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Helen R Wheeler Selected Research

Therapeutics

2/2021Are In Vitro Human Blood-Brain-Tumor-Barriers Suitable Replacements for In Vivo Models of Brain Permeability for Novel Therapeutics?
1/2019Sub-acute Toxicity in Non-cancerous Tissue and Immune-Related Adverse Events of a Novel Combination Therapy for Cancer.
1/2018Glioblastoma Recurrence Correlates With Increased APE1 and Polarization Toward an Immuno-Suppressive Microenvironment.
5/2017Biomarker and Histopathology Evaluation of Patients with Recurrent Glioblastoma Treated with Galunisertib, Lomustine, or the Combination of Galunisertib and Lomustine.

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Helen R Wheeler Research Topics

Disease

13Glioblastoma (Glioblastoma Multiforme)
04/2023 - 03/2008
10Neoplasms (Cancer)
09/2023 - 03/2008
9Glioma (Gliomas)
03/2024 - 05/2013
3Astrocytoma (Pilocytic Astrocytoma)
06/2023 - 10/2008
1Disease Progression
09/2023
1Medulloblastoma
03/2022
1Brain Neoplasms (Brain Tumor)
02/2021
1Lymphopenia (Lymphocytopenia)
01/2019
1Thrombocytopenia (Thrombopenia)
01/2019
1Venous Thrombosis (Deep-Vein Thrombosis)
01/2018
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2018
1Necrosis
03/2015
1Oligodendroglioma
03/2011
1Seizures (Absence Seizure)
03/2011
1Leukemia
07/2010

Drug/Important Bio-Agent (IBA)

5Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA
06/2023 - 05/2013
4Biomarkers (Surrogate Marker)IBA
03/2024 - 08/2010
4Temozolomide (Temodar)FDA LinkGeneric
01/2018 - 03/2008
3Proteins (Proteins, Gene)FDA Link
03/2024 - 10/2008
3Bevacizumab (Avastin)FDA Link
10/2021 - 03/2015
3MethyltransferasesIBA
03/2016 - 03/2008
2GadoliniumIBA
07/2018 - 08/2010
2LY-2157299IBA
05/2017 - 01/2016
2Transforming Growth Factors (Transforming Growth Factor)IBA
05/2017 - 01/2016
2Lomustine (CCNU)FDA Link
05/2017 - 01/2016
2Phosphotransferases (Kinase)IBA
05/2017 - 01/2016
2DNA (Deoxyribonucleic Acid)IBA
03/2016 - 03/2008
2Indicators and Reagents (Reagents)IBA
12/2013 - 08/2010
1Dexamethasone (Maxidex)FDA LinkGeneric
09/2023
1Acetazolamide (Diamox)FDA LinkGeneric
09/2023
1Adrenal Cortex Hormones (Corticosteroids)IBA
09/2023
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
04/2023
1sonidegibIBA
03/2022
1SteroidsIBA
10/2021
1ChemokinesIBA
01/2020
1CytokinesIBA
01/2020
1factor V LeidenIBA
01/2018
1Conditioned Culture MediaIBA
01/2018
1Glial Fibrillary Acidic ProteinIBA
05/2017
1Chemokine CCL22IBA
05/2017
1O-(6)-methylguanineIBA
03/2016
1DNA Repair EnzymesIBA
03/2016
1MicroRNAs (MicroRNA)IBA
12/2013
1ParaffinIBA
07/2010
1Messenger RNA (mRNA)IBA
10/2008
1Prostaglandins DIBA
10/2008
1prostaglandin R2 D-isomerase (prostaglandin D2 synthase)IBA
10/2008
1ProstaglandinsIBA
10/2008
1Arachidonic Acid (Vitamin F)IBA
10/2008
1LipocalinsIBA
10/2008
1O(6)-Methylguanine-DNA MethyltransferaseIBA
03/2008

Therapy/Procedure

6Radiotherapy
01/2022 - 12/2013
4Therapeutics
02/2021 - 05/2017
2Craniotomy
10/2021 - 03/2015
2Immunotherapy
01/2020 - 01/2019
2Drug Therapy (Chemotherapy)
01/2018 - 12/2013
2Chemoradiotherapy
01/2016 - 04/2015
1Re-Irradiation
03/2015
1Adjuvant Chemotherapy
03/2011
1Aftercare (After-Treatment)
03/2008