Jennifer J Westendorf Selected Research

Bone Resorption

10/2023	Pulling rank with RNA: RANKL promotes the association of PGC-1β/RNA complexes with NCoR/HDAC3 to activate gene expression in osteoclasts.
11/2019	Lung tumor cells inhibit bone mineralization and osteoblast activity.
1/2019	Deficiency in the phosphatase PHLPP1 suppresses osteoclast-mediated bone resorption and enhances bone formation in mice.
1/2018	The Deletion of Hdac4 in Mouse Osteoblasts Influences Both Catabolic and Anabolic Effects in Bone.
1/2016	Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling.
10/2015	Histone Deacetylases in Bone Development and Skeletal Disorders.
7/2015	Conditional deletion of Hdac3 in osteoprogenitor cells attenuates diet-induced systemic metabolic dysfunction.
11/2013	Transforming growth factor beta 1 induces CXCL16 and leukemia inhibitory factor expression in osteoclasts to modulate migration of osteoblast progenitors.
2/2013	Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through S1P activation of complementary kinase pathways.
5/2011	Suberoylanilide hydroxamic acid (SAHA; vorinostat) causes bone loss by inhibiting immature osteoblasts.

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Jennifer J Westendorf Research Topics

Disease

26	Neoplasms (Cancer) 01/2021 - 10/2004
12	Bone Resorption 10/2023 - 03/2010
6	Osteoporosis 01/2019 - 12/2005
4	Neoplasm Metastasis (Metastasis) 01/2021 - 01/2007
4	Osteoarthritis 01/2021 - 01/2016
4	Prostatic Neoplasms (Prostate Cancer) 01/2018 - 01/2002
4	Carcinogenesis 01/2018 - 04/2004
3	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2018 - 12/2015
3	Hypertrophy 01/2018 - 05/2006
3	Nervous System Diseases (Neurological Disorders) 01/2017 - 01/2016
3	Metabolic Bone Diseases (Osteopenia) 01/2016 - 10/2009
3	Epilepsy (Aura) 10/2015 - 03/2011
3	Ewing Sarcoma (Sarcoma, Ewing) 12/2014 - 06/2010
3	Bone Diseases (Bone Disease) 06/2013 - 10/2004
2	Inflammation (Inflammations) 09/2023 - 04/2015
2	Chondroblastoma 01/2021 - 06/2016
2	Sarcoma (Soft Tissue Sarcoma) 12/2014 - 02/2007
2	Genetic Translocation (Chromosomal Translocation) 12/2014 - 07/2014
1	Chronic Disease (Chronic Diseases) 11/2023
1	Lateral meningocele syndrome 03/2021
1	Kyphosis 03/2021
1	Muscular Diseases (Myopathy) 03/2021
1	Giant Cell Tumors (Giant Cell Tumor) 01/2021
1	Chromosomal Instability (Chromosome Stability) 01/2021
1	Neuroblastoma 01/2021
1	Brain Neoplasms (Brain Tumor) 10/2020
1	Adenocarcinoma of Lung 11/2019
1	Intervertebral Disc Degeneration 10/2019
1	Type 2 Diabetes Mellitus (MODY) 01/2018
1	Hyperalgesia 01/2018
1	Insulin Resistance 01/2018
1	Mood Disorders (Mood Disorder) 12/2017
1	HIV Infections (HIV Infection) 10/2015
1	Arthritis (Polyarthritis) 10/2015
1	Heart Diseases (Heart Disease) 10/2015

Drug/Important Bio-Agent (IBA)

7	Proteins (Proteins, Gene)FDA Link 01/2019 - 05/2003
6	Histone Deacetylases (Histone Deacetylase)IBA 01/2018 - 10/2007
6	Histone Deacetylase InhibitorsIBA 12/2017 - 12/2010
5	Transcription Factors (Transcription Factor)IBA 05/2011 - 01/2002
3	Histones (Histone)IBA 01/2021 - 06/2016
3	Parathyroid Hormone (Parathormone)IBA 11/2019 - 02/2008
3	Hormones (Hormone)IBA 11/2019 - 01/2002
2	Co-Repressor ProteinsIBA 10/2023 - 05/2006
2	CytokinesIBA 09/2023 - 01/2016
2	ChromatinIBA 01/2021 - 01/2019
2	Biomarkers (Surrogate Marker)IBA 11/2019 - 01/2019
2	MineralsIBA 11/2019 - 10/2015
2	Parathyroid Hormone-Related ProteinIBA 11/2019 - 12/2010
2	AndrogensIBA 01/2018 - 01/2002
2	Androgen Receptors (Androgen Receptor)IBA 01/2018 - 01/2018
2	Anabolic AgentsIBA 01/2018 - 12/2005
2	ChemokinesIBA 01/2018 - 02/2013
2	EnzymesIBA 01/2016 - 04/2004
2	OsteocalcinIBA 07/2015 - 01/2002
2	EWS-FLI fusion proteinIBA 12/2014 - 11/2010
2	CateninsIBA 02/2013 - 04/2011
2	LuciferasesIBA 02/2007 - 01/2002
1	(N- (3- phenylpropionyl)- N- (phenethyl))- glycyl- borolysineIBA 03/2021
1	Small Cytoplasmic RNAIBA 01/2021
1	N-Myc Proto-Oncogene ProteinIBA 01/2021
1	Histone MethyltransferasesIBA 01/2021
1	Nucleosomes (Nucleosome)IBA 01/2021
1	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 10/2020
1	alpha-hydroxyglutarateIBA 10/2020
1	CalciumIBA 11/2019
1	1,25-dihydroxyvitamin DIBA 11/2019
1	Phosphates (Orthophosphate)IBA 11/2019
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2019
1	Protein Isoforms (Isoforms)IBA 01/2019
1	Testosterone (Sustanon)FDA Link 01/2018
1	Androgen Antagonists (Antiandrogens)IBA 01/2018
1	Alkaline PhosphataseIBA 01/2018
1	LigandsIBA 01/2018
1	abirateroneIBA 01/2018
1	Phosphoprotein Phosphatases (Phosphatases, Protein)IBA 01/2018
1	ProdrugsIBA 01/2018
1	Abiraterone AcetateIBA 01/2018
1	NSC117079IBA 01/2018
1	RGFP966IBA 01/2018
1	Collagenases (Collagenase)FDA Link 01/2018
1	CXCR4 Receptors (CXCR4 Receptor)IBA 01/2018
1	OsteoprotegerinIBA 01/2018
1	Receptor Activator of Nuclear Factor-kappa B (TRANCE-R)IBA 01/2018
1	Cholesterol Side-Chain Cleavage Enzyme (CYP11A1)IBA 01/2018
1	Cytarabine (Cytosar-U)FDA LinkGeneric 11/2017
1	TeratogensIBA 01/2017
1	Estrogens (Estrogen)FDA Link 11/2016
1	Mutant Proteins (Protein, Mutant)IBA 06/2016
1	MethyltransferasesIBA 06/2016
1	Peptide Hydrolases (Proteases)FDA Link 01/2016
1	histone deacetylase 3IBA 01/2016
1	Janus KinasesIBA 01/2016
1	SirtuinsIBA 10/2015

Therapy/Procedure

10	Therapeutics 11/2023 - 10/2004
1	Sutures (Suture) 10/2020
1	Punctures 10/2019
1	Intra-Articular Injections 01/2018
1	Castration 01/2018
1	Drug Therapy (Chemotherapy) 11/2017
1	Combination Drug Therapy (Combination Chemotherapy) 12/2015