Thomas Spangenberg Selected Research

Praziquantel (Biltricide)

12/2023	Perspective on Schistosomiasis Drug Discovery: Highlights from a Schistosomiasis Drug Discovery Workshop at Wellcome Collection, London, September 2022.
1/2022	Praziquantel Reduces Maternal Mortality and Offspring Morbidity by Enhancing Anti-Helminthic Immune Responses.
12/2021	Mechanism of praziquantel action at a parasitic flatworm ion channel.
1/2021	Praziquantel Treatment of Schistosoma mansoni Infected Mice Renders Them Less Susceptible to Reinfection.
1/2021	Alternatives to Praziquantel for the Prevention and Control of Schistosomiasis.
1/2020	Investigating the antifibrotic effect of the antiparasitic drug Praziquantel in in vitro and in vivo preclinical models.
9/2017	Evaluation of the pharmacokinetic-pharmacodynamic relationship of praziquantel in the Schistosoma mansoni mouse model.
1/2014	Orally active antischistosomal early leads identified from the open access malaria box.

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Thomas Spangenberg Research Topics

Disease

5	Schistosomiasis (Bilharziasis) 05/2024 - 01/2014
5	Malaria 10/2023 - 06/2015
5	Infections 01/2023 - 01/2021
1	Paralysis (Palsy) 12/2021
1	Reinfection 01/2021
1	Fibrosis (Cirrhosis) 01/2020
1	Schistosomiasis haematobia (Schistosomiasis haematobium) 09/2017
1	Acquired Immunodeficiency Syndrome (AIDS) 05/2014
1	Cryptosporidiosis 05/2014
1	Buruli Ulcer 08/2012
1	Myocardial Infarction 12/2010

Drug/Important Bio-Agent (IBA)

8	Praziquantel (Biltricide)FDA Link 12/2023 - 01/2014
2	Antimalarials (Antimalarial Agents)IBA 10/2023 - 06/2015
2	AntigensIBA 01/2022 - 01/2021
2	CytokinesIBA 01/2022 - 01/2021
1	LY 165163 (PAPP)IBA 05/2024
1	Peptide Elongation Factor 2 (EF-2)IBA 10/2023
1	Amino Acids FDA Link 01/2023
1	hemozoinIBA 01/2022
1	pyronaridineIBA 01/2022
1	Immunoglobulin E (IgE)IBA 01/2022
1	CalciumIBA 12/2021
1	Ion Channels (Ion Channel)IBA 12/2021
1	LigandsIBA 12/2021
1	CollagenIBA 01/2021
1	Interleukin-4 (Interleukin 4)IBA 01/2021
1	Chloroquine (Aralen)FDA LinkGeneric 12/2018
1	nitazoxanide (NTZ)FDA Link 05/2014
1	mycolactoneIBA 08/2012
1	Ligases (Synthetase)IBA 12/2010

Therapy/Procedure

2	Therapeutics 05/2024 - 01/2022
2	Mass Drug Administration 12/2023 - 01/2021
1	Chemoprevention 05/2022