Pierre-Louis Tharaux Selected Research

Hypertension (High Blood Pressure)

1/2021	Sunitinib-induced cardiac hypertrophy and the endothelin axis.
1/2021	Calpastatin prevents Angiotensin II-mediated podocyte injury through maintenance of autophagy.
1/2019	A novel role for myeloid endothelin-B receptors in hypertension.
2/2012	Endothelin and the podocyte.
1/2010	A role for angiotensin II type 1 receptors on bone marrow-derived cells in the pathogenesis of angiotensin II-dependent hypertension.
8/2008	Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension.
2/2007	Transglutaminase-dependent RhoA activation and depletion by serotonin in vascular smooth muscle cells.
8/2006	Transforming growth factor-alpha mediates nuclear factor kappaB activation in strained arteries.
5/2004	Prevention of renal vascular and glomerular fibrosis by epidermal growth factor receptor inhibition.
2/2004	Progression and regression in renal vascular and glomerular fibrosis.

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Pierre-Louis Tharaux Research Topics

Disease

13	COVID-19 11/2023 - 01/2020
11	Fibrosis (Cirrhosis) 12/2022 - 01/2002
11	Hypertension (High Blood Pressure) 01/2021 - 02/2003
10	Albuminuria 11/2023 - 01/2010
10	Glomerulonephritis 12/2022 - 09/2011
8	Sickle Cell Anemia (Hemoglobin S Disease) 12/2020 - 11/2005
7	Proteinuria 11/2023 - 02/2012
7	Inflammation (Inflammations) 10/2022 - 01/2016
6	Pneumonia (Pneumonitis) 11/2023 - 01/2021
6	Renal Insufficiency (Renal Failure) 12/2016 - 09/2011
5	Diabetic Nephropathies (Diabetic Nephropathy) 11/2023 - 02/2012
4	Atherosclerosis 01/2023 - 01/2018
4	Disease Progression 01/2023 - 07/2017
4	Kidney Diseases (Kidney Disease) 12/2022 - 08/2008
4	Hypoxia (Hypoxemia) 01/2019 - 11/2005
3	Chronic Renal Insufficiency 10/2022 - 01/2011
3	Chronic Kidney Failure (Chronic Renal Failure) 11/2020 - 02/2004
3	Vasculitis (Vasculitides) 01/2019 - 07/2012
3	Wounds and Injuries (Trauma) 12/2017 - 02/2016
2	Thrombosis (Thrombus) 11/2023 - 11/2019
2	Acute Kidney Injury (Acute Renal Failure) 12/2022 - 10/2022
2	Cardiotoxicity 01/2021 - 01/2017
2	Neoplasms (Cancer) 01/2021 - 01/2018
2	Cicatrix (Scar) 01/2021 - 11/2005
2	Hemorrhage 11/2019 - 09/2006
2	Thrombocytopenia (Thrombopenia) 11/2019 - 09/2014
2	Hyperglycemia 05/2017 - 01/2017
2	Hemolysis 06/2015 - 05/2010
2	Sclerosis 05/2014 - 01/2002
2	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) 07/2012 - 02/2012
2	Renovascular Hypertension (Goldblatt Syndrome) 03/2004 - 01/2004
2	Pathologic Constriction (Stenosis) 03/2004 - 01/2004
1	VEXAS syndrome 01/2024
1	Venous Thrombosis (Deep-Vein Thrombosis) 11/2023
1	Atherosclerotic Plaque (Atheroma) 01/2023
1	Malaria 01/2023
1	Anemia 01/2023
1	Infections 01/2023

Drug/Important Bio-Agent (IBA)

