Yoshinori Takei Selected Research

Atrioventricular Block

1/2023	Characterization of pathological remodeling in the chronic atrioventricular block cynomolgus monkey heart.
1/2022	Simultaneous analyses of hemodynamic and electrophysiological effects of oseltamivir along with its pharmacokinetic profile using the canine paroxysmal atrial fibrillation model.
8/2021	Corrigendum to: Torsadogenic Action of Cisapride, dl-Sotalol, Bepridil, and Verapamil Analyzed by the Chronic Atrioventricular Block Cynomolgus Monkeys: Comparison With That Reported in the CiPA In Silico Mechanistic Model.
1/2021	Torsadogenic Action of Cisapride, dl-Sotalol, Bepridil, and Verapamil Analyzed by the Chronic Atrioventricular Block Cynomolgus Monkeys: Comparison With That Reported in the CiPA In Silico Mechanistic Model.
1/2021	Analysis of electropharmacological and proarrhythmic effects of donepezil using the halothane-anesthetized intact dogs and the conscious chronic atrioventricular block ones.
8/2020	Risperidone alone did not induce torsade de pointes: Experimental evidence from the chronic atrioventricular block model dogs.
8/2020	In vivo analysis of the effects of intravenously as well as orally administered moxifloxacin on the pharmacokinetic and electrocardiographic variables along with its torsadogenic action in the chronic atrioventricular block cynomolgus monkeys.

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Yoshinori Takei Research Topics

Disease

11	Torsades de Pointes (Torsade de Pointes) 03/2024 - 08/2020
7	Atrioventricular Block 01/2023 - 08/2020
6	Atrial Fibrillation 08/2023 - 01/2021
2	Tachycardia (Tachyarrhythmias) 01/2023 - 03/2021
2	Heart Arrest (Cardiac Arrest) 01/2023 - 03/2021
2	Hypotension (Low Blood Pressure) 01/2023 - 03/2021
2	Heart Failure 11/2022 - 01/2021
2	Alzheimer Disease (Alzheimer's Disease) 04/2022 - 01/2021
2	Inflammation (Inflammations) 01/2019 - 09/2008
2	Glomerulonephritis 01/2015 - 01/2015
2	Neuroblastoma 03/2009 - 03/2008
1	Human Influenza (Influenza) 03/2024
1	Fibrosis (Cirrhosis) 01/2023
1	Orthostatic Hypotension (Postural Hypotension) 01/2023
1	Hyperglycemia 01/2023
1	Mitochondrial Diseases (Mitochondrial Disease) 11/2022
1	Ventricular Fibrillation 06/2022
1	Bradycardia 04/2022
1	Coronary Artery Disease (Coronary Atherosclerosis) 04/2022
1	Myocardial Ischemia (Ischemic Heart Diseases) 04/2022
1	Hypertension (High Blood Pressure) 04/2022
1	Myocardial Infarction 04/2022
1	Neuroinflammatory Diseases 12/2021
1	Bipolar Disorder (Manic Depressive Psychosis) 03/2021
1	Epilepsy (Aura) 03/2021
1	Cardiac Arrhythmias (Arrythmia) 01/2021
1	Kidney Diseases (Kidney Disease) 01/2019
1	Leukemia 01/2019
1	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 01/2019
1	Lymphatic Metastasis 07/2018
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 07/2018
1	Ischemia 01/2018
1	Neoplasms (Cancer) 01/2018
1	Reperfusion Injury 01/2018
1	Acute Kidney Injury (Acute Renal Failure) 01/2018
1	Proteinuria 01/2015

Drug/Important Bio-Agent (IBA)

3	Isoflurane FDA LinkGeneric 03/2024 - 01/2022
3	Sotalol (Sotalol Hydrochloride)FDA LinkGeneric 01/2023 - 01/2021
2	Donepezil (Aricept)FDA LinkGeneric 04/2022 - 01/2021
2	Oseltamivir (Tamiflu)FDA Link 01/2022 - 01/2021
2	Proteins (Proteins, Gene)FDA Link 12/2021 - 01/2019
2	3-(2-carboxyindol-3-yl)propionic acidIBA 08/2021 - 01/2021
2	Cisapride (Propulsid)FDA Link 08/2021 - 01/2021
2	Bepridil (Vascor)FDA Link 08/2021 - 01/2021
2	Verapamil (Calan)FDA LinkGeneric 08/2021 - 01/2021
2	Biomarkers (Surrogate Marker)IBA 01/2019 - 01/2018
2	Transforming Growth Factor beta (TGF-beta)IBA 01/2019 - 01/2018
2	CytokinesIBA 01/2019 - 09/2008
2	activin AIBA 01/2019 - 01/2018
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2008 - 03/2008
2	Nerve Growth Factor (NGF)IBA 09/2008 - 03/2008
1	peramivirIBA 03/2024
1	vernakalantIBA 08/2023
1	Insulin (Novolin)FDA Link 01/2023
1	Angiotensin IIIBA 01/2023
1	Ivermectin (Mectizan)FDA Link 01/2023
1	CatecholaminesIBA 01/2023
1	AldosteroneIBA 01/2023
1	Antiparasitic Agents (Antiparasitics)IBA 01/2023
1	Glucose (Dextrose)FDA LinkGeneric 01/2023
1	Imatinib Mesylate (Gleevec)FDA Link 11/2022
1	Adenosine Triphosphate (ATP)IBA 11/2022
1	AstemizoleIBA 10/2022
1	Haloperidol (Haldol)FDA LinkGeneric 10/2022
1	AVE 0118IBA 08/2022
1	Cholinesterase Inhibitors (Anticholinesterases)IBA 04/2022
1	Memantine (Namenda)FDA Link 04/2022
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 04/2022
1	Antiviral Agents (Antivirals)IBA 01/2022
1	Prostaglandin D2IBA 12/2021
1	Glucagon-Like Peptide 1 (GLP 1)IBA 12/2021
1	ProstaglandinsIBA 12/2021
1	LipidsIBA 12/2021
1	Liraglutide FDA Link 12/2021
1	Ranolazine FDA Link 07/2021
1	Lamotrigine (Lamictal)FDA LinkGeneric 03/2021
1	Dronedarone FDA Link 01/2021
1	poyendaroneIBA 01/2021
1	Halothane (Fluothane)FDA Link 01/2021
1	vanoxerine (I 893)IBA 01/2021
1	AcetylcholinesteraseIBA 01/2021
1	Risperidone (Risperdal Consta)FDA LinkGeneric 08/2020
1	Moxifloxacin (Avelox)FDA Link 08/2020
1	Hemolysin Proteins (Hemolysins)IBA 01/2019
1	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 01/2019
1	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 07/2018
1	Eosine Yellowish-(YS) (Eosin)IBA 07/2018
1	ErbB Receptors (EGF Receptor)IBA 01/2018
1	Cetuximab (Erbitux)FDA Link 01/2018
1	AntibodiesIBA 01/2018
1	AntigensIBA 01/2018
1	PolymersIBA 01/2018
1	IsoenzymesIBA 01/2015
1	Urea (Carbamide)FDA LinkGeneric 01/2015
1	CreatinineIBA 01/2015

Therapy/Procedure

2	Anesthesia 01/2023 - 08/2020
1	Injections 03/2024
1	Heart Massage 06/2022
1	Controlled Hypotension 08/2020
1	Lab-On-A-Chip Devices 01/2018