Jonathan Trent Selected Research

BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)

4/2011	Pharmacokinetics and pharmacodynamics of nilotinib in gastrointestinal stromal tumors.
12/2007	An anticancer C-Kit kinase inhibitor is reengineered to make it more active and less cardiotoxic.

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Jonathan Trent Research Topics

Disease

20	Neoplasms (Cancer) 01/2023 - 12/2003
16	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 01/2024 - 12/2003
15	Sarcoma (Soft Tissue Sarcoma) 01/2023 - 06/2003
6	Leiomyosarcoma 01/2023 - 06/2003
5	Disease Progression 01/2024 - 11/2018
4	Neoplasm Metastasis (Metastasis) 02/2011 - 10/2008
3	Osteosarcoma (Osteogenic Sarcoma) 01/2023 - 04/2010
3	Fatigue 01/2021 - 01/2016
3	Nausea 01/2021 - 01/2016
2	Constipation 10/2023 - 10/2020
2	Diarrhea 01/2021 - 10/2020
2	Vomiting 01/2021 - 01/2016
2	Chondrosarcoma 07/2014 - 11/2012
2	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 04/2011 - 12/2007
1	Primitive Neuroectodermal Tumors (PNET) 01/2023
1	Fibrosarcoma 06/2022
1	Long Term Adverse Effects 06/2022
1	Pathologic Complete Response 03/2021
1	Necrosis 03/2021
1	Margins of Excision 01/2021
1	Edema (Dropsy) 01/2021
1	Anemia 01/2021
1	Hemorrhage 01/2021
1	Oncogene Addiction 01/2021
1	Alopecia (Baldness) 10/2020
1	Myalgia 10/2020
1	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 01/2016
1	Injection Site Reaction 01/2016
1	Spasm (Spasms) 01/2016
1	Abdominal Pain (Pain, Abdominal) 05/2015
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 07/2014
1	Prostatic Neoplasms (Prostate Cancer) 07/2012
1	Genomic Instability 01/2011
1	Dysgeusia (Parageusia) 09/2010
1	Stomatitis 09/2010
1	Body Weight (Weight, Body) 09/2010
1	Mucositis 09/2010
1	Carcinogenesis 03/2009
1	Residual Neoplasm 07/2008
1	Rheumatoid Arthritis 03/2008
1	Keratitis 03/2008
1	Toxic Optic Neuropathy 03/2008
1	Corneal Ulcer 03/2008
1	Cardiotoxicity 12/2007

Drug/Important Bio-Agent (IBA)

13	Imatinib Mesylate (Gleevec)FDA Link 01/2024 - 12/2003
5	ripretinibIBA 01/2024 - 10/2020
5	Biomarkers (Surrogate Marker)IBA 01/2024 - 07/2008
5	Tyrosine Kinase InhibitorsIBA 01/2023 - 01/2005
4	Phosphotransferases (Kinase)IBA 01/2023 - 12/2007
4	Proteins (Proteins, Gene)FDA Link 06/2022 - 04/2010
3	Sunitinib (Sutent)FDA Link 01/2024 - 12/2022
3	Complement System Proteins (Complement)IBA 01/2023 - 02/2007
3	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 10/2021 - 01/2021
3	avapritinibIBA 10/2021 - 01/2021
2	nilotinib FDA Link 05/2015 - 04/2011
2	Messenger RNA (mRNA)IBA 07/2012 - 04/2010
2	ParaffinIBA 05/2010 - 04/2010
2	Formaldehyde (Formol)FDA Link 05/2010 - 04/2010
1	olaratumabIBA 01/2023
1	pazopanib FDA Link 01/2023
1	pembrolizumabIBA 01/2023
1	Immune Checkpoint InhibitorsIBA 01/2023
1	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2023
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2023
1	Vincristine (Oncovin)FDA LinkGeneric 01/2023
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2023
1	tyrosine receptor (receptor, tyrosine)IBA 06/2022
1	larotrectinibIBA 06/2022
1	TropomyosinIBA 06/2022
1	regorafenibIBA 10/2021
1	Tyrosine (L-Tyrosine)FDA Link 01/2021
1	Oncogene Proteins (Oncogene Protein)IBA 10/2020
1	crenigacestatIBA 11/2018
1	(2,4- dihydroxy- 5- isopropylphenyl)- (5- (4- methylpiperazin- 1- ylmethyl)- 1,3- dihydroisoindol- 2- yl)methanoneIBA 01/2016
1	Lipase (Acid Lipase)FDA Link 05/2015
1	Alanine Transaminase (SGPT)IBA 05/2015
1	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 07/2014
1	human TNFSF10 proteinIBA 11/2012
1	TNF-Related Apoptosis-Inducing Ligand ReceptorsIBA 11/2012
1	Untranslated RNA (Noncoding RNA)IBA 07/2012
1	Fibroblast Growth Factor 7 FDA Link 09/2010
1	WW Domain-Containing OxidoreductaseIBA 05/2010
1	exodeoxyribonuclease IIBA 04/2010
1	MidkineIBA 08/2008
1	Anti-Bacterial Agents (Antibiotics)IBA 03/2008
1	perifosineIBA 03/2008
1	SteroidsIBA 03/2008

Therapy/Procedure

16	Therapeutics 01/2023 - 12/2003
8	Drug Therapy (Chemotherapy) 01/2023 - 05/2010
4	Radiotherapy 01/2021 - 12/2005
2	Immunotherapy 01/2023 - 01/2021
2	Aftercare (After-Treatment) 12/2022 - 01/2007
2	Surgical Amputation (Amputations) 06/2022 - 01/2021
2	Neoadjuvant Therapy 03/2021 - 05/2010
2	Precision Medicine 01/2018 - 01/2018
1	Laparotomy 01/2023
1	Metastasectomy 02/2011
1	Hematopoietic Stem Cell Transplantation 09/2010
1	Activities of Daily Living (ADL) 03/2008
1	Slit Lamp 03/2008