T L Yaksh Selected Research

N-Methylaspartate (NMDA)

3/2008	Spinal N-methyl-D-aspartate receptors and nociception-evoked release of primary afferent substance P.
10/2001	Pain models display differential sensitivity to Ca2+-permeable non-NMDA glutamate receptor antagonists.
8/2001	The acute antihyperalgesic action of nonsteroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1.
6/2001	An automated flinch detecting system for use in the formalin nociceptive bioassay.
1/2000	Characterization of spinal amino acid release and touch-evoked allodynia produced by spinal glycine or GABA(A) receptor antagonist.

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T L Yaksh Research Topics

Disease

16	Hyperalgesia 04/2024 - 01/2000
11	Pain (Aches) 04/2024 - 01/2000
5	Inflammation (Inflammations) 01/2016 - 10/2001
3	Hypersensitivity (Allergy) 04/2024 - 01/2012
2	Necrosis 02/2015 - 08/2010
2	Ischemia 10/2011 - 06/2000
2	Spinal Cord Ischemia 09/2006 - 06/2000
2	Neuralgia (Stump Neuralgia) 03/2001 - 01/2000
1	Substance-Related Disorders (Drug Abuse) 01/2017
1	Arthritis (Polyarthritis) 01/2016
1	Polyneuropathies (Polyneuropathy) 11/2015
1	Spinal Cord Injuries (Spinal Cord Injury) 01/2014
1	Muscle Spasticity (Spastic) 10/2011
1	Paraplegia (Spastic Paraplegia) 10/2011
1	AIDS-Related Complex (ARC) 10/2011
1	Hypertension (High Blood Pressure) 10/2001
1	Body Weight (Weight, Body) 06/2001
1	Hypothermia 06/2000

Drug/Important Bio-Agent (IBA)

5	Formaldehyde (Formol)FDA Link 01/2018 - 10/2001
5	CarrageenanIBA 02/2015 - 08/2001
5	N-Methylaspartate (NMDA)IBA 03/2008 - 01/2000
3	Prostaglandins EIBA 04/2024 - 08/2001
3	ProstaglandinsIBA 04/2024 - 01/2005
3	Gabapentin (Neurontin)FDA LinkGeneric 01/2016 - 03/2001
3	Etanercept (Enbrel)FDA Link 02/2015 - 08/2010
3	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 03/2008 - 01/2000
3	Substance PIBA 01/2005 - 09/2000
2	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 04/2024 - 08/2001
2	Toll-Like Receptor 4IBA 04/2024 - 08/2010
2	EnzymesIBA 04/2024 - 06/2008
2	KetorolacIBA 01/2016 - 08/2010
2	Analgesics (Analgesic Drugs)IBA 01/2014 - 08/2000
2	Dizocilpine Maleate (Dizocilpine)IBA 03/2008 - 06/2001
2	gamma-Aminobutyric Acid (GABA)IBA 09/2006 - 01/2000
2	Morphine (MS Contin)FDA LinkGeneric 06/2001 - 08/2000
1	LipoxygenasesIBA 04/2024
1	ML355IBA 04/2024
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 04/2024
1	ethyl 6- (N- (2- chloro- 4- fluorophenyl)sulfamoyl)cyclohex- 1- ene- 1- carboxylateIBA 01/2018
1	Peptides (Polypeptides)IBA 01/2017
1	Opioid Analgesics (Opioids)IBA 01/2017
1	Voltage-Gated Sodium ChannelsIBA 01/2017
1	Collagen Type II (Type II Collagen)IBA 01/2016
1	Glucose-6-Phosphate Isomerase (Phosphoglucose Isomerase)IBA 01/2016
1	6-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA 01/2016
1	Cisplatin (Platino)FDA LinkGeneric 11/2015
1	JNK Mitogen-Activated Protein KinasesIBA 02/2015
1	Tumor Necrosis Factor InhibitorsIBA 02/2015
1	pyrazolanthroneIBA 02/2015
1	Anesthetics (Anesthetic Agents)IBA 01/2014
1	Matrix Metalloproteinase InhibitorsIBA 01/2012
1	N- (2(R)- 2- (hydroxamidocarbonylmethyl)- 4- methylpentanoyl)- L- tryptophan methylamideIBA 01/2012
1	Matrix Metalloproteinase 3 (Stromelysin 1)IBA 01/2012
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2012
1	Isoflurane FDA LinkGeneric 10/2011
1	IdazoxanIBA 10/2011
1	Yohimbine (Yocon)IBA 10/2011
1	Dihydrotachysterol (AT 10)IBA 10/2011
1	tizanidine (Zanaflex)FDA LinkGeneric 10/2011
1	atipamezoleIBA 10/2011
1	efaroxanIBA 10/2011
1	Minocycline (Cyclops)FDA LinkGeneric 08/2010
1	Pentoxifylline (Trental)FDA LinkGeneric 08/2010
1	Antisense OligonucleotidesIBA 06/2008
1	Messenger RNA (mRNA)IBA 06/2008
1	Protein Isoforms (Isoforms)IBA 06/2008
1	Phospholipases (Phospholipase)IBA 06/2008
1	AcidsIBA 03/2008
1	Dinoprostone (PGE2)FDA Link 06/2005
1	1-nitrohydroxyphenyl-N-benzoylalanine (GAL 1)IBA 06/2005
1	GalaninIBA 06/2005
1	EicosanoidsIBA 01/2005
1	Phospholipases A2 (Phospholipase A2)IBA 01/2005
1	Secretory Phospholipases A2IBA 01/2005
1	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 10/2001
1	Excitatory Amino Acid AntagonistsIBA 10/2001
1	cytisineIBA 10/2001
1	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 08/2001
1	IsoenzymesIBA 08/2001
1	Anticonvulsants (Antiepileptic Drugs)IBA 03/2001
1	A 17 (A-17)IBA 03/2001
1	Calcium Channels (Calcium Channel)IBA 03/2001
1	bisindolylmaleimide IIBA 09/2000
1	Protein Kinase CIBA 09/2000
1	GTP-Binding Proteins (G-Protein)IBA 09/2000
1	Choline (Choline Chloride)IBA 08/2000
1	Liposomes (Liposome)IBA 08/2000
1	Proteins (Proteins, Gene)FDA Link 06/2000
1	PotassiumIBA 06/2000
1	Amino Acids FDA Link 01/2000
1	StrychnineIBA 01/2000
1	Serine (L-Serine)FDA Link 01/2000
1	Glycine Receptors (Glycine Receptor)IBA 01/2000
1	Glutamic Acid (Glutamate)FDA Link 01/2000

Therapy/Procedure

5	Catheters 06/2005 - 06/2000
3	Ligation 06/2005 - 03/2001
1	Therapeutics 01/2017
1	Analgesia 01/2017
1	Spinal Injections 02/2015
1	Anesthesia 10/2011