Wei Xiang Selected Research

Parkinson Disease (Parkinson's Disease)

4/2024	Detecting Misfolded α-Synuclein in Blood Years before the Diagnosis of Parkinson's Disease.
12/2023	Young human alpha synuclein transgenic (BAC-SNCA) mice display sex- and gene-dose-dependent phenotypic disturbances.
8/2023	The Bidirectional Interplay of α-Synuclein with Lipids in the Central Nervous System and Its Implications for the Pathogenesis of Parkinson's Disease.
12/2022	Translocation of Distinct Alpha Synuclein Species from the Nucleus to Neuronal Processes during Neuronal Differentiation.
12/2022	Generation of a homozygous and a heterozygous SNCA gene knockout human-induced pluripotent stem cell line by CRISPR/Cas9 mediated allele-specific tuning of SNCA expression.
2/2022	Interaction of Alpha Synuclein and Microtubule Organization Is Linked to Impaired Neuritic Integrity in Parkinson's Patient-Derived Neuronal Cells.
1/2022	Detection of neuron-derived pathological α-synuclein in blood.
1/2022	Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models.
1/2021	A glutaminyl cyclase-catalyzed α-synuclein modification identified in human synucleinopathies.
1/2021	Efficacy and Safety of Pramipexole Sustained Release versus Immediate Release Formulation for Nocturnal Symptoms in Chinese Patients with Advanced Parkinson's Disease: A Pilot Study.

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Wei Xiang Research Topics

Disease

79	Neoplasms (Cancer) 04/2024 - 05/2002
26	Glioma (Gliomas) 05/2023 - 01/2002
23	Parkinson Disease (Parkinson's Disease) 04/2024 - 05/2013
15	Inflammation (Inflammations) 04/2024 - 06/2010
14	Synucleinopathies 12/2023 - 09/2013
10	Urinary Bladder Neoplasms (Bladder Cancer) 12/2022 - 02/2014
9	Neurodegenerative Diseases (Neurodegenerative Disease) 08/2023 - 01/2016
9	Glioblastoma (Glioblastoma Multiforme) 01/2021 - 01/2016
8	Obesity 12/2024 - 10/2003
8	Infections 02/2024 - 01/2007
7	Neoplasm Metastasis (Metastasis) 03/2024 - 01/2017
6	Systemic Lupus Erythematosus (Libman-Sacks Disease) 08/2023 - 01/2016
6	Stroke (Strokes) 07/2022 - 01/2015
5	Carcinogenesis 03/2024 - 10/2014
5	Osteoarthritis 10/2023 - 01/2018
5	Carcinoma (Carcinomatosis) 03/2022 - 06/2003
5	Colorectal Neoplasms (Colorectal Cancer) 10/2020 - 06/2003
4	Liver Neoplasms (Liver Cancer) 04/2024 - 01/2020
4	Bites and Stings (Sting) 01/2024 - 10/2021
4	Cognitive Dysfunction 05/2023 - 11/2018
4	Hepatocellular Carcinoma (Hepatoma) 01/2022 - 07/2018
4	Osteosarcoma (Osteogenic Sarcoma) 12/2021 - 01/2020
4	Insulin Resistance 01/2021 - 09/2015
4	Hypoxia (Hypoxemia) 03/2020 - 11/2017
4	Renal Cell Carcinoma (Grawitz Tumor) 01/2020 - 02/2015
4	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 09/2019 - 10/2015
4	Atherosclerosis 04/2017 - 07/2005
3	Breast Neoplasms (Breast Cancer) 01/2024 - 03/2015
3	Pathologic Processes 10/2023 - 01/2021
3	Autistic Disorder (Autism) 01/2023 - 01/2018
3	Autism Spectrum Disorder 01/2023 - 01/2018
3	Mitochondrial Diseases (Mitochondrial Disease) 01/2023 - 01/2017
3	Fibrosis (Cirrhosis) 01/2023 - 06/2009
3	Ischemic Stroke 07/2022 - 10/2017
3	Lung Neoplasms (Lung Cancer) 03/2022 - 01/2020
3	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 03/2022 - 02/2016
3	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 01/2021
3	Ischemia 01/2021 - 08/2015
3	Type 2 Diabetes Mellitus (MODY) 01/2021 - 04/2014
3	Ovarian Neoplasms (Ovarian Cancer) 01/2019 - 06/2003
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2019 - 12/2016
3	Rheumatoid Arthritis 01/2019 - 01/2016
3	Bone Resorption 01/2018 - 01/2017
3	Dementia (Dementias) 01/2018 - 01/2014
3	Pain (Aches) 12/2017 - 03/2015
3	Chondrosarcoma 07/2017 - 10/2014
3	Hypertension (High Blood Pressure) 11/2006 - 05/2004
2	Knee Osteoarthritis 03/2024 - 07/2023

