Kazuhiko Yamada Selected Research

Immune Checkpoint Inhibitors

12/2021	Current status of immune checkpoint inhibitor therapy for advanced esophageal squamous cell carcinoma.
1/2021	Comparative incidence of immune-related adverse events and hyperprogressive disease in patients with non-small cell lung cancer receiving immune checkpoint inhibitors with and without chemotherapy.
1/2021	E7386, a Selective Inhibitor of the Interaction between β-Catenin and CBP, Exerts Antitumor Activity in Tumor Models with Activated Canonical Wnt Signaling.
1/2020	Predictive value of CD73 expression for the efficacy of immune checkpoint inhibitors in NSCLC.
12/2018	Immunomodulatory activity of lenvatinib contributes to antitumor activity in the Hepa1-6 hepatocellular carcinoma model.

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Kazuhiko Yamada Research Topics

Disease

53	Neoplasms (Cancer) 05/2024 - 08/2002
43	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2021 - 01/2008
18	Esophageal Squamous Cell Carcinoma 01/2024 - 05/2014
12	Disease Progression 01/2020 - 10/2012
10	Neoplasm Metastasis (Metastasis) 02/2022 - 05/2003
9	Stomach Neoplasms (Stomach Cancer) 02/2022 - 05/2003
8	Lung Neoplasms (Lung Cancer) 06/2019 - 07/2005
6	Proteinuria 11/2021 - 11/2009
6	Diarrhea 01/2021 - 05/2007
6	Reperfusion Injury 01/2020 - 11/2008
5	Body Weight (Weight, Body) 06/2017 - 02/2002
4	Diabetic Nephropathies (Diabetic Nephropathy) 01/2024 - 11/2017
4	Adenocarcinoma of Lung 08/2023 - 07/2005
4	Squamous Cell Carcinoma (Epidermoid Carcinoma) 08/2023 - 12/2003
4	Hemorrhage 06/2023 - 01/2006
4	Ischemia 01/2023 - 06/2010
4	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2023 - 11/2002
4	Esophageal Neoplasms (Esophageal Cancer) 12/2022 - 01/2019
4	Stomatitis 01/2020 - 10/2012
4	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 04/2018 - 03/2007
3	Hepatocellular Carcinoma (Hepatoma) 11/2023 - 02/2005
3	Pneumonia (Pneumonitis) 01/2021 - 05/2002
3	Nausea 02/2019 - 03/2012
3	Adenocarcinoma 01/2018 - 05/2014
3	Hyperglycemia 11/2017 - 11/2002
3	Exanthema (Rash) 01/2017 - 01/2010
3	Carcinoma (Carcinomatosis) 02/2013 - 07/2007
2	Constipation 05/2024 - 03/2013
2	Chronic Kidney Failure (Chronic Renal Failure) 05/2024 - 01/2023
2	Brain Death (Brain Dead) 03/2024 - 01/2022
2	Fistula 11/2023 - 04/2021
2	Lymphatic Metastasis 06/2023 - 06/2009
2	Nephrotic Syndrome (Syndrome, Nephrotic) 11/2021 - 01/2018
2	Anorexia 01/2020 - 03/2013
2	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2019 - 09/2003
2	Hypertension (High Blood Pressure) 11/2017 - 10/2012
2	Febrile Neutropenia 01/2016 - 04/2014
2	Lymphopenia (Lymphocytopenia) 04/2014 - 03/2012
2	Infections 02/2010 - 09/2003
2	Heart Failure 11/2008 - 04/2004
2	Cardiomyopathies (Cardiomyopathy) 05/2004 - 04/2004

Drug/Important Bio-Agent (IBA)

