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Sigmar Stricker Selected Research

bis(diazo)benzidine (BDB)

5/2008The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome.
12/2006Cloning and expression pattern of chicken Ror2 and functional characterization of truncating mutations in Brachydactyly type B and Robinow syndrome.
12/2004Modulation of GDF5/BRI-b signalling through interaction with the tyrosine kinase receptor Ror2.

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Sigmar Stricker Research Topics

Disease

4Brachydactyly
11/2012 - 03/2002
4Type B1 Brachydactyly
11/2008 - 12/2004
3Neurofibromatosis 1 (Neurofibromatosis Type I)
12/2020 - 04/2007
3Robinow Syndrome
11/2008 - 12/2006
3Brachydactyly type A2
09/2005 - 10/2003
2Syndactyly (Polysyndactyly)
08/2010 - 03/2002
2Multiple pterygium syndrome
02/2008 - 08/2006
1Fibrosis (Cirrhosis)
12/2017
1Chondrosarcoma
01/2017
1Corneal Injuries
06/2015
1Megalocornea
06/2015
1Type E Brachydactyly
06/2015
1Hypertension (High Blood Pressure)
06/2015
1Stroke (Strokes)
06/2015
1Hypertrophy
11/2013
1Muscular Atrophy (Muscle Atrophy)
11/2013
1Metacarpal 4 5 Fusion
09/2013
1Larsen-Like Syndrome
07/2011
1Joint Dislocations
07/2011
1Scoliosis
07/2011
1Developmental Bone Diseases (Bone Dysplasia)
07/2011
1Zlotogora-Ogur syndrome
08/2010
1Cleft Lip (Harelip)
08/2010
1Ectodermal Dysplasia (Aplasia Cutis Congenita)
08/2010
1HEM dysplasia
07/2010
1X-Linked Mental Retardation (Mental Retardation, X Linked)
02/2010
1Synostosis
11/2009
1Inborn Genetic Diseases (Disease, Hereditary)
05/2008
1Congenital Myasthenic Syndromes (Myasthenia Gravis, Congenital)
02/2008
1type 1 Pena Shokeir syndrome
02/2008
1Arthrogryposis
08/2006
1Neoplasms (Cancer)
07/2006
1Brachydactyly type C
12/2004
1Congenital Abnormalities (Deformity)
10/2004
1type 2 Syndactyly
10/2004
1Polydactyly (Polydactylism)
03/2002

Drug/Important Bio-Agent (IBA)

5Proteins (Proteins, Gene)FDA Link
07/2011 - 10/2004
3Neurofibromin 1 (Neurofibromin)IBA
12/2020 - 04/2007
3LigandsIBA
11/2009 - 12/2004
3Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
11/2008 - 12/2004
3bis(diazo)benzidine (BDB)IBA
05/2008 - 12/2004
2Transcription Factors (Transcription Factor)IBA
12/2017 - 10/2004
2CollagenIBA
12/2017 - 07/2006
2Nonsense Codon (Nonsense Mutation)IBA
09/2013 - 11/2009
2Cholinergic ReceptorsIBA
02/2008 - 08/2006
2Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA
09/2005 - 10/2003
1ChemokinesIBA
12/2017
1Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA
01/2017
1chordinIBA
06/2015
1SaltsIBA
06/2015
1Type 3 Cyclic Nucleotide PhosphodiesterasesIBA
06/2015
1MyostatinIBA
11/2013
1Long Noncoding RNAIBA
11/2012
1ras GTPase-Activating Proteins (ras-GAP)IBA
07/2011
1Proteoglycans (Proteoglycan)IBA
07/2011
1Cell Adhesion MoleculesIBA
08/2010
1NectinsIBA
08/2010
1CholesterolIBA
07/2010
1Oxidoreductases (Dehydrogenase)IBA
07/2010
1SterolsIBA
07/2010
1Histone DemethylasesIBA
02/2010
1AntibodiesIBA
08/2006
1Transforming Growth Factor beta (TGF-beta)IBA
12/2004
1Alanine (L-Alanine)FDA Link
10/2004
1polyalanineIBA
03/2002

Therapy/Procedure

1Therapeutics
06/2015
1Denervation
11/2013