Claudio Soto Selected Research

Amyloid Plaque

12/2023	Plasma Exchange Reduces Aβ Levels in Plasma and Decreases Amyloid Plaques in the Brain in a Mouse Model of Alzheimer's Disease.
10/2022	Preventive and therapeutic reduction of amyloid deposition and behavioral impairments in a model of Alzheimer's disease by whole blood exchange.
1/2021	Aged Cattle Brain Displays Alzheimer's Disease-Like Pathology and Promotes Brain Amyloidosis in a Transgenic Animal Model.
1/2021	Identification of Multicolor Fluorescent Probes for Heterogeneous Aβ Deposits in Alzheimer's Disease.
12/2018	Modeling amyloid beta and tau pathology in human cerebral organoids.
10/2016	Reduction of Blood Amyloid-β Oligomers in Alzheimer's Disease Transgenic Mice by c-Abl Kinase Inhibition.
3/2010	Molecular cross talk between misfolded proteins in animal models of Alzheimer's and prion diseases.
1/2005	Amyloid inhibitors and beta-sheet breakers.
4/2003	Pharmacological profiles of peptide drug candidates for the treatment of Alzheimer's disease.
6/2002	Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a beta-sheet breaker peptide.

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Claudio Soto Research Topics

Disease

55	Prion Diseases (Transmissible Spongiform Encephalopathies) 01/2023 - 08/2002
39	Neurodegenerative Diseases (Neurodegenerative Disease) 02/2024 - 08/2002
20	Alzheimer Disease (Alzheimer's Disease) 12/2023 - 06/2002
18	Parkinson Disease (Parkinson's Disease) 02/2024 - 07/2011
12	Infections 10/2023 - 11/2004
12	Scrapie 12/2019 - 09/2002
10	Amyloid Plaque 12/2023 - 06/2002
10	Proteostasis Deficiencies 01/2022 - 01/2006
9	Chronic Wasting Disease 01/2022 - 08/2008
9	Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease) 01/2020 - 10/2003
7	Synucleinopathies 02/2024 - 01/2020
5	Dementia (Dementias) 02/2024 - 06/2008
4	Neuroinflammatory Diseases 01/2022 - 10/2016
4	Bovine Spongiform Encephalopathy (Mad Cow Disease) 01/2021 - 01/2007
4	Multiple System Atrophy 01/2021 - 01/2020
3	Brain Death (Brain Dead) 01/2023 - 12/2018
3	Encephalitis (Encephalitis, Rasmussen) 10/2022 - 01/2011
3	Amyloidosis 01/2021 - 03/2015
3	Disease Progression 01/2019 - 11/2004
3	Type 2 Diabetes Mellitus (MODY) 09/2017 - 07/2011
2	Sporadic Creutzfeldt-Jakob Disease 10/2023 - 12/2016
2	Gliosis 01/2022 - 10/2021
2	Tauopathies 10/2021 - 01/2020
2	Cognitive Dysfunction 01/2021 - 11/2013
2	Communicable Diseases (Infectious Diseases) 12/2019 - 10/2004
2	Inflammation (Inflammations) 10/2019 - 12/2018
2	Hyperglycemia 09/2017 - 05/2017
1	Traumatic Brain Injuries (Traumatic Brain Injury) 07/2023
1	REM Sleep Behavior Disorder 01/2023
1	Anosmia 01/2023
1	Movement Disorders (Movement Disorder) 01/2023
1	Primary Graft Dysfunction 01/2023
1	Body Weight (Weight, Body) 06/2022
1	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 10/2021
1	Frontotemporal Dementia (Semantic Dementia) 10/2021
1	Corticobasal Degeneration 10/2021
1	Memory Disorders (Memory Loss) 01/2021
1	Pure Autonomic Failure 01/2021
1	Atrophy 01/2021
1	Hypoxia (Hypoxemia) 01/2021
1	Hearing Loss (Hearing Impairment) 01/2021
1	COVID-19 01/2021
1	Hemolysis 12/2019
1	Delayed Graft Function 01/2019
1	Overweight 01/2018
1	Glucose Intolerance 09/2017
1	Insulin Resistance 05/2017

Drug/Important Bio-Agent (IBA)

57	PrionsIBA 10/2023 - 08/2002
39	Proteins (Proteins, Gene)FDA Link 01/2023 - 08/2002
32	Prion ProteinsIBA 01/2023 - 09/2002
14	Amyloid (Amyloid Fibrils)IBA 12/2023 - 06/2002
11	SynucleinsIBA 02/2024 - 02/2017
10	Protein AggregatesIBA 12/2023 - 01/2011
9	Amyloid beta-PeptidesIBA 10/2021 - 04/2003
8	alpha-SynucleinIBA 01/2023 - 07/2011
7	Biomarkers (Surrogate Marker)IBA 02/2024 - 01/2019
4	Peptide Hydrolases (Proteases)FDA Link 12/2010 - 11/2004
4	PrPSc ProteinsIBA 12/2010 - 11/2004
3	diazonaphthalenedisulfonic acid (NDS)IBA 02/2024 - 01/2012
3	CalciumIBA 09/2022 - 12/2010
3	tau Proteins (tau Protein)IBA 10/2021 - 01/2020
2	CytokinesIBA 01/2022 - 01/2021
2	Islet Amyloid PolypeptideIBA 09/2017 - 07/2011
2	CalcineurinIBA 04/2011 - 10/2010
2	Protein Isoforms (Isoforms)IBA 06/2009 - 06/2008
2	Peptides (Polypeptides)IBA 04/2003 - 06/2002
1	thioflavin TIBA 12/2023
1	cerebrolysinIBA 07/2023
1	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 01/2023
1	dicarboxydine (DCD)IBA 01/2023
1	Glucose (Dextrose)FDA LinkGeneric 06/2022
1	nobiletinIBA 01/2022
1	InflammasomesIBA 01/2022
1	THK5351IBA 10/2021
1	Fluorescent Dyes (Fluorescent Probes)IBA 01/2021
1	Oxygen (Dioxygen)IBA 01/2021
1	AntibodiesIBA 01/2021
1	Adenosine A2B ReceptorIBA 01/2021
1	Tissue ExtractsIBA 12/2020
1	Dopamine (Intropin)FDA LinkGeneric 01/2020
1	MicroRNAs (MicroRNA)IBA 12/2019
1	Small Untranslated RNAIBA 12/2019
1	Circulating MicroRNAIBA 12/2019
1	HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)IBA 01/2019
1	AluminumIBA 01/2018
1	Stainless Steel (Steel, Stainless)IBA 01/2018
1	PlasticsIBA 01/2018
1	brassIBA 01/2018
1	Glycine (Aminoacetic Acid)FDA LinkGeneric 12/2017
1	Codon (Codons)IBA 12/2017
1	Insulin (Novolin)FDA Link 05/2017

Therapy/Procedure

6	Therapeutics 01/2021 - 11/2009
2	Blood Transfusion (Blood Transfusions) 01/2020 - 12/2008
1	Plasma Exchange 12/2023
1	Heart Transplantation (Grafting, Heart) 01/2023
1	Warm Ischemia 01/2023
1	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2021
1	Immunotherapy 01/2021
1	Heart-Assist Devices 01/2019
1	Endurance Training 01/2018