John Wharton Selected Research

Channelopathies

10/2018

Loss-of-Function ABCC8 Mutations in Pulmonary Arterial Hypertension.

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John Wharton Research Topics

Disease

27	Pulmonary Arterial Hypertension 04/2024 - 02/2003
18	Pulmonary Hypertension 10/2023 - 03/2002
11	Hypoxia (Hypoxemia) 11/2022 - 12/2002
11	Familial Primary Pulmonary Hypertension 10/2020 - 03/2002
4	Iron Deficiencies 01/2021 - 07/2011
3	Rare Diseases (Rare Disease) 12/2022 - 11/2017
3	Anemia 01/2021 - 07/2011
3	Vascular Remodeling 06/2016 - 07/2009
2	Inflammation (Inflammations) 01/2019 - 01/2019
1	Starvation 04/2024
1	Body Weight (Weight, Body) 01/2021
1	Disease Susceptibility (Diathesis) 01/2020
1	Insulin Resistance 01/2019
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2019
1	Pulmonary Embolism 01/2019
1	Channelopathies 10/2018
1	Lymphadenopathy 11/2017
1	Pulmonary Veno-Occlusive Disease (Veno Occlusive Disease, Pulmonary) 11/2017
1	Neoplasms (Cancer) 10/2017
1	Pneumonia (Pneumonitis) 01/2017
1	Vascular Diseases (Vascular Disease) 09/2013
1	Cardiovascular Diseases (Cardiovascular Disease) 02/2013
1	Hepatocellular Carcinoma (Hepatoma) 07/2011
1	Hypertrophy 05/2010

Drug/Important Bio-Agent (IBA)

6	Proteins (Proteins, Gene)FDA Link 01/2019 - 11/2010
5	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 12/2022 - 11/2010
5	IronIBA 01/2021 - 07/2011
4	Biomarkers (Surrogate Marker)IBA 01/2022 - 07/2011
3	MonocrotalineIBA 10/2023 - 01/2018
3	ProteomeIBA 01/2022 - 01/2017
3	MicroRNAs (MicroRNA)IBA 07/2021 - 01/2013
3	Ferritins (Ferritin)IBA 01/2021 - 07/2011
3	Transferrin (beta 2 Transferrin)IBA 01/2021 - 07/2011
3	ferric carboxymaltoseIBA 01/2021 - 01/2013
2	pro-brain natriuretic peptide (1-76)IBA 01/2022 - 07/2011
2	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2022 - 07/2011
2	RNA (Ribonucleic Acid)IBA 10/2020 - 01/2020
2	Lipoproteins (Lipoprotein)IBA 01/2019 - 01/2019
2	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 10/2017
2	Nitric Oxide Synthase (NO Synthase)IBA 08/2014 - 09/2013
2	N,N-dimethylarginine (asymmetric dimethylarginine)IBA 08/2014 - 09/2013
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 04/2014 - 11/2010
2	ChloridesIBA 04/2014 - 11/2010
2	Valproic Acid (Depakote)FDA LinkGeneric 04/2013 - 07/2012
2	HepcidinsIBA 01/2013 - 07/2011
2	CreatinineIBA 01/2013 - 07/2011
2	Sildenafil Citrate (Viagra)FDA Link 07/2005 - 07/2003
2	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 07/2005 - 07/2003
1	Thrombin FDA Link 04/2024
1	PolyaminesIBA 04/2024
1	Adenosine Triphosphatases (ATPase)IBA 04/2024
1	Cathepsin ZIBA 01/2024
1	Transcription Factor 4IBA 12/2022
1	Dextrans (Dextran)FDA Link 01/2021
1	Semaxinib (SU5416)IBA 01/2021
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2021
1	LipidsIBA 01/2019
1	N 30IBA 01/2019
1	HLA-DPA1 antigen (HLA DPA1)IBA 01/2019
1	AntigensIBA 01/2019
1	HLA-DPB1 antigen (HLA DPB1)IBA 01/2019
1	PotassiumIBA 10/2018
1	Phosphotransferases (Kinase)IBA 11/2017
1	Carbon MonoxideIBA 11/2017
1	Prokaryotic Initiation Factor-2IBA 11/2017
1	DNA (Deoxyribonucleic Acid)IBA 11/2017
1	Adenosine Triphosphate (ATP)IBA 10/2017
1	Pyruvate Dehydrogenase Acetyl-Transferring KinaseIBA 10/2017
1	Mixed Function Oxygenases (Monooxygenases)IBA 06/2016
1	EndoglinIBA 01/2016
1	SurvivinIBA 05/2015
1	Imatinib Mesylate (Gleevec)FDA Link 05/2015
1	Messenger RNA (mRNA)IBA 08/2014
1	Endothelin-1 (Endothelin 1)IBA 04/2014
1	Connexin 43 (Connexin43)IBA 09/2013
1	AngiopoietinsIBA 01/2013
1	Uric Acid (Urate)IBA 01/2013
1	Interleukin-6 (Interleukin 6)IBA 01/2013
1	Histone Deacetylase InhibitorsIBA 07/2012
1	Histones (Histone)IBA 07/2012
1	Vorinostat FDA Link 07/2012
1	Histone Deacetylases (Histone Deacetylase)IBA 07/2012
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 10/2011
1	Bone Morphogenetic Protein ReceptorsIBA 07/2011
1	Transferrin Receptors (Transferrin Receptor)IBA 07/2011
1	InterleukinsIBA 07/2011
1	Transforming Growth Factors (Transforming Growth Factor)IBA 11/2010
1	Simvastatin (Zocor)FDA LinkGeneric 05/2010
1	Caveolin 1IBA 07/2009
1	Phosphodiesterase 5 InhibitorsIBA 07/2005
1	Vasodilator Agents (Vasodilators)IBA 02/2003
1	ProstaglandinsIBA 12/2002
1	Prostaglandins FIBA 12/2002
1	Prostaglandins DIBA 12/2002
1	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 12/2002
1	p38 Mitogen-Activated Protein KinasesIBA 12/2002
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 12/2002

Therapy/Procedure

6	Therapeutics 01/2021 - 03/2002
2	Endarterectomy (Thromboendarterectomy) 01/2021 - 01/2019
1	Precision Medicine 01/2021