Drug/Important Bio-Agent (IBA)

30	Proteins (Proteins, Gene)FDA Link 08/2023 - 09/2009
20	Biomarkers (Surrogate Marker)IBA 12/2024 - 01/2013
16	alpha-SynucleinIBA 12/2023 - 05/2013
12	SynucleinsIBA 04/2024 - 09/2013
10	Long Noncoding RNAIBA 01/2022 - 04/2018
10	MicroRNAs (MicroRNA)IBA 03/2021 - 01/2013
8	Messenger RNA (mRNA)IBA 12/2023 - 10/2003
7	LipidsIBA 08/2023 - 10/2003
7	Small Interfering RNA (siRNA)IBA 02/2022 - 01/2016
6	DNA (Deoxyribonucleic Acid)IBA 10/2023 - 01/2004
6	EnzymesIBA 04/2023 - 01/2010
6	Temozolomide (Temodar)FDA LinkGeneric 01/2023 - 01/2016
5	CytokinesIBA 12/2023 - 01/2016
5	Cadherins (E-Cadherin)IBA 01/2023 - 01/2015
5	RNA (Ribonucleic Acid)IBA 12/2022 - 01/2018
5	Tyrosine Kinase InhibitorsIBA 01/2022 - 10/2015
5	Apolipoproteins E (ApoE)IBA 04/2017 - 10/2003
5	Calcitriol Receptors (Calcitriol Receptor)IBA 01/2017 - 05/2004
4	Peptides (Polypeptides)IBA 02/2024 - 01/2018
4	Therapeutic UsesIBA 08/2023 - 01/2004
4	Hormones (Hormone)IBA 01/2023 - 06/2016
4	CateninsIBA 01/2023 - 06/2016
4	Prion ProteinsIBA 01/2022 - 04/2007
4	Cisplatin (Platino)FDA LinkGeneric 12/2021 - 01/2002
4	Antineoplastic Agents (Antineoplastics)IBA 07/2021 - 10/2014
4	Superoxide DismutaseIBA 01/2021 - 11/2006
4	ApolipoproteinsIBA 04/2017 - 10/2003
3	Circular RNAIBA 12/2023 - 01/2020
3	Glucose (Dextrose)FDA LinkGeneric 11/2023 - 01/2016
3	InterferonsIBA 08/2023 - 01/2021
3	Vitamin D FDA LinkGeneric 01/2023 - 11/2011
3	MethyltransferasesIBA 01/2022 - 01/2019
3	CholesterolIBA 01/2022 - 10/2003
3	Immunoglobulin G (IgG)IBA 03/2021 - 06/2003
3	Metformin (Glucophage)FDA LinkGeneric 01/2021 - 01/2016
3	Adenosine Triphosphate (ATP)IBA 01/2021 - 08/2015
3	Pramipexole (Mirapex)FDA LinkGeneric 01/2021 - 01/2017
3	Levodopa (L Dopa)FDA LinkGeneric 01/2021 - 01/2017
3	hydroxide ionIBA 11/2020 - 01/2017
3	Oxaliplatin (Eloxatin)FDA LinkGeneric 10/2020 - 01/2019
3	Indicators and Reagents (Reagents)IBA 06/2020 - 06/2013
3	Triglycerides (Triacylglycerol)IBA 11/2019 - 10/2003
3	1,25-dihydroxyvitamin DIBA 11/2011 - 05/2004
2	Fatty Acids (Saturated Fatty Acids)IBA 05/2024 - 01/2020
2	Brain Natriuretic Peptide (Natrecor)FDA Link 02/2024 - 01/2024
2	Interleukin-2 (IL2)IBA 01/2024 - 01/2020
2	Sorafenib (BAY 43-9006)FDA Link 12/2023 - 01/2021

Therapy/Procedure

31	Therapeutics 04/2024 - 06/2003
11	Drug Therapy (Chemotherapy) 05/2023 - 01/2016
6	Immunotherapy 05/2024 - 01/2021
5	Radiotherapy 01/2023 - 01/2018
3	Electrodes (Electrode) 02/2023 - 02/2021