Helle S Waagepetersen Selected Research

Neurotransmitter Agents (Neurotransmitter)

10/2021	Downregulation of GABA Transporter 3 (GAT3) is Associated with Deficient Oxidative GABA Metabolism in Human Induced Pluripotent Stem Cell-Derived Astrocytes in Alzheimer's Disease.
1/2021	Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease.
1/2021	Functional Metabolic Mapping Reveals Highly Active Branched-Chain Amino Acid Metabolism in Human Astrocytes, Which Is Impaired in iPSC-Derived Astrocytes in Alzheimer's Disease.
7/2015	Effects of ketone bodies in Alzheimer's disease in relation to neural hypometabolism, β-amyloid toxicity, and astrocyte function.
6/2011	Synthesis of neurotransmitter GABA via the neuronal tricarboxylic acid cycle is elevated in rats with liver cirrhosis consistent with a high GABAergic tone in chronic hepatic encephalopathy.
8/2010	Obesity and type 2 diabetes in rats are associated with altered brain glycogen and amino-acid homeostasis.
10/2003	Compartmentation of glutamine, glutamate, and GABA metabolism in neurons and astrocytes: functional implications.

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Helle S Waagepetersen Research Topics

Disease

10	Alzheimer Disease (Alzheimer's Disease) 12/2023 - 07/2015
8	Hepatic Encephalopathy 12/2014 - 03/2009
7	Hyperammonemia 01/2021 - 06/2007
5	Type 2 Diabetes Mellitus (MODY) 01/2019 - 08/2010
3	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2021 - 01/2017
3	Epilepsy (Aura) 01/2019 - 11/2018
2	Huntington Disease (Huntington's Disease) 01/2021 - 06/2019
2	Frontotemporal Dementia (Semantic Dementia) 01/2020 - 01/2017
2	Chromosome 3-Linked Frontotemporal Dementia 01/2020 - 01/2017
2	Mitochondrial Diseases (Mitochondrial Disease) 06/2017 - 03/2014
2	Obesity 01/2017 - 08/2010
2	Neoplasms (Cancer) 01/2017 - 06/2013
2	Seizures (Absence Seizure) 07/2015 - 08/2014
2	Brain Edema (Cerebral Edema) 03/2014 - 08/2013
2	Fibrosis (Cirrhosis) 01/2014 - 01/2013
2	Liver Cirrhosis (Hepatic Cirrhosis) 01/2014 - 06/2011
1	Neurodevelopmental Disorders 01/2022
1	Autism Spectrum Disorder 01/2022
1	Persistent Infection 01/2020
1	Multiple Abnormalities 01/2019
1	Amyloid Plaque 06/2017
1	Cognitive Dysfunction 01/2016
1	Body Weight (Weight, Body) 01/2016
1	Dementia (Dementias) 07/2015
1	Inflammation (Inflammations) 07/2015
1	Temporal Lobe Epilepsy 08/2014
1	Acidosis 06/2013
1	Ischemia 01/2012
1	Hypoglycemia (Reactive Hypoglycemia) 01/2012
1	Edema (Dropsy) 09/2011
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 08/2010
1	Starvation 07/2009
1	Nervous System Diseases (Neurological Disorders) 10/2003

Drug/Important Bio-Agent (IBA)

12	Glutamic Acid (Glutamate)FDA Link 12/2023 - 10/2003
9	Glutamine (L-Glutamine)FDA Link 01/2021 - 03/2009
9	AmmoniaIBA 01/2021 - 03/2009
7	Glucose (Dextrose)FDA LinkGeneric 12/2023 - 07/2009
7	Neurotransmitter Agents (Neurotransmitter)IBA 10/2021 - 10/2003
5	GlycogenIBA 01/2019 - 08/2010
4	Branched-Chain Amino AcidsIBA 01/2021 - 03/2009
3	Amyloid (Amyloid Fibrils)IBA 10/2021 - 07/2015
3	gamma-Aminobutyric Acid (GABA)IBA 10/2021 - 10/2003
3	Amino Acids FDA Link 01/2021 - 03/2009
3	Alanine (L-Alanine)FDA Link 01/2021 - 09/2011
3	Glutamate-Ammonia Ligase (Glutamine Synthetase)IBA 01/2019 - 08/2013
3	Ketone BodiesIBA 03/2017 - 07/2009
3	Tricarboxylic AcidsIBA 04/2011 - 06/2007
2	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2017
2	Oxygen (Dioxygen)IBA 01/2017 - 01/2013
2	Pyruvic Acid (Pyruvate)IBA 01/2016 - 06/2007
1	ProteomeIBA 01/2022
1	GABA Plasma Membrane Transport ProteinsIBA 10/2021
1	Alanine Transaminase (SGPT)IBA 01/2021
1	Glutamate DehydrogenaseIBA 01/2021
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2020
1	EnzymesIBA 01/2020
1	fluorocitrateIBA 01/2019
1	Aconitate Hydratase (Aconitase)IBA 01/2019
1	Anticonvulsants (Antiepileptic Drugs)IBA 01/2019
1	Potassium CyanideIBA 01/2019
1	RotenoneIBA 01/2019
1	Threonine (L-Threonine)FDA Link 01/2019
1	IronIBA 01/2017
1	tyrphostin A23IBA 01/2017
1	Insulin (Novolin)FDA Link 01/2017
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2017
1	KetonesIBA 07/2015
1	Kainic Acid (Kainate)IBA 08/2014
1	Acetates (Acetic Acid Esters)FDA Link 01/2014
1	Methionine SulfoximineIBA 08/2013
1	phenylacetic acid (phenylacetate)FDA Link 01/2013
1	OrnithineIBA 01/2013
1	ornithine phenylacetateIBA 01/2013
1	CarbonIBA 03/2009
1	Isoleucine (L-Isoleucine)FDA Link 03/2009
1	Ketoglutarate Dehydrogenase Complex (Oxoglutarate Dehydrogenase)IBA 06/2007

Therapy/Procedure

1	Ketogenic Diet 07/2009