S Takeda Selected Research

Breast Neoplasms (Breast Cancer)

1/2020	Breast cancer diagnosis based on lipid profiling by probe electrospray ionization mass spectrometry.
9/2015	FOXA1 repression is associated with loss of BRCA1 and increased promoter methylation and chromatin silencing in breast cancer.
1/2015	MicroRNA-574-3p, identified by microRNA library-based functional screening, modulates tamoxifen response in breast cancer.
3/2011	A phase I dose-escalation clinical trial of intraoperative direct intratumoral injection of HF10 oncolytic virus in non-resectable patients with advanced pancreatic cancer.
9/2010	Knockdown of Efp by DNA-modified small interfering RNA inhibits breast cancer cell proliferation and in vivo tumor growth.

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S Takeda Research Topics

Disease

18	Neoplasms (Cancer) 01/2015 - 04/2000
9	Muscular Dystrophies (Muscular Dystrophy) 09/2011 - 02/2000
7	Pancreatic Neoplasms (Pancreatic Cancer) 03/2011 - 03/2001
6	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 01/2016 - 03/2000
6	Infections 10/2013 - 01/2000
6	Body Weight (Weight, Body) 03/2004 - 11/2000
5	Breast Neoplasms (Breast Cancer) 01/2020 - 09/2010
5	Hepatocellular Carcinoma (Hepatoma) 03/2012 - 09/2000
5	Bone Resorption 02/2007 - 04/2000
4	Alzheimer Disease (Alzheimer's Disease) 04/2008 - 01/2000
4	Fibrosis (Cirrhosis) 04/2006 - 04/2000
4	Glomerulonephritis 11/2003 - 04/2001
4	Adenocarcinoma 07/2001 - 01/2000
3	Hyperplasia 01/2014 - 01/2004
3	Hypoxia (Hypoxemia) 06/2012 - 02/2006
3	Osteoporosis 06/2002 - 04/2000
3	Hypertension (High Blood Pressure) 11/2001 - 09/2000
3	Cardiomegaly (Heart Hypertrophy) 01/2001 - 07/2000
2	Congenital Abnormalities (Deformity) 01/2014 - 05/2001
2	Atrial Fibrillation 06/2012 - 06/2001
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 03/2011 - 06/2003
2	Virus Diseases (Viral Diseases) 06/2007 - 12/2000
2	Endolymphatic Hydrops 01/2005 - 02/2000
2	Chromosome Aberrations (Chromosome Abnormalities) 01/2004 - 04/2001
2	Respiratory Insufficiency (Respiratory Failure) 07/2003 - 09/2001
2	Hypotension (Low Blood Pressure) 12/2002 - 06/2000
2	Proteinuria 11/2001 - 09/2000
2	Inflammation (Inflammations) 11/2001 - 02/2000
2	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 09/2000 - 04/2000
1	Diabetes Mellitus 01/2024
1	Frailty 01/2021
1	Dementia (Dementias) 01/2021
1	Experimental Arthritis 01/2018
1	Pneumonia (Pneumonitis) 09/2015
1	Pneumococcal Infections 09/2015
1	Hypersensitivity (Allergy) 08/2015
1	Thrombotic Thrombocytopenic Purpura 07/2013
1	Glioma (Gliomas) 01/2013

Drug/Important Bio-Agent (IBA)

12	Proteins (Proteins, Gene)FDA Link 09/2015 - 01/2000
6	DNA (Deoxyribonucleic Acid)IBA 01/2013 - 04/2008
5	Estrogens (Estrogen)FDA Link 01/2015 - 04/2000
4	DystrophinIBA 09/2011 - 12/2000
4	Messenger RNA (mRNA)IBA 01/2008 - 10/2001
4	Laminin (Merosin)IBA 03/2003 - 02/2000
3	RNA (Ribonucleic Acid)IBA 09/2015 - 09/2000
3	Vitamin D FDA LinkGeneric 02/2007 - 04/2000
3	LeptinIBA 03/2004 - 11/2000
2	Phosphotransferases (Kinase)IBA 01/2024 - 03/2012
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 06/2012 - 04/2008
2	AntigensIBA 04/2012 - 07/2001
2	Small Interfering RNA (siRNA)IBA 09/2010 - 04/2008
2	Triglycerides (Triacylglycerol)IBA 07/2009 - 11/2001
2	Glucose (Dextrose)FDA LinkGeneric 07/2009 - 11/2001
2	Transforming Growth Factor beta (TGF-beta)IBA 05/2008 - 01/2001
2	ElementsIBA 04/2008 - 07/2000
2	eldecalcitol (ED 71)IBA 02/2007 - 04/2002
2	Mitochondrial DNA (mtDNA)IBA 04/2006 - 06/2001
2	Mitomycin (Mitomycin-C)FDA LinkGeneric 01/2004 - 04/2001
2	Antigen-Antibody Complex (Immune Complex)IBA 11/2003 - 11/2001
2	alfacalcidolIBA 04/2002 - 04/2000
2	Presenilin-2IBA 12/2001 - 01/2000
2	Thromboplastin (Tissue Factor)IBA 11/2001 - 02/2000
2	Monoclonal AntibodiesIBA 03/2001 - 11/2000
2	Hormones (Hormone)IBA 01/2001 - 11/2000
1	Biomarkers (Surrogate Marker)IBA 01/2021
1	LipidsIBA 01/2020
1	Interleukin-6 Receptors (Interleukin 6 Receptor)IBA 01/2018
1	Phenobarbital (Luminal)FDA Link 09/2015
1	ChromatinIBA 09/2015
1	VaccinesIBA 09/2015
1	pneumococcal surface protein AIBA 09/2015
1	polyethylene glycol polyethyleneimine nanogelIBA 09/2015
1	PoisonsIBA 08/2015
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 08/2015
1	Type I DNA Topoisomerases (Topoisomerase I)IBA 08/2015
1	olaparibIBA 08/2015
1	CamptothecinIBA 08/2015
1	afimoxifene (hydroxytamoxifen)IBA 01/2015
1	Tamoxifen FDA LinkGeneric 01/2015
1	MicroRNAs (MicroRNA)IBA 01/2015
1	Estrogen ReceptorsIBA 01/2015
1	beta-CrystallinsIBA 01/2014
1	Myosin Light Chains (Myosin Essential Light Chain)IBA 01/2014
1	fibrinogen D fragmentIBA 01/2014
1	Superoxides (Superoxide)IBA 10/2013
1	Antiviral Agents (Antivirals)IBA 09/2013
1	CytokinesIBA 09/2013
1	Immunologic Adjuvants (Immunologic Adjuvant)IBA 09/2013
1	thiamine triphosphorate (TTP)IBA 07/2013
1	Carvedilol (Coreg)FDA LinkGeneric 06/2012

Therapy/Procedure

21	Therapeutics 01/2016 - 01/2000
2	Oncolytic Virotherapy 03/2011 - 03/2007
2	Radiotherapy 06/2008 - 01/2001
2	Ovariectomy (Oophorectomy) 04/2002 - 01/2001
2	Oral Administration 11/2001 - 10/2001
2	Lymph Node Excision (Lymph Node Dissection) 07/2001 - 01/2001
2	Pancreaticoduodenectomy 01/2001 - 01/2001
1	Activities of Daily Living (ADL) 01/2021
1	Transplantation 01/2016
1	Cell Transplantation 01/2016