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Toru Takahashi Selected Research

Fibrosis (Cirrhosis)

9/2013The increase of microRNA-21 during lung fibrosis and its contribution to epithelial-mesenchymal transition in pulmonary epithelial cells.
2/2012Administration of a specific inhibitor of neutrophil elastase attenuates pulmonary fibrosis after acute lung injury in mice.
11/2010Hepatocellular carcinoma, with portal thrombus after viral eradication, disappeared by 5-fluorouracil and interferon.
4/2005Increased pulmonary heme oxygenase-1 and delta-aminolevulinate synthase expression in monocrotaline-induced pulmonary hypertension.
3/2005Comparative study of genotype B and C hepatitis B virus-induced chronic hepatitis in relation to the basic core promoter and precore mutations.
5/2004Tranilast attenuates myocardial fibrosis in association with suppression of monocyte/macrophage infiltration in DOCA/salt hypertensive rats.
5/2003Angiotensin-converting enzyme-gene polymorphism is associated with collagen I synthesis and QT dispersion in essential hypertension.
9/2002Remote development of hepatocellular carcinoma in patients with liver cirrhosis type B serologically cured for HBs antigenemia with long-standing normalization of ALT values.

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Toru Takahashi Research Topics

Disease

19Neoplasms (Cancer)
10/2017 - 01/2003
18Inflammation (Inflammations)
01/2023 - 02/2002
13Wounds and Injuries (Trauma)
07/2010 - 02/2002
12Hemorrhagic Shock
01/2023 - 06/2005
11Infections
01/2021 - 01/2003
11Stomach Neoplasms (Stomach Cancer)
04/2020 - 01/2003
10Lung Injury
01/2023 - 06/2005
10Neoplasm Metastasis (Metastasis)
01/2015 - 11/2002
9Acute Lung Injury
01/2023 - 06/2005
8Fibrosis (Cirrhosis)
09/2013 - 09/2002
7Hepatocellular Carcinoma (Hepatoma)
11/2010 - 09/2002
6Chronic Hepatitis C
02/2017 - 11/2003
6Pneumonia (Pneumonitis)
08/2015 - 03/2005
6Hemorrhage
08/2015 - 06/2007
5Pain (Aches)
05/2023 - 04/2004
5Acute Kidney Injury (Acute Renal Failure)
01/2022 - 02/2002
5Body Weight (Weight, Body)
06/2021 - 01/2008
5Sepsis (Septicemia)
09/2016 - 03/2003
5Chronic Obstructive Pulmonary Disease (COPD)
03/2014 - 05/2011
5Ischemia
02/2012 - 07/2002
4Heart Failure
06/2023 - 02/2004
4Type 2 Diabetes Mellitus (MODY)
10/2020 - 09/2004
4Thrombocytopenia (Thrombopenia)
01/2020 - 05/2008
4Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune)
08/2017 - 05/2006
4Colorectal Neoplasms (Colorectal Cancer)
01/2015 - 11/2002
4Idiopathic Pulmonary Fibrosis
09/2013 - 08/2002
4Insulin Resistance
01/2012 - 09/2004
3Fistula
01/2024 - 06/2010
3Rhinosinusitis
10/2021 - 09/2017
3Endotoxemia
06/2021 - 02/2004
3Pulmonary Edema
05/2019 - 06/2005
3Critical Illness (Critically Ill)
05/2013 - 01/2006
3Reperfusion Injury
02/2012 - 06/2008
3Multiple Myeloma
12/2010 - 02/2005
3Interstitial Lung Diseases (Interstitial Lung Disease)
10/2009 - 08/2002
3Hypoxia (Hypoxemia)
03/2009 - 05/2005
3Thoracic Aortic Aneurysm
11/2007 - 03/2002
2Atrial Fibrillation
01/2024 - 11/2018
2Marfan Syndrome (Marfan's Syndrome)
06/2023 - 01/2004
2Postoperative Pain
05/2023 - 04/2004
2Diarrhea
01/2022 - 10/2005
2Rhabdomyolysis
01/2022 - 01/2017
2Knee Osteoarthritis
11/2021 - 11/2010

