Chuan-Rui Xu Selected Research

Camptothecin

10/2023	Improved anti-tumor activity of fluorinated camptothecin derivatives 9-fluorocamptothecin and 7-ethyl-9-fluorocamptothecin on hepatocellular carcinoma by targeting topoisomerase I.
12/2022	Anti-tumor effects and mechanism of a novel camptothecin derivative YCJ100.
1/2022	Design and synthesis of Aza-boeravinone derivatives as potential novel topoisomerase I inhibitors.

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Chuan-Rui Xu Research Topics

Disease

7	Neoplasms (Cancer) 10/2023 - 09/2014
5	Hepatocellular Carcinoma (Hepatoma) 10/2023 - 09/2014
1	Inflammation (Inflammations) 04/2020
1	Porcine Reproductive and Respiratory Syndrome (PRRS) 04/2020
1	Carcinogenesis 10/2015
1	Carcinoma (Carcinomatosis) 10/2015
1	Liver Neoplasms (Liver Cancer) 09/2014

Drug/Important Bio-Agent (IBA)

3	CamptothecinIBA 10/2023 - 01/2022
3	MicroRNAs (MicroRNA)IBA 12/2016 - 09/2014
2	Topotecan (Hycamtin)FDA LinkGeneric 10/2023 - 01/2022
2	Topoisomerase I InhibitorsIBA 01/2022 - 01/2022
2	Proteins (Proteins, Gene)FDA Link 04/2020 - 10/2015
1	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 10/2023
1	9 alpha,11 alpha,15 alpha- trihydroxy- 16- phenoxy- 17,18,19,20- tetranorprosta- 4,5,13- trienoic acid (TPT)IBA 10/2023
1	Type I DNA Topoisomerases (Topoisomerase I)IBA 10/2023
1	Irinotecan (Camptosar)FDA LinkGeneric 01/2021
1	Pattern Recognition ReceptorsIBA 04/2020
1	Mitogen-Activated Protein KinasesIBA 04/2020
1	CytokinesIBA 04/2020
1	GoldIBA 12/2016
1	Small Interfering RNA (siRNA)IBA 10/2015
1	LipofectamineIBA 10/2015

Therapy/Procedure

1	Therapeutics 09/2014