Guoxin Wu Selected Research

Amyloid beta-Peptides

5/2010	Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound.
3/2008	In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.
5/2005	Compounds that bind APP and inhibit Abeta processing in vitro suggest a novel approach to Alzheimer disease therapeutics.

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Guoxin Wu Research Topics

Disease

16	Alzheimer Disease (Alzheimer's Disease) 01/2015 - 01/2004
6	HIV Infections (HIV Infection) 01/2021 - 01/2016
4	Infections 11/2023 - 01/2019
1	Acquired Immunodeficiency Syndrome (AIDS) 10/2022
1	Viremia 10/2022
1	Latent Infection 10/2022
1	Vesicular Stomatitis 08/2022
1	COVID-19 08/2022
1	Ataxia (Dyssynergia) 01/2022
1	Persistent Infection 01/2022
1	Confusion (Bewilderment) 01/2022
1	Lethargy 01/2022
1	Disease Progression 01/2021
1	Inflammation (Inflammations) 01/2021
1	Periarthritis 08/2020
1	B-Cell Lymphoma (Lymphoma, B Cell) 01/2019
1	Spinal Cord Injuries (Spinal Cord Injury) 01/2014
1	Amyloid Plaque 01/2014
1	Pulmonary Embolism 09/2005

Drug/Important Bio-Agent (IBA)

11	Amyloid (Amyloid Fibrils)IBA 01/2015 - 03/2008
9	Proteins (Proteins, Gene)FDA Link 01/2015 - 03/2008
5	Peptides (Polypeptides)IBA 01/2015 - 05/2005
4	EnzymesIBA 01/2015 - 08/2008
4	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 06/2014 - 07/2007
3	DNA (Deoxyribonucleic Acid)IBA 10/2022 - 01/2016
3	RNA (Ribonucleic Acid)IBA 01/2019 - 01/2016
3	Amyloid beta-PeptidesIBA 05/2010 - 05/2005
2	Viral ProteinsIBA 10/2022 - 01/2021
2	Biomarkers (Surrogate Marker)IBA 12/2012 - 08/2008
1	Vorinostat FDA Link 10/2022
1	Tamoxifen FDA LinkGeneric 10/2022
1	Histones (Histone)IBA 10/2022
1	COVID-19 VaccinesIBA 08/2022
1	Ebola VaccinesIBA 08/2022
1	VaccinesIBA 08/2022
1	Disulfiram (Antabuse)FDA Link 01/2022
1	Interleukin-10 (Interleukin 10)IBA 01/2022
1	Transcription Factors (Transcription Factor)IBA 01/2019
1	PanobinostatIBA 01/2016
1	Pyrrolidonecarboxylic Acid (Pyroglutamic Acid)IBA 01/2014
1	VLDL LipoproteinsIBA 09/2010
1	low density lipoprotein receptor-related protein 8IBA 09/2010
1	BatroxobinIBA 09/2005
1	FibrinIBA 09/2005
1	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 01/2004
1	tissue-factor-pathway inhibitor 2 (PP5)IBA 01/2004
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2004
1	Glycogen Synthase (Synthase I)IBA 01/2004

Therapy/Procedure

6	Therapeutics 10/2022 - 05/2005
4	Art Therapy 11/2023 - 01/2020
1	Mucosal Administration 08/2022
1	Moxibustion 08/2020
1	Nerve Transfer 01/2014