Drug/Important Bio-Agent (IBA)

19Heme (Haem)IBA
01/2022 - 07/2002
14Heme Oxygenase-1IBA
01/2017 - 07/2002
11EnzymesIBA
01/2017 - 08/2002
11Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2013 - 03/2003
10Proteins (Proteins, Gene)FDA Link
01/2022 - 02/2002
8Biomarkers (Surrogate Marker)IBA
10/2021 - 04/2006
8Carbon MonoxideIBA
05/2019 - 10/2004
7Messenger RNA (mRNA)IBA
01/2015 - 09/2003
6InterferonsIBA
02/2017 - 11/2003
6Heme Oxygenase (Decyclizing) (Heme Oxygenase)IBA
05/2013 - 02/2002
5Ribavirin (Virazole)FDA LinkGeneric
02/2017 - 11/2008
5DNA (Deoxyribonucleic Acid)IBA
03/2010 - 10/2002
4Immunoglobulin A (IgA)IBA
06/2020 - 01/2017
4LipopolysaccharidesIBA
09/2016 - 03/2003
4SteroidsIBA
02/2015 - 08/2002
4alpha-Fetoproteins (alpha-Fetoprotein)IBA
12/2014 - 01/2004
4Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
01/2013 - 02/2004
4Fluorouracil (Carac)FDA LinkGeneric
11/2010 - 08/2003
4Peroxidase (Myeloperoxidase)IBA
07/2010 - 06/2005
4Cisplatin (Platino)FDA LinkGeneric
09/2007 - 12/2003
4NF-kappa B (NF-kB)IBA
02/2007 - 09/2003
3SolutionsIBA
01/2024 - 05/2005
3Reactive Oxygen Species (Oxygen Radicals)IBA
12/2022 - 01/2005
3MyoglobinIBA
01/2022 - 04/2006
3Transcription Factors (Transcription Factor)IBA
06/2021 - 03/2009
3Therapeutic UsesIBA
05/2019 - 12/2003
3Etoposide (VP 16)FDA LinkGeneric
08/2017 - 12/2003
3Carboplatin (JM8)FDA LinkGeneric
08/2017 - 12/2003
3Prednisolone (Predate)FDA LinkGeneric
09/2015 - 07/2011
3Irinotecan (Camptosar)FDA LinkGeneric
01/2015 - 01/2010
3CytokinesIBA
01/2015 - 02/2004
3InterleukinsIBA
09/2014 - 05/2004
3E-SelectinIBA
03/2014 - 12/2012
3Insulin (Novolin)FDA Link
01/2012 - 09/2002
3Alanine Transaminase (SGPT)IBA
02/2011 - 09/2002
3tin mesoporphyrinIBA
07/2010 - 09/2003
3Caspase 3 (Caspase-3)IBA
01/2009 - 02/2005
3CollagenIBA
09/2007 - 05/2003
35-Aminolevulinate SynthetaseIBA
04/2005 - 01/2003
2Fibrillin-1IBA
06/2023 - 01/2004
2Analgesics (Analgesic Drugs)IBA
05/2023 - 06/2004
2SaltsIBA
12/2022 - 05/2004
2stannous chloride (tin chloride)FDA LinkGeneric
01/2022 - 07/2002

Therapy/Procedure

23Therapeutics
01/2020 - 08/2003
15Drug Therapy (Chemotherapy)
08/2017 - 11/2002
9Resuscitation
01/2023 - 06/2005
5Combination Drug Therapy (Combination Chemotherapy)
01/2015 - 12/2003
4Operative Surgical Procedures
01/2024 - 01/2013
4Critical Care (Surgical Intensive Care)
05/2013 - 12/2004
3Conservative Treatment
11/2018 - 09/2004
3Ligation
11/2010 - 01/2003
3Gastrectomy
01/2010 - 01/2003
2Catheter Ablation
01/2024 - 03/2006
2Catheters
01/2024 - 11/2018
2Autologous Transplantation
01/2024 - 02/2005
2Cesarean Section (Caesarean Section)
06/2023 - 10/2009
2VAP-cyclo protocol
01/2022 - 03/2009