Jonathan K Watts Selected Research

Therapeutics

4/2024	Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo.
11/2022	Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state.
11/2022	Harnessing nucleic acid technologies for human health on earth and in space.
9/2017	Locked Nucleic Acid Gapmers and Conjugates Potently Silence ADAM33, an Asthma-Associated Metalloprotease with Nuclear-Localized mRNA.

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Jonathan K Watts Research Topics

Disease

3	Neoplasms (Cancer) 04/2024 - 01/2018
2	Brain Neoplasms (Brain Tumor) 04/2024 - 01/2018
2	Friedreich Ataxia (Friedreich's Ataxia) 12/2022 - 01/2018
2	Inborn Genetic Diseases (Disease, Hereditary) 11/2022 - 06/2022
1	Glioblastoma (Glioblastoma Multiforme) 04/2024
1	Central Nervous System Diseases (CNS Diseases) 01/2024
1	COVID-19 01/2023
1	Fragile X Syndrome (Martin Bell Syndrome) 01/2023
1	Protein Deficiency 12/2022
1	Tyrosinemias (Tyrosinemia) 06/2022
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2022
1	Frontotemporal Dementia (Semantic Dementia) 01/2022
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2020
1	Fuchs' Endothelial Dystrophy 01/2018
1	Glioma (Gliomas) 01/2018
1	Nervous System Diseases (Neurological Disorders) 01/2018
1	Asthma (Bronchial Asthma) 09/2017
1	Neurodegenerative Diseases (Neurodegenerative Disease) 04/2011
1	Machado-Joseph Disease (Spinocerebellar Ataxia Type 3) 04/2011

Drug/Important Bio-Agent (IBA)

4	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2011
3	Antisense OligonucleotidesIBA 01/2024 - 09/2017
2	OligonucleotidesIBA 04/2024 - 01/2018
2	Small Interfering RNA (siRNA)IBA 04/2024 - 01/2020
2	FrataxinIBA 12/2022 - 01/2018
2	RNA (Ribonucleic Acid)IBA 06/2022 - 01/2018
2	Messenger RNA (mRNA)IBA 01/2018 - 09/2017
1	Antiviral Agents (Antivirals)IBA 01/2023
1	BESIBA 06/2022
1	poly(glycyl-alanyl)IBA 01/2022
1	DipeptidesIBA 01/2022
1	locked nucleic acidIBA 09/2017
1	Metalloproteases (Metalloproteinases)IBA 09/2017
1	Ataxin-3IBA 04/2011

Therapy/Procedure

4	Therapeutics 04/2024 - 09/2017
1	Transplantation 01/2018