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Joan Selverstone Valentine Selected Research

Superoxide Dismutase

1/2011Copper and zinc metallation status of copper-zinc superoxide dismutase from amyotrophic lateral sclerosis transgenic mice.
8/2009Radioprotective effects of manganese-containing superoxide dismutase mimics on ataxia-telangiectasia cells.
12/2008Initiation and elongation in fibrillation of ALS-linked superoxide dismutase.
6/2008Structures of the G85R variant of SOD1 in familial amyotrophic lateral sclerosis.
9/2007Metalation of the amyotrophic lateral sclerosis mutant glycine 37 to arginine superoxide dismutase (SOD1) apoprotein restores its structural and dynamical properties in solution to those of metalated wild-type SOD1.
7/2007Metal-free superoxide dismutase forms soluble oligomers under physiological conditions: a possible general mechanism for familial ALS.
2/2007How do ALS-associated mutations in superoxide dismutase 1 promote aggregation of the protein?
6/2006Superoxide dismutase 1 modulates expression of transferrin receptor.
10/2005Fully metallated S134N Cu,Zn-superoxide dismutase displays abnormal mobility and intermolecular contacts in solution.
5/2005Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg.
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Joan Selverstone Valentine Research Topics

Disease

25Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
02/2019 - 05/2002
6Neurodegenerative Diseases (Neurodegenerative Disease)
02/2019 - 11/2002
1Ataxia Telangiectasia (Louis Bar Syndrome)
08/2009
1Parkinsonian Disorders (Parkinsonism)
08/2005
1Motor Neuron Disease (Primary Lateral Sclerosis)
04/2004

Drug/Important Bio-Agent (IBA)

15ZincIBA
12/2015 - 05/2002
15Superoxide DismutaseIBA
01/2011 - 05/2002
14CopperIBA
06/2014 - 05/2002
10Superoxide Dismutase-1IBA
01/2017 - 06/2003
6Proteins (Proteins, Gene)FDA Link
02/2019 - 02/2003
4MetalsIBA
06/2014 - 06/2008
4Superoxides (Superoxide)IBA
06/2014 - 05/2002
2DisulfidesIBA
12/2015 - 06/2008
2EnzymesIBA
07/2007 - 06/2006
1SolventsIBA
02/2019
1HydrogenIBA
12/2009
1AmidesIBA
12/2009
1DeuteriumIBA
12/2009
1ManganeseIBA
08/2009
1Glycine (Aminoacetic Acid)FDA LinkGeneric
09/2007
1ApoproteinsIBA
09/2007
1Arginine (L-Arginine)FDA Link
09/2007
1SolutionsIBA
09/2007
1AntioxidantsIBA
07/2007
1Iron Regulatory Protein 1IBA
06/2006
1Transferrin Receptors (Transferrin Receptor)IBA
06/2006
11-Methyl-4-phenylpyridinium (1 Methyl 4 phenylpyridinium)IBA
08/2005
1Protein AggregatesIBA
11/2002