12	ErbB Receptors (EGF Receptor)IBA 01/2020 - 10/2012
9	PlatinumIBA 02/2021 - 07/2007
8	Cisplatin (Platino)FDA LinkGeneric 01/2021 - 05/2007
8	Carboplatin (JM8)FDA LinkGeneric 12/2018 - 01/2008
7	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 05/2002
7	Erlotinib Hydrochloride (CP 358,774)FDA Link 01/2020 - 03/2013
6	Peptide Hydrolases (Proteases)FDA Link 01/2024 - 01/2018
6	Kallikreins (Kallikrein)IBA 01/2024 - 01/2018
6	Docetaxel (Taxotere)FDA Link 01/2021 - 04/2008
6	Tyrosine Kinase InhibitorsIBA 01/2020 - 01/2017
6	Paclitaxel (Taxol)FDA LinkGeneric 11/2017 - 07/2007
5	Immune Checkpoint InhibitorsIBA 12/2021 - 12/2018
5	LigandsIBA 11/2021 - 03/2015
4	AfatinibIBA 01/2021 - 01/2017
4	Bevacizumab (Avastin)FDA Link 01/2021 - 10/2015
4	Gefitinib (Iressa)FDA Link 07/2018 - 03/2013
4	Pemetrexed (MTA)FDA Link 06/2018 - 05/2014
3	Carbon MonoxideIBA 01/2020 - 06/2010
3	lenvatinibIBA 01/2019 - 04/2011
3	Irinotecan (Camptosar)FDA LinkGeneric 01/2018 - 05/2007
3	Proteins (Proteins, Gene)FDA Link 01/2018 - 04/2014
2	Indocyanine Green (Cardio-Green)FDA LinkGeneric 06/2023 - 10/2022
2	Carcinoembryonic AntigenIBA 12/2022 - 05/2019
2	CateninsIBA 01/2022 - 01/2021
2	Serine Proteases (Serine Protease)IBA 09/2021 - 01/2021
2	Antineoplastic Agents (Antineoplastics)IBA 01/2021 - 07/2005
2	necitumumabIBA 06/2019 - 01/2019
2	Gemcitabine FDA Link 06/2019 - 01/2019
2	Tumor Biomarkers (Tumor Markers)IBA 05/2019 - 04/2009
2	Monoclonal AntibodiesIBA 03/2019 - 10/2015
2	Angiogenesis InhibitorsIBA 12/2018 - 10/2010
2	HLA Antigens (Human Leukocyte Antigens)IBA 12/2017 - 02/2004
2	motesanib diphosphateIBA 11/2017 - 10/2010
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2015 - 11/2009
2	AcidsIBA 04/2014 - 06/2008
2	Biomarkers (Surrogate Marker)IBA 01/2013 - 04/2011
2	FibrinIBA 02/2012 - 01/2006
2	Doxorubicin (Adriamycin)FDA LinkGeneric 05/2004 - 04/2004

Therapy/Procedure

31	Drug Therapy (Chemotherapy) 05/2024 - 02/2005
23	Therapeutics 11/2023 - 04/2004
12	Heterologous Transplantation (Xenotransplantation) 03/2024 - 05/2002
11	Transplantation 01/2023 - 11/2002
9	Esophagectomy 03/2022 - 12/2003
7	Neoadjuvant Therapy 01/2024 - 07/2007
7	Chemoradiotherapy 01/2024 - 03/2007
6	Gastrectomy 06/2023 - 05/2003
6	Aftercare (After-Treatment) 01/2021 - 11/2014
6	Lymph Node Excision (Lymph Node Dissection) 11/2014 - 01/2009
4	Islets of Langerhans Transplantation 01/2024 - 11/2002
4	Kidney Transplantation 01/2023 - 04/2014
3	Hepatectomy 02/2022 - 05/2003
2	Pancreatectomy 01/2023 - 11/2002
2	Thoracotomy 08/2022 - 11/2007
2	Immunotherapy 01/2022 - 01/2019
2	Cell Transplantation 01/2022 - 04/2004
2	Radiotherapy 01/2021 - 03/2007
2	Warm Ischemia 01/2020 - 06/2010
2	Intravenous Infusions 05/2010 - 04/2008
2	Hormone Replacement Therapy (Therapy, Hormone Replacement) 10/2004 - 01/2003