Joanne Wiseman Selected Research

Anesthesia

9/2009

The identification of a novel phosphodiesterase 4 inhibitor, 1-ethyl-5-{5-[(4-methyl-1-piperazinyl)methyl]-1,3,4-oxadiazol-2-yl}-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (EPPA-1), with improved therapeutic index using pica feeding in rats as a measure of emetogenicity.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Joanne Wiseman Research Topics

Disease

3	Pain (Aches) 08/2009 - 11/2004
2	Nausea 04/2011 - 09/2009
2	Vomiting 04/2011 - 09/2009
1	Chronic Obstructive Pulmonary Disease (COPD) 04/2011
1	Respiratory Tract Diseases (Respiratory Tract Disease) 04/2011
1	Pica (Geophagia) 09/2009
1	Chronic Pain 03/2005
1	Neuralgia (Stump Neuralgia) 03/2005
1	Hyperalgesia 03/2005

Drug/Important Bio-Agent (IBA)

2	RoflumilastIBA 04/2011 - 09/2009
2	Phosphodiesterase 4 InhibitorsIBA 04/2011 - 09/2009
2	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 08/2009 - 03/2005
2	pyridazineIBA 03/2005 - 11/2004
2	GW406381XIBA 03/2005 - 11/2004
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 04/2011
1	6- ((3- ((dimethylamino)carbonyl)phenyl)sulfonyl)- 8- methyl- 4- ((3- methyloxyphenyl)amino)- 3- quinolinecarboxamideIBA 04/2011
1	AminesIBA 09/2009
1	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 09/2009
1	EmeticsIBA 09/2009
1	PyransIBA 09/2009
1	1- ethyl- 5- (5- ((4- methyl- 1- piperazinyl)methyl)- 1,3,4- oxadiazol- 2- yl)- N- (tetrahydro- 2H- pyran- 4- yl)- 1H- pyrazolo(3,4- b)pyridin- 4- amineIBA 09/2009
1	RolipramIBA 09/2009
1	CilomilastIBA 09/2009
1	Type 4 Cyclic Nucleotide PhosphodiesterasesIBA 09/2009
1	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 03/2005
1	EnzymesIBA 03/2005
1	rofecoxib (Vioxx)FDA Link 03/2005
1	Celecoxib (Celebrex)FDA Link 03/2005
1	Analgesics (Analgesic Drugs)IBA 11/2004
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 11/2004

Therapy/Procedure

1	Anesthesia 09/2009
1	Ligation 03/2005