine receptor (receptor, tyrosine)IBA 10/2020
1	talazoparibIBA 01/2020
1	Tamoxifen FDA LinkGeneric 11/2019
1	Phenobarbital (Luminal)FDA Link 11/2019
1	Tyrosine (L-Tyrosine)FDA Link 01/2019
1	ARQ 197IBA 01/2019
1	Glycogen Synthase KinasesIBA 01/2019
1	TransferasesIBA 12/2018
1	Arginine (L-Arginine)FDA Link 01/2018
1	matrigelIBA 12/2017
1	CollagenIBA 12/2017
1	CurcuminIBA 12/2016
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2016
1	Histone MethyltransferasesIBA 08/2016
1	Histones (Histone)IBA 08/2016
1	ResveratrolIBA 03/2016
1	MK 2206IBA 03/2016
1	Pyruvic Acid (Pyruvate)IBA 01/2016
1	EnzymesIBA 01/2016
1	Pyruvate KinaseIBA 01/2016
1	PhosphoenolpyruvateIBA 01/2016
1	Protein Isoforms (Isoforms)IBA 01/2016
1	carglumic acid FDA Link 01/2015
1	MicroRNAs (MicroRNA)IBA 07/2014
1	Untranslated RNA (Noncoding RNA)IBA 07/2014
1	Enhancer of Zeste Homolog 2 ProteinIBA 07/2014
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 03/2014

Therapy/Procedure

12	Therapeutics 03/2024 - 08/2009
4	Drug Therapy (Chemotherapy) 01/2015 - 08/2011
1	Immunotherapy 01/2024