Naoto Umeda Selected Research

Rheumatoid Arthritis

10/2018	Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis.
1/2017	[The pathogenic role of ACPA in rheumatoid arthritis].
11/2016	Effectiveness of abatacept for patients with Sjögren's syndrome associated with rheumatoid arthritis. An open label, multicenter, one-year, prospective study: ROSE (Rheumatoid Arthritis with Orencia Trial toward Sjögren's syndrome Endocrinopathy) trial.
5/2016	Prevalence of soluble peptidylarginine deiminase 4 (PAD4) and anti-PAD4 antibodies in autoimmune diseases.
1/2016	Evaluation of changes in magnetic resonance images following 24 and 52 weeks of treatment of rheumatoid arthritis with infliximab, tocilizumab, or abatacept.
9/2015	CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis.
3/2015	Efficacy and safety of abatacept for patients with Sjögren's syndrome associated with rheumatoid arthritis: rheumatoid arthritis with orencia trial toward Sjögren's syndrome Endocrinopathy (ROSE) trial-an open-label, one-year, prospective study-Interim analysis of 32 patients for 24 weeks.
1/2015	Subclinical inflammation with tocilizumab treatment of rheumatoid arthritis: MRI evaluation for 2 years.
7/2014	Regulatory roles of tumor necrosis factor alpha-induced proteins (TNFAIPs) 3 and 9 in arthritis.
2/2014	Pulmonary nocardiosis in patients with connective tissue disease: A report of two cases.

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Naoto Umeda Research Topics

Disease

17	Rheumatoid Arthritis 10/2018 - 01/2009
11	Arthritis (Polyarthritis) 11/2019 - 01/2009
4	Immunoglobulin G4-Related Disease 06/2015 - 01/2012
2	Osteoarthritis 10/2018 - 02/2012
2	Systemic Lupus Erythematosus (Libman-Sacks Disease) 10/2018 - 09/2018
2	Experimental Arthritis 10/2018 - 12/2016
1	Hemophagocytic Lymphohistiocytosis (Hemophagocytic Syndrome) 09/2018
1	Periodontal Diseases (Periodontal Disease) 01/2017
1	Autoimmune Diseases (Autoimmune Disease) 05/2016
1	Kimura Disease 04/2016
1	Edema (Dropsy) 01/2016
1	Infections 09/2015
1	Neurosarcoidosis 07/2015
1	Hydrocephalus (Hydrocephaly) 07/2015
1	Prostatitis 06/2015
1	Uveitis 01/2015
1	Inflammation (Inflammations) 01/2015
1	Chronic Kidney Failure (Chronic Renal Failure) 01/2015
1	Fibrosis (Cirrhosis) 05/2014
1	Synovitis 12/2012
1	Skin Ulcer 01/2012
1	Sporotrichosis 01/2012

Drug/Important Bio-Agent (IBA)

8	Proteins (Proteins, Gene)FDA Link 11/2019 - 02/2012
6	Interleukin-6 (Interleukin 6)IBA 11/2019 - 01/2011
5	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2014 - 01/2009
4	Adrenal Cortex Hormones (Corticosteroids)IBA 09/2018 - 05/2014
4	tocilizumab (atlizumab)FDA Link 01/2016 - 01/2012
3	Peptides (Polypeptides)IBA 11/2019 - 01/2017
3	Glucose-6-Phosphate Isomerase (Phosphoglucose Isomerase)IBA 11/2019 - 06/2011
3	Cyclosporine (Ciclosporin)FDA LinkGeneric 09/2018 - 01/2015
3	Abatacept (Orencia)FDA Link 11/2016 - 03/2015
3	Infliximab (Remicade)FDA Link 01/2016 - 01/2009
2	Anti-Citrullinated Protein AntibodiesIBA 11/2019 - 01/2017
2	Protein-Arginine DeiminasesIBA 11/2019 - 05/2016
2	AntibodiesIBA 10/2018 - 05/2016
2	Cyclophosphamide (Cytoxan)FDA LinkGeneric 09/2018 - 01/2012
2	acetyl 4-aminosalicylic acidIBA 01/2017 - 05/2016
2	InterleukinsIBA 12/2016 - 06/2011
2	Methotrexate (Mexate)FDA LinkGeneric 07/2015 - 01/2009
2	Immunoglobulin G (IgG)IBA 05/2014 - 01/2012
2	Prednisolone (Predate)FDA LinkGeneric 02/2014 - 01/2012
1	N- alpha- benzoyl- N5- (2- chloro- 1- iminoethyl)- L- ornithine amideIBA 11/2019
1	arginine deiminaseIBA 11/2019
1	Biomarkers (Surrogate Marker)IBA 10/2018
1	inter-alpha-inhibitorIBA 10/2018
1	HLA-DR Antigens (HLA-DR)IBA 01/2017
1	cyclic citrullinated peptideIBA 01/2017
1	AutoantibodiesIBA 12/2016
1	EpitopesIBA 05/2016
1	Antirheumatic Agents (DMARD)IBA 01/2016
1	Complement System Proteins (Complement)IBA 09/2015
1	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 06/2015
1	SteroidsIBA 01/2015
1	Tumor Necrosis Factor InhibitorsIBA 07/2013
1	Monoclonal AntibodiesIBA 12/2012
1	AntigensIBA 02/2012
1	Interleukin-8 (Interleukin 8)IBA 02/2012
1	GlucocorticoidsIBA 01/2012
1	Immunosuppressive Agents (Immunosuppressants)IBA 01/2012
1	nilotinib FDA Link 06/2011
1	Messenger RNA (mRNA)IBA 06/2011
1	Tyrosine Kinase InhibitorsIBA 06/2011
1	Imatinib Mesylate (Gleevec)FDA Link 06/2011
1	CytokinesIBA 06/2011
1	EnzymesIBA 01/2011
1	Etanercept (Enbrel)FDA Link 01/2010
1	mizoribineIBA 01/2009

Therapy/Procedure

2	Therapeutics 01/2015 - 01/2009
1	Intra-Articular Injections 09/2015
1	Renal Dialysis (Hemodialysis) 01/2015