Nancy L Weigel Selected Research

Ligands

1/2021	Isoform-specific Activities of Androgen Receptor and its Splice Variants in Prostate Cancer Cells.
1/2018	Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer.
8/2009	Coactivator selective regulation of androgen receptor activity.
10/2006	Androgen receptor action in hormone-dependent and recurrent prostate cancer.
2/2005	c-Jun N-terminal kinase contributes to aberrant retinoid signaling in lung cancer cells by phosphorylating and inducing proteasomal degradation of retinoic acid receptor alpha.
12/2002	A novel androgen receptor mutant, A748T, exhibits hormone concentration-dependent defects in nuclear accumulation and activity despite normal hormone-binding affinity.

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Nancy L Weigel Research Topics

Disease

48	Prostatic Neoplasms (Prostate Cancer) 01/2022 - 01/2002
26	Neoplasms (Cancer) 01/2022 - 01/2002
7	Breast Neoplasms (Breast Cancer) 02/2016 - 04/2005
3	Neoplasm Metastasis (Metastasis) 07/2009 - 01/2002
2	Carcinoma (Carcinomatosis) 07/2009 - 12/2007
1	Hypercalcemia (Milk Alkali Syndrome) 07/2017
1	Acquired Immunodeficiency Syndrome (AIDS) 11/2006
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 05/2006
1	Lung Neoplasms (Lung Cancer) 02/2005
1	Carcinogenesis 12/2004
1	Ovarian Neoplasms (Ovarian Cancer) 12/2004
1	Bone Resorption 07/2004
1	Metabolic Bone Diseases (Osteopenia) 07/2004

Drug/Important Bio-Agent (IBA)

28	AndrogensIBA 01/2022 - 03/2003
26	Androgen Receptors (Androgen Receptor)IBA 01/2022 - 12/2002
11	Hormones (Hormone)IBA 02/2016 - 04/2003
8	Vitamin D FDA LinkGeneric 07/2017 - 01/2002
8	1,25-dihydroxyvitamin DIBA 04/2010 - 01/2003
7	Messenger RNA (mRNA)IBA 05/2021 - 02/2006
7	Calcitriol Receptors (Calcitriol Receptor)IBA 07/2017 - 12/2004
6	LigandsIBA 01/2021 - 12/2002
6	Proteins (Proteins, Gene)FDA Link 01/2016 - 06/2005
5	seocalcitolIBA 09/2014 - 07/2004
5	Calcitriol (Calcijex)FDA LinkGeneric 04/2010 - 01/2002
4	Parathyroid Hormone-Related ProteinIBA 07/2009 - 02/2006
3	bicalutamide (Casodex)FDA LinkGeneric 01/2016 - 09/2005
3	RetinoidsIBA 05/2006 - 09/2003
2	Androgen Antagonists (Antiandrogens)IBA 01/2018 - 01/2016
2	EnzymesIBA 07/2017 - 01/2016
2	Vitamin D3 24-HydroxylaseIBA 07/2017 - 09/2014
2	Phosphotransferases (Kinase)IBA 02/2016 - 10/2014
2	Progesterone Receptors (Progesterone Receptor)IBA 10/2014 - 12/2004
2	Progestins (Progestagens)IBA 10/2014 - 08/2011
2	Estrogen ReceptorsIBA 10/2014 - 05/2010
2	Small Interfering RNA (siRNA)IBA 01/2011 - 03/2006
2	Retinoic Acid Receptor alphaIBA 05/2006 - 02/2005
2	JNK Mitogen-Activated Protein KinasesIBA 05/2006 - 02/2005
2	Tretinoin (Retinoic Acid)FDA LinkGeneric 09/2003 - 01/2003
1	TransferasesIBA 01/2022
1	UGT2B28 UDP-glucuronosyltransferase (UGT2B28)IBA 01/2022
1	Uridine Diphosphate (UDP)IBA 01/2022
1	Protein Isoforms (Isoforms)IBA 01/2021
1	Glucosamine 6-Phosphate N-Acetyltransferase (Glucosamine-Phosphate N-Acetyltransferase)IBA 01/2016
1	Co-Repressor ProteinsIBA 01/2016
1	HexosaminesIBA 01/2016
1	abirateroneIBA 12/2014
1	enzalutamideIBA 12/2014
1	Aromatase InhibitorsIBA 10/2014
1	Phenobarbital (Luminal)FDA Link 10/2014
1	Cyclin A2IBA 10/2014
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2013
1	STA 9090IBA 01/2013
1	Molecular Chaperones (Chaperone, Molecular)IBA 01/2013
1	phosphatidylinositol-3,4-bisphosphate 4-phosphataseIBA 01/2011
1	Retinoblastoma ProteinIBA 01/2011
1	ThymidineIBA 01/2011
1	Estrogen Receptor alphaIBA 05/2010
1	Tamoxifen FDA LinkGeneric 05/2010
1	Estrogen Receptor Modulators (Antiestrogen)IBA 05/2010
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 08/2009
1	Integrin alpha6beta4IBA 07/2009
1	Transcription Factors (Transcription Factor)IBA 05/2009
1	Mitogen-Activated Protein Kinase 3IBA 11/2008
1	Nuclear Receptor Coactivator 2IBA 11/2006
1	Prostate-Specific Antigen (Semenogelase)IBA 10/2006
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 03/2006
1	p38 Mitogen-Activated Protein KinasesIBA 03/2006
1	SteroidsIBA 03/2006
1	Phosphoprotein Phosphatases (Phosphatases, Protein)IBA 03/2006
1	MagnesiumIBA 03/2006
1	4- (4- fluorophenyl)- 2- (4- hydroxyphenyl)- 5- (4- pyridyl)imidazoleIBA 03/2006
1	prostatic acid phosphataseIBA 10/2005
1	Insulin-Like Growth Factor Binding Protein 3IBA 06/2005
1	Insulin-Like Growth Factor Binding ProteinsIBA 06/2005
1	Insulin-Like PeptidesIBA 06/2005
1	Chloramphenicol O-Acetyltransferase (Chloramphenicol Acetyltransferase)IBA 04/2005
1	Genetic Markers (Genetic Marker)IBA 12/2004
1	Calcifediol (Calcidiol)FDA Link 12/2004
1	CaspasesIBA 12/2004
1	CalciumIBA 07/2004
1	Transforming Growth Factor beta (TGF-beta)IBA 05/2004
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 04/2004
1	Dihydrotestosterone (Androstanolone)IBA 04/2003
1	DNA (Deoxyribonucleic Acid)IBA 03/2003

Therapy/Procedure

18	Therapeutics 01/2022 - 03/2003
13	Castration 01/2022 - 01/2011
1	Aftercare (After-Treatment) 12/2014
1	Prostatectomy (Retropubic Prostatectomy) 01/2011