11	Endothelins (Endothelin)IBA 12/2022 - 01/2002
8	Angiotensin IIIBA 01/2021 - 01/2002
7	Proteins (Proteins, Gene)FDA Link 01/2023 - 01/2004
6	CytokinesIBA 01/2024 - 02/2004
6	Oxygen (Dioxygen)IBA 11/2023 - 10/2010
6	ErbB Receptors (EGF Receptor)IBA 06/2018 - 05/2004
5	Endothelin Receptor AntagonistsIBA 01/2021 - 01/2002
5	Hemoglobins (Hemoglobin)IBA 01/2019 - 05/2010
4	Endothelin Receptors (Endothelin Receptor)IBA 01/2017 - 05/2008
4	Endothelin-1 (Endothelin 1)IBA 12/2016 - 11/2005
3	Streptozocin (Streptozotocin)FDA Link 11/2023 - 05/2014
3	tocilizumab (atlizumab)FDA Link 04/2022 - 01/2021
3	AutoantibodiesIBA 01/2022 - 01/2021
3	Interleukin-6 (Interleukin 6)IBA 01/2021 - 01/2018
3	LipidsIBA 11/2019 - 01/2018
3	CollagenIBA 01/2016 - 02/2003
3	ReninIBA 03/2004 - 01/2002
2	EnzymesIBA 01/2024 - 02/2004
2	nephrinIBA 11/2023 - 11/2020
2	TRPC6 Cation ChannelIBA 11/2023 - 05/2017
2	calpastatinIBA 11/2023 - 01/2021
2	CalpainIBA 11/2023 - 01/2021
2	Biomarkers (Surrogate Marker)IBA 01/2023 - 10/2022
2	RNA (Ribonucleic Acid)IBA 01/2023 - 01/2022
2	Transcription Factors (Transcription Factor)IBA 12/2022 - 12/2017
2	Interferon Type IIBA 01/2022 - 01/2020
2	Indicators and Reagents (Reagents)IBA 01/2022 - 01/2016
2	AmphiregulinIBA 01/2022 - 01/2020
2	Fingolimod Hydrochloride (FTY720)FDA Link 01/2021 - 11/2019
2	macitentanIBA 01/2021 - 01/2017
2	Sphingosine-1-Phosphate ReceptorsIBA 01/2021 - 11/2019
2	Sunitinib (Sutent)FDA Link 01/2021 - 01/2017
2	Sirolimus (Rapamycin)FDA Link 11/2020 - 07/2017
2	Phosphotransferases (Kinase)IBA 11/2020 - 01/2017
2	TetraspaninsIBA 10/2020 - 01/2019
2	Endothelin B ReceptorIBA 01/2019 - 01/2017
2	Erlotinib Hydrochloride (CP 358,774)FDA Link 01/2018 - 01/2017
2	TOR Serine-Threonine KinasesIBA 07/2017 - 07/2012
2	AlbuminsIBA 01/2016 - 11/2014
2	antiglomerular basement membrane antibodyIBA 09/2014 - 07/2014
2	Cell Adhesion MoleculesIBA 07/2014 - 05/2014
2	Antigen-Antibody Complex (Immune Complex)IBA 07/2014 - 04/2012
2	Heparin (Liquaemin)FDA LinkGeneric 07/2012 - 04/2012
2	Epidermal Growth Factor (EGF)IBA 07/2012 - 04/2012
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 07/2012 - 04/2012
2	Peptides (Polypeptides)IBA 02/2003 - 01/2002
1	Chemokine ReceptorsIBA 01/2024
1	Interleukin-18 (Interleukin 18)IBA 01/2024
1	InflammasomesIBA 01/2024
1	C-Reactive ProteinIBA 11/2023
1	calpain inhibitorsIBA 11/2023
1	Cysteine Proteases (Cysteine Protease)IBA 11/2023
1	Calcium Channels (Calcium Channel)IBA 11/2023
1	metal transporting protein 1 (ferroportin)IBA 01/2023
1	Messenger RNA (mRNA)IBA 01/2023
1	IronIBA 01/2023
1	InterferonsIBA 01/2023

Therapy/Procedure

5	Therapeutics 11/2023 - 02/2016
2	Artificial Respiration (Mechanical Ventilation) 04/2022 - 01/2022
2	Kidney Transplantation 02/2014 - 02/2004
2	Surgical Instruments (Clip) 03/2004 - 01/2004
1	Nephrectomy 11/2023